Sentences with phrase «cytotoxic immune»

One way in which cancer cells flourish is by concealing themselves against cytotoxic immune cells.

«Cytotoxic immune cell in sick and healthy skin a key to understanding vitiligo.»

Not exact matches

The researchers demonstrate that the use of specific cytotoxic substances can also have a beneficial effect on the body's immune system.

Conventional transplant conditioning employs radiation and / or high - dose cytotoxic drugs (also known as alkylators) to destroy the bone marrow and blood and immune cells; it also causes widespread cellular damage throughout the body.

The researchers also analyzed specific immune cells called cytotoxic T cells isolated from the patients» blood and found increases in biomarkers indicative of immune activation.

They are designed to get around one of the ways that cancer protects itself from the immune system: tumors can activate the body's natural protective response from autoimmunity, called a checkpoint, and thereby thwart cytotoxic T cells.

Known as a checkpoint inhibitor, tremelimumab is an investigational monoclonal antibody that «cuts the brakes» of the immune system by targeting cytotoxic T - lymphocyte antigen 4 (CTLA - 4), a protein that can switch off a patient's immune response.

But immune warriors called cytotoxic T cells often attack the virus - infected cells.

They serve to contain viral infections while the adaptive immune response is generating antigen - specific cytotoxic T cells that can clear the infection.

The researchers found that NASH - associated mutations provoke the immune system, including cytotoxic T cells, to recognize and attack the newly emerging cancer cells.

Checkpoint inhibitors are monoclonal antibodies that target certain proteins that downregulate the immune system, such as programmed cell death protein 1 (PD - 1), programmed death - ligand 1 (PD - L1) and cytotoxic T - lymphocyte antigen 4 (CTLA - 4).

Invariant natural killer T (iNKT) cells are rare helper immune cells that activate these cytotoxic cells when cancers go into hiding.

Ipilimumab targets a protein called cytotoxic T lymphocytic antigen - 4 (CTLA - 4) that is found on a type of immune cell called a T cell.

natural killer (NK) cells - a type of cytotoxic lymphocyte that constitute a major component of the innate immune system.

Some of these T cells become «effectos» (the ones that have direct roles in the immune response, including helper functions for CD4 + T cells, and cytotoxic functions for CD8 + T cells), while other T cells differentiate into resting memory cells.

Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a cytokine storm syndrome characterized by immune hyperactivation with viral infection due to a CD8 T cell cytotoxic killing defect secondary to a perforin deficiency.

The researchers demonstrated this by temporarily getting rid of the immune system's cancer - killing cells, called CD8 + or cytotoxic T cells, and showing that without these cells, the virus killed only the initial five percent of cancer cells.

Although we believe our approaches have broad potential across multiple therapeutic areas, we are focused in oncology and have engineered our technologies to activate the immune system's natural ability to create tumor - specific cytotoxic T cells, or CTLs, to fight cancer.

Based on cell surface markers known as CD4 and CD8, T cells generally fall into two broad categories: CD4 — positive helper T cells, which ¬ help activate other immune cells and CD8 - positive cytotoxic T cells, which kill cells that are cancerous or infected with viruses.

«The observed increase in the ratio of cytotoxic CD4 T cells to CD4 helper T cells indicates that they are an important component of the protective immune response to viral infections and that their induction should be an important marker for successful vaccinations against certain viral diseases,» says postdoctoral researcher and first author Veena Patil, Ph.D. «But we really didn't know enough about their molecular profile and the mechanisms that drive their differentiation and maintenance.»

This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).

Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.

Natural killer (NK) cells, the «rapid response» cells of the innate immune system, can kill virally infected cells and thereby slow down an infection until antigen - specific and clonally - expanded cytotoxic T cells can be recruited to finish the job.

ZVex ® and GLAAS ™ are our complementary discovery platforms designed to activate and expand the immune system's natural ability to create tumor - specific cytotoxic T cells (CTLs) in vivo.

Reishi mushroom contains special polysaccharides called beta - glucans said to fight cancer cells by suppressing endothelial growth factor, support the immune system, and enhance cytotoxic receptors (NKG2D / NCR) killer cells.

All the special forces, they radio in the special forces are the cytotoxic or the natural killer kind of that cytotoxic first branch of the immune system, the TH1.

Mice and human volunteers who underwent cycles of the Fasting Mimicking Diet had decreased numbers of myeloid cells, the inflammatory immune cells that become more numerous as we age, and increased numbers of cytotoxic T cells, which protect the body against viruses and cancer.

Autoimmune disorders, which may manifest with granulomas on both the skin and other surfaces, are treated corticosteroids to reduce any inflammation and with chemotherapy, using cytotoxic drugs to suppress the immune system.

Type 1 is IgE mediated; type 2 cytotoxic antibody mediated; type 3 immune - mediated, type 4 cellular mediated.

Worked in a Phase I / II clinical trials research laboratory that focuses on the development of antigen - specific cytotoxic T - lymphocytes for adoptive cellular immune therapies in children and adults