The CNIC research team generated
cytotoxic memory T cells specifically targeting cancer by using different methods for vaccination with tumor antigens.
Not exact matches
Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to
cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector
memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central
memory (TCM) and effector
memory (TEM) subsets.
Some of these T cells become «effectos» (the ones that have direct roles in the immune response, including helper functions for CD4 + T cells, and
cytotoxic functions for CD8 + T cells), while other T cells differentiate into resting
memory cells.