Sentences with phrase «cytotoxicity in»

Magnesium deficiency in vitro enhances free radical - induced intracellular oxidation and cytotoxicity in endothelial cells

The bioconjugate and unmodified QD treatments (the control) were tested for cellular uptake and cytotoxicity in MCF7 (cancerous) and MCF - 10A (comparison) cell cultures.

Tissue inhibitor of metalloproteinase - 1 prevents cytokine - mediated dysfunction and cytotoxicity in pancreatic islets and beta - cells.

A new study demonstrates that it is possible to vaccinate patients with MDS against a decitabine - induced antigen and that the level of induced expression is sufficient to trigger cytotoxicity in patient - derived vaccine - induced T cells.

EOS100850 potently rescues Th1 cytokine production in human whole blood treated by A2A agonists, and increased CD8 + T cell cytotoxicity in a co-culture assay of effector CD8 + T cells and target cancer cells

A secretagogue — small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome.

Suppression of polyglutamine - induced cytotoxicity in Saccharomyces cerevisiae by enhancement of mitochondrial biogenesis.

In their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivo.

Low dietary copper increases fecal free radical production, fecal water alkaline phosphatase activity and cytotoxicity in healthy men.

Not exact matches

Some studies have demonstrated cytotoxicity of silver in wound repair and natural antimicrobials are being sought as alternative topical wound treatments to silver.

Indeed, the toxic compounds in the database, which had been characterized using high - content cytotoxicity screening, showed greater rates of fluorescence quenching.

Sanford and her colleagues wanted to see whether changes in lipid bilayer properties were reliably correlated with a drug's toxicity to cells, or cytotoxicity.

Dsg3 CAAR - T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3 BCRs in vitro and expand, persist, and specifically eliminate Dsg3 - specific B cells in vivo.

The in vitro boosted effector cells were washed once with HBSS and then resuspended in CRPMI and used as effector cells in the cytotoxicity and apoptosis assays (below).

Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III.

We have also have adopted a number of lines of study into the regulation of cytokine production and effector cell responses such, as cytotoxicity, in the response of Vα14 iNKT cells to glycolipid antigens or IL - 12 from activated DCs.

Ortiz C, Morales L, Sastre M, Haskins WE, Matta J. Cytotoxicity and genotoxicity assessment of sandalwood essential oil in human breast cell lines MCF - 7 and MCF - 10A.

The cytotoxicity of niclosamide and oxyclozanide were evaluated against HepG2 human liver carcinoma cells and both drugs caused a dose - dependent loss in cell viability [35,36].

In cytotoxicity assays employing PPAM, we found no significant differences of IC50 values between SCLC tumor cells, SCLC CTC lines which express the Wnt pathway and normal cells such as HEK293 (data not shown).

Cytotoxicity was enhanced by alterations of the regulators of apoptosis, such as Bcl2 / XIAP, in melanoma, lung cancer and adrenocortical carcinoma [9, 19, 21, 67].

Microvesicle - and exosome - mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells.

Rituximab is thought to function through activation of natural killer cells, resulting in cellular cytotoxicity.

This characteristic together with their low cytotoxicity makes them promising candidates for future in vivo evaluation to develop non-peptide CXCR4 inhibitors.

Intracellular retention of the NKG2D ligand MHC class I chain - related gene A in human melanomas confers immune privilege and prevents NK cell - mediated cytotoxicity.

Research Paper In vitro single - strand DNA damage and cancer cell cytotoxicity effects of Temozolomide Shruti Purohit, Devashree Jahagirdar, Azad Kumar, Nilesh Kumar Sharma Oncomedicine 2017; 2: 102 - 110.

tuberculosis and cytotoxicity toward macrophages in a high throughput manner.

Treatment of the Gb3 - expressing gastric carcinoma cell line St3051 with STxB coupled to SN38, the active metabolite of the topoisomerase type I inhibitor irinotecan, resulted in > 100-fold increased cytotoxicity, as compared with irinotecan alone.

Though this exploitation of biochemical and cellular pathways, the Gelipo - TRAIL - Dox combo accumulated more than the controls in the affected tumor tissue and had a greater cytotoxicity.

A failure to repair DNA lesions can result in mutagenesis, large scale genome aberrations and cellular cytotoxicity.

Furthermore, the levels of transcripts of two AlkB genes that protect against the cytotoxicity of methylating agents through repair of the specific DNA lesions generated in single - stranded DNA, Alkhb3 (alkylation repair homolog 3) and Alkhb8 (alkylation repair homolog 8), was lower in the IVC males.

Then, we systematically compared the effect of the hinge domains on the growth kinetics, cytokine production, and cytotoxicity of CAR T cells in vitro and in vivo.

The cytotoxicities of IMGN632 and X-ADC were first assessed in a panel of AML cell lines, which expressed CD123 at levels similar to AML blast cells (ABC values, 1100 - 13000) and encompassed a variety of poor prognostic markers (Table 1).

A Korean study from 2007 acknowledged that vitamin C «is considered a safe and effective therapy» 225 and a 2008 study from the National Institutes of Health found that high - doses of vitamin C displayed «cytotoxicity toward a variety of cancer cells in vitro without adversely affecting normal cells.»

In addition, it demonstrates a significant antihyperglycemic effect and cytotoxicity against prostate cancer.

The systemic effects of stress include increased levels of stress hormones such as cortisol, a decline in certain aspects of immune system function such as natural killer cell cytotoxicity or secretory - IgA levels, and a disruption of gastrointestinal microflora balance.

Selenium helps protect against iodine toxicity by ensuring that glutathione peroxidase activity in the thyroid is adequate to avoid cytotoxicity of hydrogen peroxide (34).

Synaptic Pharmaceutical / Lundbeck Research USA, Paramus • NJ 2002 — 2006 Research Associate Facilitated with assistance in the evaluation and implementation of one new cytotoxicity assay to support compound profiling efforts within projects.

For example, studies of medical students facing examinations and kindergarten children beginning school reveal changes in immune functioning potentially prognostic for adverse health outcomes, including changes in numbers of total t - lymphocytes, natural killer cell cytotoxicity, and lymphocyte responsivity to mitogenic stimulation (e.g., 8, 9).