Replacement of dietary fat by sucrose or starch: effects on 14
d ad libitum energy intake, energy expenditure and body weight in formerly obese and never - obese subjects.
Mice were weaned at 3 weeks, maintained on a 12 - hour light cycle, and
had ad libitum access to water and a standard rodent chow diet (PicoLab Rodent Diet 20, 5053; LabDiet) or a high - fat diet (TD.88137; Harlan Teklad).
Not exact matches
Mice
had access to food (PicoLab Rodent Diet 20; LabDiet) and water
ad libitum.
Rather than throwing ingredients in a blender
ad libitum, measure ingredients beforehand in accordance with what you
'd reasonably eat if you sat down to a solid meal.
Compared to
ad libitum fed controls, rodents maintained on IER (100 % ER / alternate days) for periods of 12 to 24 weeks typically exhibit lower post-treatment levels of fasting glucose 14, 16, 17, 29 and insulin.16, 17, 29 Using this particular IER protocol, Jiang et al28
have also demonstrated an increase in oral glucose tolerance and tissue insulin sensitivity (measured using a hyperinsulinemic - euglycemic clamp) after four weeks in healthy rats.
One study
has tested the efficacy of IER (100 % ER / alternate days) in preventing the development of high - fat diet - induced insulin resistance (IR).54 In this study, rats received
ad libitum access to either standard (control) or high - fat chow.
Furthermore, relatively few studies human studies (Table 1)
have incorporated separate CER (standard treatment) or
ad libitum (no intervention) control groups.
Mean (± SE) spontaneous energy intake decreased by 441 ± 63 kcal /
d, body weight decreased by 4.9 ± 0.5 kg, and fat mass decreased by 3.7 ± 0.4 kg with the
ad libitum, high - protein diet, despite a significantly decreased leptin AUC and increased ghrelin AUC.
Another strength of this study is that all diets were to be consumed
ad libitum - they could eat as much as they wanted, so it more closely reflected what
would happen in real life, outside the setting of a clinical study.
If you allow people to eat «
ad libitum» or all they want till they are comfortably full, from low calorie dense foods, they will lose weight, not be hungry and do not
have to count calories.
Mice under time - restricted feeding
have an equivalent energy intake from a high - fat diet as those with
ad libitum access yet are protected against obesity, hyperinsulinaemia and hepatic steatosis [5, 6].
Protein deficiency is a strong driver of appetite, especially during pregnancy, so it's likely that if the mice
had been allowed to feed
ad libitum there
would have been no problems on a 10 % protein chow.
I
have also done gluten - free back during half of 2011, and I was able to eat
ad libitum (didn't track Calories) and maintain the same weight.
It is concluded that application of the glycemic index in isolation to judge the role of white vegetables in the diet and, specifically in the case of potato as consumed in
ad libitum meals,
has led to premature and possibly counterproductive dietary guidance.»
Numerous subsequent studies
have confirmed that a calorie restriction of 30 to 60 percent of
ad libitum intake increases the life span by similar amounts in a range of organisms including yeast, roundworms and rodents, while simultaneously decreasing or delaying the occurrence of age related diseases such as numerous cancers (including lymphomas, breast and prostate cancers), hypertension, stroke, diabetes, nephropathy, autoimmune disorders and other risks factors for cardiovascular disease (3,4).
If you allow people to eat «
ad libitum» or all they want till the are comfortably full, from low calorie dense foods, they will lose weight, not be hungry and do not
have to count calories.
Scientists
have gone on to put people on low fat high carbohydrate diets (
ad libitum, meaning completely unrestrained intake of carbohydrates), and the results are as good or better than the ADA recommend diet which restricts carbohydrates from entering the bloodstream to begin with.
The results may
have been different on an
ad libitum (eat until fullness) diet.
An
ad libitum, low carb diet
would have that number under 6 in 90 days or less.
Furthermore, even with a really good
ad libitum plan, you
have no choice but to be careful about eating high calorie foods with low satiety.
In obese children, the
ad libitum consumption of a low - GI diet
has been associated with greater reductions in body mass indexes (27).
Assessment of order effects were of interest as they permitted examination of prior sleep history on
ad libitum food intake and energy metabolism (i.e., continuous adequate 9 - h sleep opportunities followed by 5 -
d sleep restriction and 5 -
d sleep restriction followed by 5 -
d, 9 - h adequate / recovery sleep opportunities).
Overall, men expended more energy (2,575.6 ± 64.6 kcal /
d men versus 2,045.2 ± 56.6 kcal /
d women), consumed more calories (3,850.8 ± 118.9 versus 2,277.4 ± 92.4 kcal /
d), were in greater positive energy balance (1,275.2 ± 80.2 versus 232.2 ± 74.2 kcal /
d), and gained more weight (0.95 ± 0.14 versus 0.13 ± 0.16 kg) than women during
ad libitum food availability regardless of sleep opportunity (all sex differences P < 0.0015).
Extreme periods of food abstinence (such as fasting one day and eating
ad libitum the next day) may actually
have the inverse effects.
Adhering to these traditional concepts the US Department of Agriculture
has concluded that diets, which reduce calories, will result in effective weight loss independent of the macronutrient composition, which is considered less important, even irrelevant.14 In contrast with these views, the majority of
ad -
libitum studies demonstrate that subjects who follow a low - carbohydrate diet lose more weight during the first 3 — 6 months compared with those who follow balanced diets.15, 16, 17 One hypothesis is that the use of energy from proteins in VLCKD is an «expensive» process for the body and so can lead to a «waste of calories», and therefore increased weight loss compared with other «less - expensive» diets.13, 18, 19 The average human body requires 60 — 65 g of glucose per day, and during the first phase of a diet very low in carbohydrates this is partially (16 %) obtained from glycerol, with the major part derived via gluconeogenesis from proteins of either dietary or tissue origin.12 The energy cost of gluconeogenesis
has been confirmed in several studies7 and it
has been calculated at ∼ 400 — 600 Kcal / day (due to both endogenous and food source proteins.18 Despite this, there is no direct experimental evidence to support this intriguing hypothesis; on the contrary, a recent study reported that there were no changes in resting energy expenditure after a VLCKD.20 A simpler, perhaps more likely, explanation for improved weight loss is a possible appetite - suppressant action of ketosis.
It is pretty hard to create more than mild signs of HD in a dog with very few bad genes, though, and my litter mentioned earlier which
had been fed
ad libitum is an example.