Sentences with word «dacarbazine»

The MEK inhibitor binimetinib improved progression - free survival compared with dacarbazine in patients with NRAS - mutant melanoma, according to the results of the NEMO trial.

Current treatments for melanoma patients include dacarbazine and temozolomide, which have an unsatisfactory response rate.

After frustrating decades of little progress, the landscape of melanoma therapy was dramatically altered with the first report in 2010 of significantly improved overall survival with the cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) inhibitor ipilimumab, compared with a vaccine, and subsequently, compared with the then «standard» chemotherapeutic agent dacarbazine (DTIC).

The MEK inhibitor binimetinib resulted in improved progression - free survival and response rates vs dacarbazine in patients with NRAS - mutated metastatic melanoma.

Currently immunotherapy is the best treatment, however; before this treatment modality, chemotherapy used to be the treatment of choice for metastatic melanoma and it was based on 2 FDA - approved drugs: fotemustine, dacarbazine [9].

However, more research on this outcome is needed because few patients in this study received dacarbazine.

There was no effect of obesity found among two cohorts (541 patients) treated only with the chemotherapy dacarbazine.

In its dossier, the drug manufacturer used one study of direct comparison that tested eribulin against dacarbazine.

Studies of standard chemotherapy regimens such as dacarbazine and paclitaxel / carboplatin showed response rates for mucosal melanomas that were comparable to those seen in cutaneous melanomas.

Although dacarbazine has been part of the standard of care for metastatic melanoma for more than 30 years, it has never been shown to increase overall survival in this patient population.

The latter was also true for the data from an indirect comparison: Here, the manufacturer analysed studies that compared either eribulin or trabectedin with dacarbazine.

Combination chemotherapy, including dacarbazine, has helped some patients.

The study also suggested that stomach cancer risk was increased for patients who received a similar alkylating agent, dacarbazine, which is commonly used to treat Hodgkin lymphoma today.

In the control arm, dacarbazine was not used in compliance with the approval, however: Instead of administration in combination with another drug (doxorubicin), dacarbazine was used as monotherapy, and a different dosage was used in the beginning of the treatment.

The approval was based on a clinical trial comparing brentuximab vedotin plus conmbination chemotherapy (Adriamycin [doxorubicin], vinblastine and dacarbazine, or AVD) vs a chemotherapy - only regimen commonly used to treat cHL (AVD plus bleomycin, also known as ABVD).

Plerixafor in combination with the chemotherapeutic agent dacarbazine significantly suppressed the metastatic phenotype of melanoma compared to dacarbazine alone [40].

[61,62] Small retrospective studies of biochemotherapy (cisplatin, vinblastine, dacarbazine, interferon alfa - 2b, and IL - 2) also demonstrated activity that was similar in cutaneous and mucosal melanomas.

Dacarbazine - based chemotherapy as first - line treatment in noncutaneous metastatic melanoma: multicenter, retrospective analysis in Asia.

Mature results of a phase III randomized trial of bacillus Calmette - Guerin (BCG) versus observation and BCG plus dacarbazine versus BCG in the adjuvant therapy of American Joint Committee on Cancer stage I - III melanoma (E1673).

A phase 3 clinical trial to evaluate the safety and efficacy of treatment with 2 mg intralesional Allovectin - 7 ® compared to dacarbazine (DTIC) or temozolomide (TMZ) in subjects with recurrent metastatic melanoma.

The study compared the effects of combining ipilimumab with chemotherapy (dacarbazine) versus chemotherapy alone.