Sentences with phrase «dag in»

I note that this estimate is smack dag in the middle of the IPCC's climate sensitivity range of 1.5 - 4.5 degrees Celsius.

We are currently advertising the DAG in, fliers, the new «Toolkit for Dads», the CAFC match programmes, Greenwich «What's On» magazine and Greenwich Time.

Not exact matches

Two weeks after Cheyer and his co-founders, Dag Kittlaus and Tom Gruber, launched Siri as an app in the Apple store in February 2010, Jobs called their office — unannounced.

Samsung moved to play catch up in October by buying Viv Labs, a company started by Siri co-creators Dag Kittlaus and Adam Cheyer.

CareDx had raised over $ 120 million in VC funding from such firms as Kleiner Perkins Caufield & Byers (17 % pre-IPO stake), TPG Biotech (16.5 %), Sprout Group (11.1 %), Intel Capital (10.2 %), Burrill & Co. (9.4 %), DAG Ventures (7.3 %) and Integral Capital Partners (5.6 %).

The company launched in 2008 and has raised approximately $ 160 million from Google Capital, Tiger Global, Benchmark, Battery Ventures, Sutter Hill Ventures, DAG Ventures, Dragoneer Investment Group, and others.

«Our aim is to complete a program that would normally take four years and do it in half the time, while still doing it right,» said Dag Reckhorn, Vice President of Global Manufacturing at Faraday Future.

Dag Hammarskjold was an exception that proves the rule — one of the few model bureaucrats who refused to be ensnared by organizational sharks and imprisoned in official channels.

In an address at Cambridge University on June 5, 1958 Dag Hammarskjold, the Secretary General of the United Nations, echoes Buber's call for renewed «contact and communications across geographical and political boundaries.»

With regard to «holy worldliness», Bishop Paulose quotes from the diary of Dag Hammarskjold, the second Secretary - General of the United Nations, Markings, «In our era, the road to holiness necessarily passes through the world of action».

Dag Hammarskjold Wrote: «In our era, that road to holiness necessarily passes through the world of action.

Dag Hammarskjold writes in this way about our choices,

The activities of the DAG and activities for dads in Children's Centres has been regularly covered in «Greenwich Time», which has carried the message that Children's Centres are a place for dads too.

The book is coauthored with Dag Detter and was included in the Financial Times» and the Economists» best book of the year 2015 list.

Most state - owned companies — such as the oil giant Petrobras in Brazil, state - owned banks in India, and state - owned enterprises in China — are wasteful and corrupt of which I give ample evidence in my book, The Public Wealth of Nations (co-authored with Dag Detter).

Held today in Dag Hammarskjold Plaza, just across from the United Nations, the rally featured many elected officials.

The day began with a rally in an overflowing Dag Hammarskjold Plaza, with thousands more people filling the surrounding streets.

Marching from Dag Hammarskjold Plaza, opposite the Trump World Tower, to Fifth Avenue near Trump Tower, the enormous throng voiced their disagreement with many things Trump; from snarky dismissals of his «small hands», to his stated opposition to abortion and reproductive rights to his misogynsitic views crystallized in his infamous Access Hollywood recording.

As Women's Marches were about to begin in New York and across the country, WAMC's Alan Chartock called in from the staging area at Dag Hammarskjold park.

One of his professors, Dag Jenssen, persuaded Helleday to join his lab in the Department of Genetics, Microbiology, and Toxicology at Stockholm University to investigate the importance of recombination in somatic cells, tumor cells, and cancer initiation.

Dag Hessen, professor at the Department of biosciences at the University of Oslo, is one of the researchers behind two new studies of the condition in Norwegian lakes.

The answers are turning up in traces of mound settlements bordering the rugged Kopet - Dag mountains to the south, which rise up to form the vast Iranian plateau.

Therefore, the new DAG synthesis is much cheaper and safer to produce, thus paving the way for this material to be made in larger scale quantities,» Sabatini said.

Now that a higher - yielding, safer, and scalable process for producing DAG is in place, promising energetic materials made from this intermediate may be explored for their potential explosive applications in an efficient manner.

DAG proceeds in a low chemical yield of 40 percent by this synthesis method, with the remaining 60 percent of the possible product being lost.

In the background, DAG is being synthesized in a pair of 500 gram scaleIn the background, DAG is being synthesized in a pair of 500 gram scalein a pair of 500 gram scales.

Although Erik Axel Karlfeldt won the 1931 Nobel Prize in Literature six months after his death and Dag Hammarskjöld died a month before he was named winner of the 1961 Peace Prize, Steinman is the first posthumous winner since the prohibition began in 1974.

Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).

Given the predominant role for DAG on regulating Ras / Erk and PKC - θ signaling and Cbl - b for regulating PI (3) K signaling, we hypothesized that T cells deficient in DGKζ or Cbl - b would alter TCR signal transduction through distinct mechanisms, such that DGKζ - deficient T cells would demonstrate strongly enhanced Ras / ERK activation, but only modestly enhanced NF - κB activation, and Cbl - b — deficient T cells would demonstrate modestly enhanced Ras / ERK activation and strongly enhanced NF - κB activation.

Deletion of DGKζ from T cells results in prolonged TCR signal transduction downstream of DAG, resulting in enhanced activation of Ras, increased effector T cell proliferation, and amplified cytokine production, which leads to increased antitumor activity against s.c. implanted EL4 tumors or murine mesothelioma (12, 16, 17).

These characterizations were requisite because work by others demonstrated that expression of a constitutively active form of another DGK allele important in regulating DAG levels in T cells, DGKα, resulted in developmental blockade of T cells between progression from DN to DP (40).

Stimulation of the TCR results in cleavage of phosphatidylinositol 4,5 - bisphosphate to form inositol 1,4,5 - trisphosphate, which induces intracellular calcium flux, and DAG, which binds to RasGRP1 and PKC - θ to contribute to activation of these proteins (28).

DGKζ, a lipid kinase, phosphorylates the second messenger DAG, terminating DAG - mediated activation of RasGRP1 and PKC - θ, whereas Cbl - b, an E3 ubiquitin ligase, facilitates ubiquitination and subsequent degradation of the p85 subunit of PI (3) K. Previous studies have evaluated numerous aspects of T cell biology in the two models (16 — 18, 25, 38), but the signaling and functional effects of DKGζ deficiency and Cbl - b deficiency in T cells had not been directly compared.

Here we show how second messengers relevant to the Gq signaling pathway can be detected in living cells using assays for DAG, PIP2, and Ca2 +.

In addition, we prepared a large number of tools to manipulate signalling networks and are able to locally activate the important messenger such as PIP3 and DAG with a light flash in subcellular resolution in living cells (Mentel et al. 2011; Nadler et al. 2013, Nadler et al. submittedIn addition, we prepared a large number of tools to manipulate signalling networks and are able to locally activate the important messenger such as PIP3 and DAG with a light flash in subcellular resolution in living cells (Mentel et al. 2011; Nadler et al. 2013, Nadler et al. submittedin subcellular resolution in living cells (Mentel et al. 2011; Nadler et al. 2013, Nadler et al. submittedin living cells (Mentel et al. 2011; Nadler et al. 2013, Nadler et al. submitted).

In Gq - coupled signaling, DAG and intracellular calcium act as second messengers, ultimately influencing cell functions.

PLC - beta is a 150 kDa enzyme that catalyzes the hydrolysis of phosphoinositide PtdIns (4,5) P2 located in the plasma membrane into diacylglcyerol (DAG) and Ins (1,4,5) P3.

If you consume 10 g creatine twice a dag for a week, the amount of water in your body increases by 400 - 800 g.

This Christian theological daybook, partly inspired by Dag Hammarskjöld's famous journal, periodically shares brief pensees or observations in «a crosswise manner.»

While you play as Tim and there's a ton of great characters in the game, Detective Pikachu stands out, he's genuinely a warming character, makes you laugh, a bit of a dag and a romantic.

The latter, in particular, seems underdeveloped with Dag and his co-writer Ladinigg seeming to throw it into proceedings for the sake of reminding the audience that this is an important film dealing with serious social issues.

While the cows, chickens, pigs and horses whoop it up in the shed, Ben stands as a sentinel, protecting them from an encroaching pack of hungry coyotes led by Dag (voice by David Koechner).

Our drive would take us from here on a meandering north - easterly route to the Kristiansund Airport in Kvernberget, Norway, where we'd catch a plane south to Oslo before bidding «god dag» to Norway for home.

Then in the third person, Gaute Heivoll - or, at least, the Gaute Heivoll who appears in the book - details the families affected by the fires 35 years before, tells us about the fire department, and, especially, lets us enter into the life of the fire chief, Ingemann, his wife, Alma, and their only child, a son named Dag.

Dag, in many ways, resembles the Gaute Heivoll we meet in the book: a talented student and an overachiever intent on success.

In writing the narrative of Dag, Heivoll is writing some of his own story, especially when he is describing both his and Dag's relationships with their fathers, which, ironically, are the opposite of what the reader may expect.

Take note though that due to fluctuation in pricing from daily resets of leveraged ETFs and ETNs, DAG is up only 9 % on the year.

This Christian theological daybook, partly inspired by Dag Hammarskjöld's famous journal, periodically shares brief pensees or observations in «a crosswise manner.»

As it says in the trailer itself, Dreamfall Chapters is certainly one of our most anticipated games of this year, and if you want to learn more about it you can check out my interview with developers Dag Scheve and Ragnar Tørnquist here, but stay tuned to the site as we'll be keeping a close eye on Red Thread Games» upcoming title in the coming months.

Being the people that brought fan favourite character Crow to life in The Longest Journey and its sequel Dreamfall, it's safe to say that Dag Scheve & Ragnar Tørnquist of Red Thread Games know a thing or two about charming and majestic animals.