Sentences with phrase «damage accumulation in»

A pivotal factor in the shift from damage repair to damage accumulation in the aging adult is that during the night and early morning hours, older individuals are producing less glutathione (GSH).

They used molecular dynamics simulations to compare radiation damage accumulation in two ceramics and determined three requirements for the ideal radiation - tolerant ceramic:

Not exact matches

One study published in the American Academy of Optometry's Optometry & Vision Science journal found that using goji berry daily as a dietary supplementation for 90 days increases plasma zeaxanthin and antioxidant levels significantly, which protect eyes from hypopigmentation and accumulation of oxidative stress compounds that can damage the macula.

In this study, partial reprogramming of cells in vitro reduced DNA damage accumulation and restored nuclear structurIn this study, partial reprogramming of cells in vitro reduced DNA damage accumulation and restored nuclear structurin vitro reduced DNA damage accumulation and restored nuclear structure.

The newly identified gene affects accumulation of amyloid - beta, a protein believed to be one of the main causes of the damage that underpins this brain disease in humans.

Scientists have associated the accumulation of these clusters with tissue damage that leaves sponge - like holes in the brain.

The finding identifies how vulnerable cell groups react and respond differently to the accumulation of mitochondrial DNA damage seen in the disease, highlighting the need for cell - specific treatments.

The accumulation of these clusters has been associated with tissue damage that leaves sponge - like holes in the brain.

In aging, this gene expression presumably occurs to compensate for the accumulation of protein damages; during diapause, the same genes may be activated to prepare the whole embryo to catch up with the interrupted development and be ready to hatch as the rainy season starts.

Results show that one night of partial sleep deprivation activates gene expression patterns in peripheral blood mononuclear cells (PBMCs) consistent with increasing accumulation of damage that initiates cell cycle arrest and increases susceptibility to senescence.

To understand how this accumulation occurs in response to DNA damage, the scientists considered the role of CDK, or cyclin - dependent kinases.

There is a great post at the Council on Foreign Relations blog where by Michael Levi boils down global climate change in to two overarching unknowns: (1) extent of damage by an accumulation of greenhouse gases, and (2) an uncertainty around which policies, or set of policies, will succeed in reducing emissions.

Fatty liver disease results from excess accumulation of fat in the liver (hepatic steatosis), leading to inflammation and damage to the liver.

In addition, mice treated with hesperidin and eriodictyol had reduced fat accumulation and damage in the liveIn addition, mice treated with hesperidin and eriodictyol had reduced fat accumulation and damage in the livein the liver.

The cause of β cell damage in T2D is currently unknown, but compelling evidence implicates the formation and accumulation of IAPP misfolded aggregates in the pancreas (Hull et al., 2004; Haataja et al., 2008; Jurgens et al., 2011; Mukherjee et al., 2015), in a manner similar to the way protein aggregates have been shown to be causative agents in a variety of chronic and progressive PMDs (Soto, 2003).

On the other hand, if the stressful conditions prevail, accumulation of the damaged symbiotic zooxanthellae may not maintain the expulsion, which will gradually accumulate in coral tissues.

But in obesity, accumulation of lipids can cause fatty liver, resulting in cellular damage to the organ.

These researchers consider that this loss of zooxanthellae and the accumulation of damaged cells results in coral bleaching.

Other genetic diseases include Tay - Sachs disease (damage to the gene for the enzyme hexosaminidase A leads to an accumulation of a chemical in the brain that destroys it), sickle cell anemia (improper coding of the gene that produces hemoglobin), hemophilia (lack of a gene for a blood - clotting factor) and muscular dystrophy (caused by a defective gene on the X chromosome).

Barbara, maybe there'd be too much accumulation (which would have caused too much damage) in an old body for the treatment to be maximally effective?

The latter triggers a vicious cycle of persistent DDR and pro-inflammatory signals leading to chronic inflammation, tissue malfunction and degeneration with old age; in DNA repair - deficient patients, the rapid accumulation of DNA damage (in view of the DNA repair defect) would trigger the untimely activation of DDR signaling leading to the early manifestation of age - related pathology that is associated with chronic inflammation.

Despite the efficiency of DNA repair mechanisms, some DNA damage is left unrepaired leading to the gradual accumulation of DNA lesions in cells.

In addition, the loss of Ripk2 has been demonstrated to result in the inability of cells to carry out mitophagy, leading to enhanced mitochondrial production of superoxide / reactive oxygen species and accumulation of damaged mitochondria that will trigger a caspase 1 — dependent inflammasome activation (Lupfer et al., 2014In addition, the loss of Ripk2 has been demonstrated to result in the inability of cells to carry out mitophagy, leading to enhanced mitochondrial production of superoxide / reactive oxygen species and accumulation of damaged mitochondria that will trigger a caspase 1 — dependent inflammasome activation (Lupfer et al., 2014in the inability of cells to carry out mitophagy, leading to enhanced mitochondrial production of superoxide / reactive oxygen species and accumulation of damaged mitochondria that will trigger a caspase 1 — dependent inflammasome activation (Lupfer et al., 2014).

Age - induced accumulation of nuclear DNA damage, decline in mitochondrial function and alterations in gene expression have been thought to contribute to aging.

The molecular factors that contribute to the age - dependent increase in damage accumulation are still incompletely understood.

One reason for this decline is thought to be the inevitable accumulation of misfolded and damaged proteins with time accompanied by the collapse in the cells» protective protein quality control mechanisms to deal with damaged proteins and restore homeostasis.

«In dermatology, the appearance of hyperpigmented spots — especially in chronic sun - damaged skin — is linked to a high lifetime accumulation of sunlight,» study author Christoph Schwab, MD, wrote in an email to HealtIn dermatology, the appearance of hyperpigmented spots — especially in chronic sun - damaged skin — is linked to a high lifetime accumulation of sunlight,» study author Christoph Schwab, MD, wrote in an email to Healtin chronic sun - damaged skin — is linked to a high lifetime accumulation of sunlight,» study author Christoph Schwab, MD, wrote in an email to Healtin an email to Health.

Many of the studies which demonstrate the effectiveness of ice baths in reducing inflammation and accumulation of white blood cells (the guys responsible for destroying damaged tissue and creating signals for re-growth) measure this response over a very short time frame - for hours or a couple of days at best.

A diet high in saturated and trans fats and low in antioxidants can damage blood vessel walls to cause an immune response related to inflammation and the development of cardiovascular ailments.8, 9,10 Low - grade inflammation in older individuals has been shown to contribute to fat accumulation, insulin resistance, and inflammatory - related diseases.11

In our pharmacological class, we discovered aging due to oxidative damage, number of cell divisons, waste accumulation theory, teleomer lengths, effects due to circadian clock etc..

It is thought that these agents may help to prevent the accumulation of intracellular sorbitol that leads to cellular damage in diabetics.

Research has shown that oxidative damage contributes to many diseases including cancer, heart disease, Alzheimer, and most chronic diseases, and accumulation of oxidative damage plays an important role in the aging process.

Using compression will help prevent fluid accumulation in damaged knee tissues.

For example, the accumulation of LDL cholesterol in the coronary arteries is a result of damage from lipid peroxidation.

It prevents depletion of glutathione, and by that toxic accumulation in the liver that can lead to its permanent damage.

This study found that high dose vitamin B12 shots were linked to greater accumulation of methylmercury in the brain and hence damage.

damaging in the long term and cause fat accumulation, osteoporosis, skin aging, and brain cell damage

Through a complex chain of events, this damage can then cause a release and accumulation of glutamate, which in high concentration is extremely destructive to the body.»

According to the American Heart Association, an elevation in blood pressure can cause damage to the arterial walls, increase the accumulation of plaque, and block blood flow.

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In this context, the term «primary» is used to denote that the condition is direct consequence of the accumulation of copper in the liver tissues and is a direct result of the presence of the inherited «copper accumulation» genes, i.e. it is not the consequence of a malfunction caused by another factor such as damage to the gall bladder which would impair the removal of bile and therefore coppeIn this context, the term «primary» is used to denote that the condition is direct consequence of the accumulation of copper in the liver tissues and is a direct result of the presence of the inherited «copper accumulation» genes, i.e. it is not the consequence of a malfunction caused by another factor such as damage to the gall bladder which would impair the removal of bile and therefore coppein the liver tissues and is a direct result of the presence of the inherited «copper accumulation» genes, i.e. it is not the consequence of a malfunction caused by another factor such as damage to the gall bladder which would impair the removal of bile and therefore copper.

Scraping moving teeth with metal is more likely to damage tooth enamel and lead to more rapid tartar accumulation in the future.

(2) To limit further liver damage by preventing accumulation of copper and free radicals (3) To support liver cell regeneration (4) To prevent or minimize possible complications, such as abnormal brain function caused by passage of toxic substances from the liver to the blood (called hepatic encephalopathy) and the buildup of fluid in your dog's abdomen (called ascites).

Aging in most animals is accompanied by the progressive accumulation of oxidative (or free radical) damage to body tissue, including brain tissue.

In many cases it is impossible to show a direct connection between the damage and a vaccine, since it is the accumulation of many antigens over many years that results in clinically evident disease.&raquIn many cases it is impossible to show a direct connection between the damage and a vaccine, since it is the accumulation of many antigens over many years that results in clinically evident disease.&raquin clinically evident disease.»

In many cases it is impossible to show a direct connection between damage and a vaccine, since it is the accumulation of many antigens over many years that results in clinically evident disease.&raquIn many cases it is impossible to show a direct connection between damage and a vaccine, since it is the accumulation of many antigens over many years that results in clinically evident disease.&raquin clinically evident disease.»

Cats with chronic kidney disease are at risk of developing high blood pressure and this can have a number of damaging effects including acute blindness / blood accumulation in eyes, strain on heart muscle, and worsening of the kidney disease.

A surprising number of cats have problems with constipation (abnormal accumulation of feces and difficulty defecating), and similar but more serious conditions such as obstipation (complete obstruction of the colon by feces) and megacolon (damaged nerves and muscles in the colon causing an inability to defecate).

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In order to combat the unavoidable accumulation of damage, players are provided with a pitstop nestled by the side of the track.