The tiny fish can regrow fins and even repair
damaged heart tissue with genes called fibroblast growth factors and neuregulin 1, respectively.
Not exact matches
Of those who survive, half are left
with brain
damage, which occurs when the
heart starts beating again and a sudden rush of blood into oxygen - starved
tissues triggers an avalanche of treacherous biochemical reactions.
«Diseased,
damaged hearts with a lot of scar
tissue don't contract and relax at the same time throughout the atrium because it is more difficult to rhythmically contract the thicker, tougher
damaged tissue.»
The goal of stem cell therapy is to replace the
damaged tissue with new
heart cells and restore the failing
heart to normal function.
Now,
with new kinds of technologies that are coming up, new types of
tissue engineering and, you know, some of the hopes that people have for stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing
with really badly
damaged hearts that would involve growing a new
heart or replacing or repairing the
damage d to a badly
damaged heart that might make artificial
hearts less important in the somewhat more distant future.
In the United States, about 720,000 residents experience a
heart attack annually, which means that hundreds of thousands of
heart patients are living
with the disabling complications of
heart disease who could benefit from therapies to repair and regenerate
damaged heart tissue.
In the Rutgers study, Zong and lead author Ji - An Pan, a scientist in his laboratory, looked at liver and
heart damage in laboratory mice and found that the mice in which the TRIM21 gene was inactivated suffered little
heart or liver
damage when put through the same laboratory procedures used to produce
tissue damage in mice
with the gene.
If the infection isn't stopped, it can progress into rheumatic fever — a highly contagious disease that affects more than 400,000 people worldwide each year and leaves survivors
with lasting
damage to
heart valves and other
tissue.
Yin noted that
with a better understanding of the genetic underpinnings that lead to
tissue regeneration, he and his team may be able to develop new drug candidates that control the activity of the genetic circuits and repair
damaged hearts.
Because humans have a limited capacity for
heart tissue regeneration,
damaged heart muscle is normally replaced
with a nonfunctional scar.
Friedreich's ataxiais an inherited disease that causes progressive
damage to the nervous system, resulting in symptoms ranging from gait disturbance to speech problems; it can also lead to
heart disease and diabetes.The ataxia of Friedreich's ataxia results from the degeneration of nerve
tissue in the spinal cord, in particular sensory neurons essential (through connections
with the cerebellum) for directing muscle movement of the arms and legs.
But
heart cells never truly regenerate in the
damaged tissue, and myofibroblasts compensate for their absence by forming a stiff, collagenous scar that interferes
with the
heart's ability to maintain stable
heart rhythms and to expand and contract forcefully to pump blood.
«Our hope is to one day treat diseases like
heart failure or Parkinson's disease
with drugs that help the
heart and brain regenerate
damaged areas from their own existing
tissue cells.»
While the scar limits further
tissue damage in the short term, over time its stiffness interferes
with the
heart's ability to pump, leading to disability and ultimately to terminal
heart failure.
High Fructose Corn Syrup (HFCS): Loaded
with «unbound» fructose and glucose molecules, studies have shown that the reactive carbonyl molecules can cause
tissue damage that may lead to obesity, diabetes, and also
heart disease.