Sentences with phrase «damage repair pathways»

This novel vaccine encodes the tumor antigen TERT, which is highly expressed in tumor cells, and is particularly high in tumor samples from patients with mutations in DNA damage repair pathways, such as the BRCA1 / BRCA2 pathway.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

Not exact matches

A major challenge in repairing the brain is obtaining cortical neurons from the appropriate layer and area in order to restore the damaged cortical pathways in a specific manner.

This was because the cells were unable to activate a pathway called homologous recombination that repairs this type of DNA damage.

Without BRCA - induced DNA repair, a molecule called ATM kinase sensed the excessive DNA breaks and activated a chemical pathway that kills off damaged cells.

Such plasticity in what is a major pathway in the adult canary's brain is surprising, say the researchers, and suggests that one day we may find ways of encouraging damaged human brains to repair themselves (Science, vol 249, p 1444).

This migration may happen because the repair pathways initiated by the damaged cells are similar to pathways triggered during embryonic development, where stem cells are key, explains ReNeuron co-founder and chief scientific officer John Sinden.

XPD encodes one of the two helicase components of basal transcription / DNA repair factor IIH (TFIIH), a ten - subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].

In the Medalist + C group, there were alterations in the DNA damage checkpoint pathway machinery that monitors the DNA repair process of the body's cells.

Huda N, Tanaka H, Mendonca MS, Gilley D. DNA damage - induced phosphorylation of TRF2 is required for the fast pathway of DNA double - strand break repair.

For patients with spinal cord injuries, chemical reprogramming promises to repair their damaged neural pathways.

Abstract: In response to DNA lesions, human cells activate checkpoint pathways to repair DNA damage and prevent proliferation of genetically unstable cells.

β - catenin, a transcription factor, has been known to crosstalk with several developmental pathways [28] and is reported to play a role in DNA damage repair [29, 30].

The damage that it will repair is the one that is causal in senenscence of DNA pathway (such x-ray radiation causing senescence) and oncogenic activated senescence; but not of the type of replicative senescence (that's the domain of telomeres / telomerase / sub-telomeres and epigenetics) and cellular replication / proliferation.

(ii) In addition, we have uncovered the first link between pathways that signal DNA damage and mediate DNA - repair and hypoxia - induced neovascularisation in the course of proliferative retinopathies.

DNA repair pathways are constantly active in the cell to identify and correct all DNA damage that may occur.

For instance, classical and alternative pathways interplay and compete for the repair of DSBs occurring during replication (i.e. damaged replication forks)(Figure 1B).

Tsodikov studied a human DNA repair pathway, nucleotide excision repair, focusing on enzymes that cleave damaged DNA.

Such diseases are believed to be initiated by mutations and rearrangements of the DNA sequence.DNA damage generated by ionising radiation, simple alkylating agents or endogenously hydrolytic and oxidative processes is corrected by the base excision repair (BER) pathway.

Specifically, the research demonstrates that grape seed not only damages cancer cells» DNA (by means of an increase of reactive oxygen species), but also prevents the pathways which allow repair (as seen by reduced amounts of the DNA repair molecules Rad51 and Brca1 as well as DNA repair foci).

The innate acids in the extract suppress inflammatory pathways and repair damaged tissue.

This project works to repair the damage wrought by mass incarceration by building pathways from corrections to college, career entry, and family security.