Sentences with phrase «damage response»

"Damage response" refers to the actions or processes that take place when there is harm or injury to something. It is the way in which a system, organism, or entity reacts and tries to repair or overcome the damage. Full definition
On the other hand, inhibition of the DNA damage response in these daughter cells prevents their death.
The team next looked at whether classic damage response signals were activated in the knee joint after injury.
The vaccine will also be useless if your body doesn't produce enough of a response or too damaging a response due to high levels of viral exposure and poor immune coordination.
After 10 days of smoke exposure, the scientists found an overall increase in DNA damage responses to so - called reactive oxygen species within the cells.
They used exome sequencing and immunostaining of DNA damage response proteins in order to evaluate HRR, and findings were then validated in a cohort of breast cancer patients with BRCA1 / 2 mutations who were treated with PARP inhibitors.
They found that inhibition of one component of DNA damage response machinery, a protein called DNAPK - kinase, increased the occurrence of translocations almost 10-fold.
Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.
Sierra Oncology, Inc., a clinical stage drug development company focused on advancing next - generation DNA damage response therapeutics for the treatment of patients with cancer, went public near $ 29 in July 2015, then began a downtrend that continued through a June 2017 all - time low of $ 1.10.
LA JOLLA, CA — Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells.
The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.
We are studying aspects of centromere chromatin dynamics and particularly a cellular response to centromere chromatin damage, called interphase Centromere Damage Response (iCDR).
Ataxia telangiectasia (AT) is caused by a mutation in ATM, a key damage response gene.
Our work identified that these sarcomas lack most of the normal damage responses because of an RNA metabolism issue that traps the BRCA1 protein, the gene usually associated with breast cancer.
Stephen Elledge pioneered the discovery and characterization of the molecular mechanisms of the DNA - damage response pathway
To explore the role of DNA repair in translocation formation, the researchers inhibited key components of the DNA damage response machinery within cells and monitored the effects on the repair of DNA breaks and translocation formation.
Upon DNA damage, ATM induces Ria1 to release its constraints on p53 mRNA, enabling the translocation and translation of the DNA damage response protein transcript.
Less p53 decreases the DNA damage response in patients with Li - Fraumeni Syndrome, and Schiffman's team wondered if more p53 could protect against cancer in elephants by heightening the response to damage.
This group determined that the cause was that the function of the Tel1 protein, which is important for DNA damage response, was not fully implemented in xrs2 mutations.
NYC Mayor Bill de Blasio and Gov. Andrew Cuomo, facing criticism that their political infighting could damage their response to the Legionnaires» outbreak in the Bronx, agreed to craft joint regulations for responding to the disease that has killed 12 and infected more than 100.
Mayor Bill de Blasio and Gov. Andrew Cuomo, facing criticism that their political infighting could damage their response to the Legionnaires» outbreak in the Bronx, agreed Tuesday to craft joint regulations for responding to the disease that has killed 12 and infected more than 100.
«Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,» he said.
A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be incited, which, when repaired incorrectly, will lead to the tumor formation.
The results, published in tomorrow's issue of Cell, might also lead to new measures for preventing gray hair by modulating the DNA damage response.
This work was initially funded by Heidelberg University's FRONTIER programme and eventually by the Collaborative Research Centre «Cellular Surveillance and Damage Response» (SFB 1036).
«The DNA damage response is linked to aging as well.
Among the most interesting ones identified were those associated with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding, calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.
The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators.
The Andres lab research interests are to understand the fundamental molecular mechanisms behind bacterial DNA damage response and repair pathways that contribute to microbial survival.
But no matter how many different ways they did their experiments, the Salk researchers found that TGF - β can interfere with cells» damage responses in premalignant or cancer cells.
Furthermore, niclosamide was found to activate the DNA damage response (DDR)[80].
Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent damage.
Recent evidence points to reciprocal interactions between DNA repair, DNA damage responses and aspects of immunity; both self - maintenance and defense responses share a battery of common players and signaling pathways aimed at safeguarding our bodily functions over time.
This inherent complexity arising from manifold levels of organization within multicellular life forms requires that genome maintenance, the DNA damage response (DDR) and defense strategies are tightly linked and highly coordinated processes.
Since then, she has identified a protein complex at telomeres, which she named shelterin, and demonstrated its role in suppressing DNA damage response and regulating telomere stability.
2008: Molecular Radiation Sciences research accelerated under the leadership of Marikki Laiho, M.D., Ph.D., who began to decipher the biology of DNA - damage response to radiation therapy and how cells sense and repair this damage.
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