Huntington's disease is a genetic disorder that affects around 1 in every 10,000 people and
damages nerve cells in the brain.
Do these antibodies simply function like drugs in the brain or do they «attack» and
damage nerve cells in some ways?»
Not exact matches
His research shows that
in cases of hearing loss, the ear's
nerve fibers become
damaged before the hair
cells do, and when those synaptic fibers reconnect to the hair
cells, it's possible to regain hearing.
This
damages some of the
nerve cells in the brain, and affects my dad's memory, decision - making and personality.
[Robert Siman et al, Serum SNTF Increases
in Concussed Professional Ice Hockey Players and Relates to the Severity of Post Concussion Symptoms] A strong blow to the head causes chemical changes within
nerve cells that
damage their structural proteins.
The study, published Feb. 5
in Nature Neuroscience, showed that the patients»
nerve cells — converted directly from patients» skin
cells — exhibited «symptoms» of the disorder, including DNA
damage, dysfunctional mitochondria and
cell death.
In the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in mic
In the new study, Zigmond and colleagues found
damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites
in mic
in mice.
Levels of a
nerve cell signaling molecule called substance P — measured
in tear samples — might be a useful marker of diabetes - related
nerve damage (neuropathy), suggests a study
in the July issue of Optometry and Vision Science, the official journal of the American Academy of Optometry.
In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirel
In a study published
in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirel
in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune
cells — neutrophils — can clean up
nerve debris, while previous models have attributed
nerve cell damage control to other
cells entirely.
They also found AXIN2
in the
damaged nerve cells of adults with multiple sclerosis, a disease
in which the immune system attacks myelin.
But their prominence at sites where
nerve cells are
damaged by the disease means they deserve careful scrutiny
in the desperate search for ways to arrest the most salient cause of dementia.
Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression
in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of
nerve cells, which protected them from free radicals and structural
damage.
A newly characterized group of pharmacological compounds block both the inflammation and
nerve cell damage seen
in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week
in the journal Nature Neuroscience.
«The compounds identified
in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the
nerve cell damage seen
in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.
These
damaged cells fail to carry glucose into
cells; instead glucose builds up
in the blood and can
damage nerves, blood vessels and organs unless insulin is administered.
Studies
in rats and dogs have already demonstrated that olfactory ensheathing
cells (OECs), which insulate bundles of
nerve cells, can help repair
damage to the spinal cord and
nerves leading to animals» paws.
Others include transplanting so - called Schwann
cells from peripheral
nerves, using growth factors to stimulate
nerve growth, and boosting the immune system
in the
damaged area (New Scientist magazine, 14 August 1999, p 36).
«Our data clearly showed that one of the protein receptors on white blood
cells called CXCR3 brings white blood
cells to the optic
nerve in response to production of its binding partner CXCL10 by
damaged nerve tissue,» said Zhang.
Lou Gehrig's disease, also known as amyotrophic lateral sclerosis, or ALS, might
damage muscle - controlling
nerve cells in the brain earlier
in the disease process than previously known, according to research from the Cedars - Sinai Board of Governors Regenerative Medicine Institute.
Other scientists have shown that tamoxifen and similar drugs might also reduce
nerve cell damage in the spinal cord and brain.
Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates
nerve cell growth
in the
damaged nervous system.
Based on previous studies, researchers have hypothesized that recreational noise exposure might
damage the circuitry between sensory hair
cells in the inner ear and their auditory
nerve targets that deliver information to the brain.
In a study led by Duke Health and published in the journal Alcoholism: Clinical and Experimental Research, scientists demonstrate in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young brai
In a study led by Duke Health and published
in the journal Alcoholism: Clinical and Experimental Research, scientists demonstrate in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young brai
in the journal Alcoholism: Clinical and Experimental Research, scientists demonstrate
in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young brai
in rats that a short duration of the drug donepezil can reverse both structural and genetic
damage that bouts of alcohol use causes
in neurons, or nerve cells, in the young brai
in neurons, or
nerve cells,
in the young brai
in the young brain.
Since Lipton's group co-discovered the SNO reaction some 20 years ago, scientists have linked the reaction to protein misfolding and
nerve cell damage in cases of Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS / Lou Gehrig's disease) and Parkinson's disease, as well as heart / cardiovascular disease and cancer.
By reinsulating
damaged nerves and regenerating
nerve cells, Schwann
cell transplants have earned their stripes
in paralyzed mouse, pig and primate studies over the past decade.
One such treatment is already under development for testing
in humans after the current study showed it stopped
nerve cell damage in mice with ALS.
But if the HLA - A2 gene turns out to be the culprit, then the immune system is probably involved somehow
in Alzheimer's symptoms, says Payami, perhaps by
damaging nerve cells.
RIPK1, the researchers found, inflicts
damage by directly attacking the body's myelin production plants —
nerve cells known as oligodendrocytes, which secrete the soft substance, rich
in fat and protein that wraps around axons to support their function and shield them from
damage.
According to the researchers, how
nerve cells are
damaged in these diseases has remained a mystery until now.
«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause
damage to the eye, and then we also quantified the amount of
nerve cell death
in the back of the eye that mediates the optic neuropathy, and, lastly, we looked at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School.
As a result, mucopolysaccharides build up
in the
cells and cause irreparable
damage to organs, bones, the brain and
nerves.
Implantable prostheses designed to deliver electrical stimuli directly to the auditory
nerve hold considerable promise for people with a type of deafness
in which the sensory hair
cells of the inner ear are
damaged
Neuroscientists have long believed that scar tissue formed by glial
cells — the
cells that surround neurons
in the central nervous system — impedes
damaged nerve cells from regrowing after a brain or spinal cord injury.
Two weeks after the rats sustained their injuries, Schwartz's group found that the number of surviving
cells in the
damaged nerves of these rats was three times higher on average than
in rats with similar
damage that received a placebo injection.
If this happens
in nerve cells, for example, the clumped proteins can cause permanent
damage.
Six months ago, Michal Schwartz and her team at the Weizmann Institute of Science
in Rehovot, Israel, showed that another type of white blood
cell called a macrophage can help
damaged spinal
nerves grow back.
Researchers at the NRC have previously shown that gelatin accelerates brain tissue healing and reduces
damage to
nerve cells in the case of electrode implants, but only now are they starting to understand how.
A particular type of macrophage known as microglia are found throughout the brain and spinal cord —
in progressive forms of MS, they attack the CNS, causing chronic inflammation and
damage to
nerve cells.
Working with Tanz researcher Tetsuro Murakami and with colleagues at the University of Cambridge and Columbia University, they focused initially on the FUS protein, and discovered that these abnormal clumps could actually be a very important player
in causing
nerve cell damage and ALS.
These results support the hypothesis that that all the symptoms and disease courses observed
in MS patients are produced by the same underlying mechanisms that
damage nerve cells over time.
When researchers used a drug to block the action of the female sex hormone
in female mice carrying the Nf1 mutation, they saw a drop
in the number of activated microglia and a decrease
in retinal
damage and
nerve cell death.
The study showed that a peripheral
nerve injury
in rats sends a message from
damaged nerve cells to spinal cord immune
cells known as glial
cells, which normally act as «housekeepers» to clear out unwanted debris and microorganisms.
At the time, another neural prosthetic was just gaining traction: cochlear implants, which bypass
damaged cells in the inner ear to directly stimulate the auditory
nerve.
Now, Professor Martin and colleagues have discovered that
in response to specific types of
cell damage, Parkin can trigger the self - destruction of «injured»
nerve cells by switching on a controlled process of «cellular suicide» called apoptosis.
The Sheffield team led by Dr Kurt De Vos and Dr Andy Grierson investigated the role of the C9orf72 protein
in nerve cells and found it regulates the initiation of a vital process called «autophagy», which helps the
cell to dispose of
damaged proteins and
cell parts, and recycles
cell nutrients.
Methanol harms sight mainly by
damaging mitochondria
in cells in the eye's retina and optic
nerve.
In fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerv
In fact, so much of the progress that we're making
in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerv
in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic
nerve fibers all the way back to their targets
in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerv
in the brain, and even replace
damaged retinal ganglion
cells with self - therapies that completely rebuild the optic
nerve.
This
damages nerve cells by blocking their ability to make the proteins needed for synaptic function and leads to the death of neurons
in the brain and spinal cord.
Exposure to loud noises
damages the synapses connecting the
nerves and the hair
cells in the cochlea, resulting
in noise - induced hearing loss.
Nerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of Cambr
Nerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem
cells in the same way that they communicate with other
nerve cells, calling out for «first aid», according to new research from the University of Cambr
nerve cells, calling out for «first aid», according to new research from the University of Cambridge.