Sentences with phrase «damage to liver tissue»

In liver disease, excessive ROS triggers the activation of HSCs that, in turn, cause damage to liver tissues.

Not exact matches

Large quantities of these reverted cells could be used to treat anything from spinal cord injury to liver damage without the risk of tissue rejection, said Robert Weinberg, a biologist at the Massachusetts Institute of Technology's Whitehead Institute for Biomedical Research and co-author of a study appearing in Cell.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

One field that stands to benefit is tissue engineering, where the goal is to replace damaged biological tissues, such as in knee repairs or in creating artificial livers,» said Professor Subra Suresh, who will be assuming office as the NTU President on 1 January 2018.

Each participant was randomly allocated a donor liver that was either hooked up to the metra machine, or stored on ice — which slows down cellular metabolism to mitigate damage, but makes the organ prone to injury when blood supply returns to the tissue.

And by creating personalized organoids from the reprogrammed cells of patients, scientists could study disease in a very individualized way — or maybe even use organoid structures to replace certain damaged tissues, such as in the liver or spinal cord.

In the Rutgers study, Zong and lead author Ji - An Pan, a scientist in his laboratory, looked at liver and heart damage in laboratory mice and found that the mice in which the TRIM21 gene was inactivated suffered little heart or liver damage when put through the same laboratory procedures used to produce tissue damage in mice with the gene.

Rutgers scientists said this study indicates how critical it is to carefully control oxidative stress — which can also lead to neurodegenerative diseases like Parkinson's and Alzheimer's, chronic fatigue syndrome, cancers and gene mutations as well as liver and heart disease — so that cell or tissue damage doesn't occur.

Additionally, it caused no tissue damage or adhesions to surrounding tissues when applied to a liver hemorrhage in mice — side effects that were observed with both super glue and a commercial thrombin - based adhesive.

A team of researchers from the Massachusetts General Hospital (MGH) Center for Engineering in Medicine (MGH - CEM) have created a «liver on a chip,» a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive patterns of liver damage caused by exposure to environmental toxins, including pharmaceutical overdose.

«The livers were resistant to tissue damage and healed better, which are two good things — like playing offense and defense at the same time,» he said.

α1AT deficiency leads to chronic tissue breakdown and liver damage.

The method has broad potential applications, from creating healthy liver cells to replace damaged or diseased liver tissue to offering highly targeted drugs for individualized patient care.

The body sends cholesterol from the liver to places of inflammation and tissue damage to help repair it

In test animals, diets high in polyunsaturates from vegetable oils inhibit the ability to learn, especially under conditions of stress; are toxic to the liver; compromise the integrity of the immune system; depress the mental and physical growth of infants; increase levels of uric acid in the blood; cause abnormal fatty acid profiles in the adipose tissues: have been linked to mental decline and chromosomal damage and accelerate aging.

Rats fed protein - deficient diets have decreased DBP concentrations and a decreased ability to regulate calcium metabolism.38 Humans with acute liver failure also have depressed levels of DBP.39 This may be because the synthesis of DBP in the liver declines during such a condition, but DBP also plays a secondary role in scavenging harmful cellular debris from the blood; therefore, any kind of acute tissue damage can overwhelm our supply of DBP.

As well as helping you to lose weight, grow muscle and lose man boobs, eating liver will also increase your energy levels, increase stamina, speed up damaged tissue repair, curb sugar cravings, and help to protect your liver against the countless assaults it faces from all the chemicals we are exposed to in our food.

If you eat properly — which is really the only known good way to regulate LDL particle size — then it does the right thing; it takes the cholesterol to your tissues, the HDL takes it back to your liver, and nothing gets stuck causing damage.

NASH can eventually progress to end - stage liver disease known as cirrhosis, wherein damaged liver cells die off and are replaced by scar tissue that impairs function that can lead to liver failure or liver cancer.

And that's not all: Moringa leaves also have antioxidant activity that may protect the liver, kidneys, heart, and lungs tissues from damage, according to a 2015 review in Phytotherapy Research.

Lots of people promote taking essential oils internally, which I have personally never condoned, as they can be hard on the liver to process, and even do damage to tissues and organs.

They destroyed their ability to repair damaged tissue, gave them fatty liver, stopped their internal organs from developing, and if the rats encountered toxic substances, the diets dug them an early grave.

«It is important to understand the factors leading to impaired liver function — our lifestyle choices including poor diet, stress and lack of exercise, as well as exposure to environmental pollutants that produce tissue - damaging free radicals,» says Dr. Melissa Palmer, clinical professor and medical director of hepatology at New York University Plainview.

When you (or more specifically, a licensed medical practitioner) inject a prolotherapy solution — which can be anything from hyperosmolar dextrose (basically glorified sugar water) to glycerine, lidocaine, or even cod liver oil extract — you create a localized, controlled inflammatory process that stimulates the body's own repair mechanisms to heal the damaged tissue.

You're body is used to all these endogenous artificial testosterone, you know, your testosterone to estrogen ratio is getting messed up and so you do have to use what's called post cycle therapy when you're on pro-hormones and we won't get into the post cycle therapy as much on this podcast «cause I know we're kinda pushing for time but the problem is that if you don't cycle pro hormones, it can be tough on your liver, it can be tough on your own endogenous production so it's something that you do wan na make sure that you do, that you understand how to cycle properly and I have to be careful of course, giving out recommendations like that on this show just because so many people who are listening to this are competing in event like triathlons and marathons and thing of that nature where they're gonna be drug tested and stuff like this would be a big no - no anyways, you know, or they're going after more natural means and let's face it, prohormones can be kinda damaging to your body and the reason for that is because a lot of these side effects: acne and hair loss, breast tissue enlargement, or you know, what we affectionately call bitch tits in dudes, prostate swelling, you know, a lot of these hormonal imbalances that get created from dumping exogenous sources of hormones into your body and creating like a hormone milieu that can be a real real issue from a health standpoint.

This pineapple, lemon and ginger detox water improves liver functioning, gets rid of toxins in the body, improves skin health, improves immune system functioning, calms the mind, repairs damage to cells in the body, reduces inflammation, repairs tissues in the body, reduces stomach cramping, relieves gas and so much more.

If you eat properly, which is really the only known good way to regulate LDL particle size, then it does the right thing; it takes the cholesterol to your tissues, the HDL takes it back to your liver, and nothing gets stuck causing damage.

It is damaging to the liver, produces high levels of triglycerides circulating in the bloodstream and adds to adipose (fat) tissue in the body.

In this context, the term «primary» is used to denote that the condition is direct consequence of the accumulation of copper in the liver tissues and is a direct result of the presence of the inherited «copper accumulation» genes, i.e. it is not the consequence of a malfunction caused by another factor such as damage to the gall bladder which would impair the removal of bile and therefore copper.

Just one mothball has the potential to sicken a dog or cat and mothballs that contain naphthalene can cause serious illness, including digestive tract irritation, liver, kidney and blood cell damage, swelling of the brain tissues, seizures, coma, respiratory tract damage (if inhaled) and even death (if ingested).

The tissue sample will be examined under a microscope to determine the amount of copper in the liver and how much liver damage has already occurred.

Used in conjunction with milk - thistle, a nutraceutical supplement, these compounds are shown to decrease cell damage caused by biliary dysfunction and help the liver rebuild healthy functional tissue.

Mass lesions within the liver are often identified on ultrasound examination and can represent an area of liver healing (or regenerative nodule in a damaged region), a change in tissue content caused by storage of glycogen (starch, common in dogs with Cushing's Disease described below), infections (abscesses), biliary cysts, chronic fibrous tissue secondary to chronic hepatitis, or benign or malignant tumors.

ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)