Sentences with phrase «damage to nerve cells in»

SAN FRANCISCO, CA — Scientists at the Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis (MS)-- a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord.

The research suggests that elevated levels of urea in the brain may be an early feature of Huntington's disease, but it did not explore what might lead to elevated urea or whether urea contributes to damage to nerve cells in the disease.

Researchers at the NRC have previously shown that gelatin accelerates brain tissue healing and reduces damage to nerve cells in the case of electrode implants, but only now are they starting to understand how.

Not exact matches

His research shows that in cases of hearing loss, the ear's nerve fibers become damaged before the hair cells do, and when those synaptic fibers reconnect to the hair cells, it's possible to regain hearing.

[Robert Siman et al, Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Post Concussion Symptoms] A strong blow to the head causes chemical changes within nerve cells that damage their structural proteins.

In the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in micIn the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in micin mice.

In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirelIn a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirelin the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.

But their prominence at sites where nerve cells are damaged by the disease means they deserve careful scrutiny in the desperate search for ways to arrest the most salient cause of dementia.

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

These damaged cells fail to carry glucose into cells; instead glucose builds up in the blood and can damage nerves, blood vessels and organs unless insulin is administered.

Studies in rats and dogs have already demonstrated that olfactory ensheathing cells (OECs), which insulate bundles of nerve cells, can help repair damage to the spinal cord and nerves leading to animals» paws.

Others include transplanting so - called Schwann cells from peripheral nerves, using growth factors to stimulate nerve growth, and boosting the immune system in the damaged area (New Scientist magazine, 14 August 1999, p 36).

«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve tissue,» said Zhang.

Lou Gehrig's disease, also known as amyotrophic lateral sclerosis, or ALS, might damage muscle - controlling nerve cells in the brain earlier in the disease process than previously known, according to research from the Cedars - Sinai Board of Governors Regenerative Medicine Institute.

Based on previous studies, researchers have hypothesized that recreational noise exposure might damage the circuitry between sensory hair cells in the inner ear and their auditory nerve targets that deliver information to the brain.

Since Lipton's group co-discovered the SNO reaction some 20 years ago, scientists have linked the reaction to protein misfolding and nerve cell damage in cases of Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS / Lou Gehrig's disease) and Parkinson's disease, as well as heart / cardiovascular disease and cancer.

But if the HLA - A2 gene turns out to be the culprit, then the immune system is probably involved somehow in Alzheimer's symptoms, says Payami, perhaps by damaging nerve cells.

RIPK1, the researchers found, inflicts damage by directly attacking the body's myelin production plants — nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from damage.

According to the researchers, how nerve cells are damaged in these diseases has remained a mystery until now.

«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause damage to the eye, and then we also quantified the amount of nerve cell death in the back of the eye that mediates the optic neuropathy, and, lastly, we looked at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School.

As a result, mucopolysaccharides build up in the cells and cause irreparable damage to organs, bones, the brain and nerves.

Implantable prostheses designed to deliver electrical stimuli directly to the auditory nerve hold considerable promise for people with a type of deafness in which the sensory hair cells of the inner ear are damaged

A particular type of macrophage known as microglia are found throughout the brain and spinal cord — in progressive forms of MS, they attack the CNS, causing chronic inflammation and damage to nerve cells.

When researchers used a drug to block the action of the female sex hormone in female mice carrying the Nf1 mutation, they saw a drop in the number of activated microglia and a decrease in retinal damage and nerve cell death.

The study showed that a peripheral nerve injury in rats sends a message from damaged nerve cells to spinal cord immune cells known as glial cells, which normally act as «housekeepers» to clear out unwanted debris and microorganisms.

At the time, another neural prosthetic was just gaining traction: cochlear implants, which bypass damaged cells in the inner ear to directly stimulate the auditory nerve.

Now, Professor Martin and colleagues have discovered that in response to specific types of cell damage, Parkin can trigger the self - destruction of «injured» nerve cells by switching on a controlled process of «cellular suicide» called apoptosis.

The Sheffield team led by Dr Kurt De Vos and Dr Andy Grierson investigated the role of the C9orf72 protein in nerve cells and found it regulates the initiation of a vital process called «autophagy», which helps the cell to dispose of damaged proteins and cell parts, and recycles cell nutrients.

In fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nervIn fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nervin laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nervin the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerve.

This damages nerve cells by blocking their ability to make the proteins needed for synaptic function and leads to the death of neurons in the brain and spinal cord.

Exposure to loud noises damages the synapses connecting the nerves and the hair cells in the cochlea, resulting in noise - induced hearing loss.

Nerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of CambrNerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of Cambrnerve cells, calling out for «first aid», according to new research from the University of Cambridge.

A series of six cell culture assays was designed to mimic multiple old - age - associated pathways of central nervous system (CNS) nerve cell damage, and drug candidates were required to show efficacy in all of these assays before being moved forward into animals.

By this, researchers demonstrated that a peripheral nerve injury in rats would send a message from the damaged nerve cell to special spinal cord immune cells called «glial cells».

Doctors at Okyanos utilize a specifically developed Okyanos protocol for opening up the blood brain barrier to help deliver stem cells directly to the brain; a technique that has been proven effective in independent studies This enables doctors to target your stem cells inside the brain to re-establish blood flow and repair damaged nerve cells (neurons) as well as target the restoration of myelin, halting the future progression of symptoms.

As a result, the mice failed to show the type of progressive nerve cell damage seen in MS.

In some instances of damage to the nigrastriatal axis, such as methamphetamine toxicity, the cell bodies of SNpc dopaminergic neurons remain alive while their nerve terminals in the striatum degenerate (Ricaurte et al., 1982In some instances of damage to the nigrastriatal axis, such as methamphetamine toxicity, the cell bodies of SNpc dopaminergic neurons remain alive while their nerve terminals in the striatum degenerate (Ricaurte et al., 1982in the striatum degenerate (Ricaurte et al., 1982).

For more than a century, scientists thought that glial cells were responsible for scar formation; now, however, a paper published in Science shows that spinal cord scar tissue largely derives from a completely unexpected type of cell called a pericyte, opening new opportunities for the treatment of damaged nerve tissue.Lesions to the brain or spinal cord rarely heal fully, which leads to permanent functional impairment.

It is now almost routine to grow skin cells from a patient with, say, a neurological disease; turn them into pluripotent cells in a Petri dish; convert the cells into nerve cells to study the disease process; and contemplate using the cells to repair the same patient's damaged brain.

Because nerve cells, which send electrical impulses and neurotransmitters (think serotonin and dopamine), are rich in DHA, omega - 3s protect nerve cells from damage and indemnify normal, healthy communication between brain cells and the body's nerves, which can impact mood and ha been linked to depression severity.

This can result in major damage to cells and could be a key prerequisite for Parkinson's disease's characteristic nerve damage.

With the ability to quadruple in numbers every 20 - 24 hours, chlorella has been shown to possibly repair damage to nerve tissues and aid in cell production.

Too much sorbitol trapped in retinal cells, the cells of the lens, and the Schwann cells that myelinate peripheral nerves can damage these cells, leading to retinopathy, cataracts and peripheral neuropathy, respectively.

It is recommanded to take Alpha Lipoic Acid with Acetyl L Carnitine as in studies they both seemed to worked even better in slowing down ageing process and regenerating damaged nerves and mitochondria (cell's power stations)!

You've already learned about the importance of fat, so as you can probably imagine, fat deficiencies can also result in poor blood sugar control, inability to repair central nervous system damage, poor nerve cell function, low hormone production, low antioxidant levels, and many other issues.

Transmission electron microscopy with colloidal gold immunocytochemistry showed structural damage in young and aged microvessel endothelium of ApoE4 animals extended to the cytoplasm of perivascular cells, perivascular nerve terminals and hippocampal neurons and glial cells.

Instead of being transported to other cells for energy, sugar builds up in the bloodstream and can contribute to nerve damage, artery hardening, and heart attack.

If we place them in and around a damaged spinal cord they have the potential to form nerves and the supporting cells that help nerves heal.

The paralysis is sometimes the result of a traumatic brain injury that damages the myelin sheath of the nerve cells; locked - in syndrome is caused by damage to the brain's vertical pons, a region that controls voluntary movement.