Paralysis can occur as a result of any type of injury that causes
damage to the nerve fibers that transmit impulses from the brain out to the limbs and the organs of the body.
During such an injury, the brain bumps back and forth inside skull, resulting in bleeding, bruising, and
damage to nerve fibers.
Not exact matches
His research shows that in cases of hearing loss, the ear's
nerve fibers become
damaged before the hair cells do, and when those synaptic
fibers reconnect
to the hair cells, it's possible
to regain hearing.
«Moving
to non-invasive and repeatable methods of
nerve fiber measurements such as in vivo corneal confocal microscopy would enhance study of peripheral neuropathy by enabling early detection of
damage, progression of
nerve fiber deterioration, and enable assessment of therapeutic strategies in the SIV / macaque model,» explains Dr. Mankowski.
Studies have shown that corneal
nerve fiber density, measured by confocal microscopy, can predict diabetes - related
damage to the peripheral
nerves, called peripheral neuropathy.
«The cornea is the most densely innervated tissue in the body, so corneal
nerve assessment is extremely sensitive for detecting small sensory
nerve fiber damage as compared
to other tests including measurement of intra-epidermal
nerve fibers in the skin,» notes lead investigator Joseph L. Mankowski, DVM, PhD, who is Professor of Molecular and Comparative Pathobiology, Pathology, and Neurology at the Johns Hopkins University School of Medicine, Baltimore, MD..
Electrophysiological testing
to measure peripheral
nerve conduction properties is not a viable alternative because current methods lack the sensitivity required
to detect
damage to small, unmyelinated
fibers, especially in early stages of disease.
Therefore, new sensitive, noninvasive methods of assessing small
fiber nerve damage are urgently needed
to detect and monitor peripheral neuropathy in HIV - infected individuals.
Both are released at elevated levels following a concussion or other injury that
damages nerve fibers, and both can be detected within 20 minutes of a head injury (although it may take longer for doctors and patients
to get the results from a lab).
The impact from a single heading is unlikely
to cause traumatic brain
damage such as laceration of
nerve fibers.
A study by researchers at Henry Ford Hospital found «substantial evidence» that a regenerative process involving
damaged nerve fibers in the spinal cord could hold the key
to better functional recovery by most stroke victims.
In fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic
nerve fibers all the way back
to their targets in the brain, and even replace
damaged retinal ganglion cells with self - therapies that completely rebuild the optic
nerve.
It can connect
to nerve fibers, but it can not make new ones - a concern for patients with severe
nerve damage.
We seek
to determine whether a particular type of imaging, known as «polarization - sensitive» imaging, is capable of reporting on the integrity of sub-microscopic structures within optic
nerve fibers at an early stage of
damage from glaucoma, preceding their complete degeneration and loss from the eye.
The underlying
nerve fiber is also
damaged as a result, interrupting the
nerve cells» ability
to transmit signals and do their job.
We seek in this proposal
to determine whether a particular type of imaging is capable of assessing and reporting on the integrity of sub-microscopic structures within optic
nerve fibers at an early stage of
damage preceding their complete degeneration and loss from the eye.
Current clinical gold - standard methods for assessing the structural integrity of
nerve fibers damaged by glaucoma are only able
to detect complete loss of those
fibers from the retinal layer within the eye.
Over time, the resulting bouts of inflammation permanently
damage the myelin sheath and the
nerve fibers it protects, disrupting
nerve signals traveling
to and from the brain.
In addition
to slowing down the metabolism, organophosphates «can seriously impair a person's ability
to exercise, permanently
damaging nerves, destroying muscle
fiber, reducing the body's ability
to fuel exercise, and even reduce a persons desire
to exercise,» adds Dr. Baillie - Hamilton.
A small
fiber neuropathy occurs when
damage to the peripheral
nerves predominantly or entirely affects the small myelinated (Aδ)
fibers or unmyelinated C
fibers.
When an injury is inflicted
to the spinal cord or its vertebrae, the
nerve fibers in the spinal cord are
damaged, leaving the brain unable
to send the right messages
to other parts of the body.