Sentences with phrase «damaged by a mutation»

Not exact matches

These structural and functional differences are not seen when cells are placed in similar positions by mutation or laser - induced damage.

Such tests, however, have mysteriously failed to flag mutations in 20 % to 30 % of European women with a family history of breast cancer, even when their cancer could be linked to BRCA1 by damage to chromosome 17, BRCA1's home.

ALD, for instance, is caused by mutations in a gene called ABCD1, leading to unusually high levels of a type of fatty acid that damages the material insulating some neurons.

Now, results described in tomorrow's issue of Nature suggest that BRCA2 mutations could lead to cancer by interfering with cells» ability to repair damaged DNA.

Rare, deadly, and caused by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.

Conventional risk models used by NASA and others assume DNA damage and mutation are the cause of radiation cancers.

Rather than artificially triggering cancer by engineering genetic mutations, this model more closely mimics human liver cancer in that tumors develop as a natural consequence of non-alcoholic steatohepatitis (NASH), a chronic metabolic disorder that causes liver damage, fibrosis and numerous cell mutations.

They found that the inactivation of POT1 caused by these mutations leads to longer and potentially unprotected telomeres, regions at the end of our chromosomes that protect chromosomes from damage.

Most mutations are caused by chemical or radiation damage from the immediate environment or within the cell itself.

However, the new findings suggest the possibility of treatments that would prevent neuronal damage by restoring the healthy balance of phase separation in the cells of people with ALS / FTD mutations.

«But we are hopeful that our technique, by treating the human genome like lines of computer code, could one day be used to reverse these harmful mutations, and essentially repair the damaged code.»

They think this gene hub could be targeted with drugs to correct some of the damage caused by GATA4 mutations.

Mutations in tau cause neurodegeneration in human brains, and tau modified by the addition of phosphate groups (p - tau) forms aggregates and damages neurons.

Caused by a mutation in the gene for a protein called huntingtin, the disease damages brain cells so that people with Huntington's progressively lose their ability to walk, talk, think and reason.

They then identified damaging mutations in the children that would disable the protein produced by a particular gene or alter the protein's function.

In the process, it gained additional mutations, possibly via the DNA damage induced by chemotherapy.

This suggests that the absence of DJ - 1 was unlikely to have strongly accelerated mtDNA damage caused by the Polg mutation, although we can not exclude a more subtle effect.

The accuracy of next - generation sequencing (NGS) for detecting tumor - specific mutations in plasma DNA is hindered by errors introduced during PCR / sequencing, base substitutions caused by DNA damage, and pre-existing mutations in normal cells that are present at a low frequency.

By performing a meta - analysis of rare coding variants in whole - exome sequences from 4,133 schizophrenia cases and 9,274 controls, de novo mutations in 1,077 family trios, and copy number variants from 6,882 cases and 11,255 controls, we show that individuals with schizophrenia carry a significant burden of rare, damaging variants in 3,488 genes previously identified as having a near - complete depletion of loss - of - function variants.

Such diseases are believed to be initiated by mutations and rearrangements of the DNA sequence.DNA damage generated by ionising radiation, simple alkylating agents or endogenously hydrolytic and oxidative processes is corrected by the base excision repair (BER) pathway.

Cancer causing mutations may be due to impaired mitochondrial metabolism by the production of reactive oxidative species that cause DNA damage.

Oxidative stresses induced by free radicals cause DNA damage, which, when left unrepaired, can lead to base mutation, single and double strand breaks, DNA cross-linking, and chromosomal breakage and rearrangement.

Antioxidants fight disease by destroying free radicals, which can cause cell damage that results in the mutations that often lead to arthritis, dementia, and even cancer.

By getting rid of free radicals, antioxidants can protect your dog's cells from damage that may lead to dangerous mutations.

Praised by critics as being a return to the series» horror roots (especially due to the limited ammo and guns), Resident Evil Revelations takes place between RE4 and RE5, and features fan favorites Chris Redfield and Jill Valentine as they battle horrific mutations on a boat and in the damaged city of Terragrigia.

The mutations include one that causes enemies to freeze and die instantly when knocked by Aard, one that makes enemies to explode when they're killed with a sign's critical hit, and another that heals and grants you damage immunity when you lose all of your health.

For instance, Oscar Mike's first mutation I unlocked allows him to choose a new ability at level seven (in this case, I could choose to increase his basic assault rifle damage by 17 %, which goes a long way in competitive).