Not exact matches
«We found that in young healthy
mice the immune system overreacted to the influenza virus, which led to more inflammation, greater
lung damage and increased mortality compared to healthy adults exposed to the virus,» says lead author Bria Coates, MD, Critical Care physician at Ann & Robert H. Lurie Children's Hospital
of Chicago and Assistant Professor
of Pediatrics at Northwestern University Feinberg School
of Medicine.
«The virus penetrates more deeply into the
lungs of obese
mice, and the animals seem to have a more difficult time repairing the
damage,» Schultz - Cherry said.
Mice who couldn't produce CHI3L1 / BRP -39, had acute
lung cell
damage, somewhat like AE patients who have a relative deficiency
of CHI3L1.
Copeland's team also noted that these
mice suffered from a host
of immune - related problems, the most crippling being a flood
of macrophages — a type
of white blood cell —
damaging the
lungs and other organs.
One 2003 study revealed that carbon nanotubes could
damage the
lungs of rats and
mice.
To measure the differences in immune system function between the two groups
of older
mice, the researchers examined the
lungs to assess
damage, counted the number
of bacteria in the
lungs, and calculated the number
of the white blood cells (neutrophils).
The reduced numbers
of bacteria and white blood cells resulted in less
lung damage in the older
mice who received extra vitamin E.
Exposure to linalool, a terpene found in flowers and spice plants, decreased inflammatory
damage in the
lungs of smoke - exposed
mice.12 Linalool is found in lavender and basil, and in keeping with terpenes ability to defend against plant prey, is used by exterminators as an insecticide.
The researchers counted the number
of damaged cells in the
mice's
lungs, and calculated a Pathology score based on this.