The Merck Veterinary Manual states that, «The cause [of dilated cardiomyopathy in dogs] is still unknown although viral infection and resultant autoimmune reaction against
the damaged myocardium are suspect....
More interestingly, the effects on infarction size, survival rates and cardiac function can be observed even if the dietary intervention is induced after the ischemic event, by increasing the expression of angiogenic factors and increased vascularization of
the damaged myocardium, proposing a novel non-pharmacological therapy for subjects with chronic heart failure (43).
In pre-clinical experiments, hESC - derived cardiomyocytes engraft in
damaged myocardium and appear to behave like native cells; hESC - derived islet cells engraft, produce the hormones of the endocrine pancreas, and appear to do so under homeostatic control; etc. \ n \ nThere is no evidence of teratomas from differentiated hESC - derived cells and minimal, if any, immune rejection.
Not exact matches
Stem cells affect the infarcted
myocardium via neovascularization, reduction of apoptosis and paracrine effect, they are able to increase myocardial perfusion, inhibit synthesis of pro-inflammatory cytokines (IL6 and TNFα) and promote expression of anti-inflammatory cytokines (IL10) minimizing the necrosis
damage caused by local inflammatory reaction.
The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause
damage or death (infarction) of heart muscle tissue (
myocardium).
† Myocardial Infarction (MI, Acute Myocardial Infarction, AMI, Non-ST Segment Elevation Myocardial Infarction, STEMI, Heart Attack): An acute interruption of vascular perfusion of any portion of the
myocardium (muscles of the heart) due to either an occlusion of a coronary artery or to vascular spasm causing
damage to the
myocardium.