GenSight's treatment is for people with
damaged photoreceptor cells but intact ganglion cells; it inserts the gene into the ganglion cells, whose axons form the basis of the optic nerve.
The artificial retina then converts the signal into electrical impulses, which bypass
damaged photoreceptors and stimulate the retina's remaining cells.
Such technologies generally use a camera to detect visual information that is relayed to an implant inside the eye, which effectively replaces
the damaged photoreceptors.
Not exact matches
In people with these conditions the
photoreceptors, which transform light hitting the eye into electrical impulses, are
damaged, preventing the brain from receiving image information.
In people with RP and AMD, the
photoreceptors have been
damaged and lost, so the ganglion cells do not receive signals and the brain can not produce an image.
THERE are
photoreceptors in your skin like those in your eye, allowing your body covering to mount a swift defence against
damaging ultraviolet radiation.
Bypassing
damaged retinal cells The light - sensitive
photoreceptors made by the rod and cone cells in the retina also belong to the GPCR class.
In people with these conditions the retina's
photoreceptors — which transform light hitting the eye into electrical impulses — are often
damaged, preventing visual information from being sent to the brain.
Functional
damage to these
photoreceptors, or pathological loss of the cells that bear them, results in inability to register light impinging on the retina — and is responsible for various types of visual impairment and certain forms of congenital blindness.
They play a pivotal role in regulating synaptic transmission, modulating excitotoxicity responsible for much of the neuronal
damage caused by hypoxic insult in the brain [37], and are expressed in retinal
photoreceptors, horizontal cells, and bipolar cells as well as the amacrine and ganglion cells of the inner retina [38 — 41].
In retinal diseases such as age - related macular degeneration, for example,
photoreceptor cells that absorb light signals are
damaged or dead.
Neves confirmed that MANF is indeed upregulated in response to retinal
damage in both the fly and the mouse, and protects
photoreceptors from different types of
damage.
Helps protect against light - induced oxidative
damage of
photoreceptors.