Sentences with phrase «damaged proteins accumulate»

But over the years, as damaged proteins accumulate in the lens, these chaperones become overwhelmed.

Not exact matches

But in her doctoral dissertation under the guidance of Prof. Glickman, Dr. Daria Krutauz found that in the presence of UBB +1, damaged proteins are apprehended on their way to the proteasome, and accumulate without reaching their final recycling destination.

In Alzheimer's disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons.

What these illnesses have in common is that they're caused by abnormal proteins that accumulate in or between brain cells to form plaques, producing damage that causes mental decline and early death.

These stressors can also cause XBP - 1s to accumulate in the cell's nucleus, which promotes the UPR and helps cells withstand the damaging effects of mis-folded proteins.

This defective mutant gene causes production of a toxic protein that progressively accumulates and damages the patient's neurons.

In Alzheimer's, this protein — present in all healthy brains — can accumulate and clump, developing into cell - damaging plaque.

The scientists think that phosphorylation enables neurons to remove more of the harmful protein so it does not accumulate and damage the cell.

Moreover, some scientists suggest, that the damage of the DNA and the corresponding with it «wrong proteins» is a main factor for the accumulation of «all the cellular gunk», and they suppose, that even after the removal of the «gunc», it will accumulate again if the DNA remains damaged.

«One of the hypotheses is that during the aging process, the loss of proteostasis causes protein damage, which begins to accumulate.

These proteins can not be gotten rid of, so the protein accumulates, and the A.G.E.s accumulate and continue to damage.

Results showed significant reductions in oxidized proteins and lipids — molecules that had been damaged by accumulated toxins and waste products.