Sentences with phrase «damaged proteins as»

Not exact matches

But in the lab, when the scientists manipulated human cells to be able to create the water bear shielding protein — called Dsup — they showed about half the DNA damage as normal cells.

This changes a lot of what scientists thought they knew about how water bears deal with radiation, as they were previously thought to have proteins that repaired damaged DNA, rather than proteins that halt damage altogether.

That's because the body is breaking down old, damaged proteins and building new ones, which is a process called protein breakdown and protein synthesis, known collectively as protein turnover.

It must be noted, however, that there are injurious grain proteins that cause damage and produce symptoms by mechanisms that are as yet obscure.

As for the microwaves damaging your food, it does so no more than any other cooking method (all heating of food will damage proteins and enzymes, but your stomach does the same thing!

Joseph Mercola's new book «Fat For Fuel» has extremely good information on the importance of keeping a tight control on protein (as well as carbs) because of the damage they can cause to mitochondria — in fact he steers clear of almonds for that reason.

The reality is not «gentle proteins», cute pink hearts or «probiotics just like those in breastmilk» but dirty contaminated bottles, diarrhea, babies screaming with pain from otitis media, babies separated from their mothers in pediatric wards with acute respiratory disease, damaged guts that morph into chronic lifelong conditions such as Crohn's disease, more women dying of breast cancer, the cost and pain of living a life with diabetes and lives cut short because of cardiac disease and so on.

The latter ties overproduction of free radicals to oxidative damage to lipids, proteins, and DNA, leading to chronic diseases such as atherosclerosis, cancer, diabetes, and rheumatoid arthritis.

Other proteins such as histones are involved in the packaging of DNA or repairing the damage to DNA that causes mutations.

Among those are proteins that contribute to the production of seeds, as well as proteins involved in defending cells from heavy metal and radiation damage.

One is that the cancer - related proteins used by the test reflect tissue damage and can also appear in people with inflammatory diseases such as arthritis.

In a report on their study, published June 20 as an Early View article online in Annals of Neurology, the Johns Hopkins team found that increasing levels of the protein clumps corresponded with worsening nerve damage, indicating that the smaller skin biopsies they used appear to work well as a measure of disease severity.

A common feature of neurodegenerative diseases such as Alzheimer's, Parkinson's or Huntington's disease are deposits of aggregated proteins in the patient's cells that cause damage to cellular functions.

Current research is looking at why inhibiting certain molecules, such as mouse protein Stat3, promote muscle regeneration in mice and how to engineer orthopedic implants from stem cells to replace damaged cartilage and bone, but the results of that effort aren't expected to be necessarily aimed at the old.

An earlier study indicated that the intermediate step was likely a floppy loop area formed by proteins, which didn't seem compatible with the tough, damaging fibril as an end result.

Arising from the abnormal buildup of a protein known as alpha - synuclein in the brain, such conditions damage the nerves that control blood pressure and heart rate.

Autophagy is also used for self - cleaning to eliminate other proteins as well as damaged or unneeded cellular components.

Generally, as an organism ages, not only are there more damaged proteins in need of disposal, but the proteasome itself becomes damaged and less efficient in clearing out the damaged proteins.

The protein itself has been known to researchers for some time as a result of research on zebrafish, where it plays an important role in the healing process following damage to the spinal cord.

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.

As researchers develop drugs that target the DUX4 protein, the hope is that these mice will be used to determine whether such drugs can reach skeletal muscle and allow muscle damage to be repaired, even in the presence of DUX4.

In aging, this gene expression presumably occurs to compensate for the accumulation of protein damages; during diapause, the same genes may be activated to prepare the whole embryo to catch up with the interrupted development and be ready to hatch as the rainy season starts.

As study director Brack - Werner explained: «Several viral proteins are toxic to neurons and may cause immune damage in the brain.

Since Lipton's group co-discovered the SNO reaction some 20 years ago, scientists have linked the reaction to protein misfolding and nerve cell damage in cases of Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS / Lou Gehrig's disease) and Parkinson's disease, as well as heart / cardiovascular disease and cancer.

Misshapen proteins become entangled with neurons in prion diseases such as Creutzfeldt - Jakob disease, damaging or killing cells.

Just as oxygen can rust iron that makes up a horseshoe or frying pan, it can damage the iron - and - sulfur proteins of the photosynthetic apparatus.

RIPK1, the researchers found, inflicts damage by directly attacking the body's myelin production plants — nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from damage.

As expected, the antioxidants did reduce damage to DNA but also reduced levels of p53, an essential protein that suppresses...

That's good for probing delicate samples, such as proteins, than can be damaged by high - intensity light.

In research published in Molecular Cell, Rutgers scientists discovered that a protein (p62), which is supposed to act as an antioxidant to prevent cell damage, was not working efficiently in laboratory mice with liver and heart disease that mimicked these conditions in humans.

CD74 is broken into products that fit into the groove of cell surface immune response proteins as part of the chain of events that activates T cells — immune cells that normally attack infected (or damaged) cells in the body.

Inside these cells is a protein called alpha - synuclein, which is known to go awry and lead to damaging clumps in the brains of Parkinson's patients, as well as those with Alzheimer's disease.

In 2011, UT Southwestern researchers in Dr. Levine's laboratory identified the protein Smurf1 as important for the elimination of viruses and damaged mitochondria from cells via a cellular housekeeping process called autophagy.

This could be one of the mechanisms responsible for the reduced regeneration capacity in the aged brain as stem cells that retain larger amounts of damaged proteins require longer for the next cell division.

The researchers were able to model the characteristics of A-T in the laboratory, such as the cell's lack of ATM protein and inability to repair DNA damage.

When such DNA damage occurs, proteins known as PARPs move to the site of damage and begin to mend these broken strands of DNA, allowing cancerous cells and tumors to recover, grow and proliferate, thereby escaping the effects of treatment.

But over the years, as damaged proteins accumulate in the lens, these chaperones become overwhelmed.

But until he understands how the cells are stressed in the first place, he won't know much: «We frankly don't have a clue as to how much microwave radiation is needed to cause irreversible damage to cellular proteins.

Johns Hopkins University biologists have found that a protein that plays a key role in the lives of stem cells can bolster the growth of damaged muscle tissue, a step that could potentially contribute to treatments for muscle degeneration caused by old age and diseases such as muscular dystrophy.

He then explains how x-rays from NSLS - II can provide new capabilities to study proteins — as they jiggle and wiggle — to learn more about them, including their remarkable roles in repairing damaged DNA.

As luck would have it, cells in the brain called microglia act as the brain's street sweeper, zapping infectious agents, damaged cells, and, importantly, protein tangles and plaques that are thought to cause dementiAs luck would have it, cells in the brain called microglia act as the brain's street sweeper, zapping infectious agents, damaged cells, and, importantly, protein tangles and plaques that are thought to cause dementias the brain's street sweeper, zapping infectious agents, damaged cells, and, importantly, protein tangles and plaques that are thought to cause dementia.

At the same time, when mice that lacked the RGS6 protein were treated chronically with alcohol, they experienced less damage to heart and liver as well as the lining of the gut compared to mice with the protein.

As the DNA replication process unzips the DNA and becomes blocked by DNA damage, sometimes a motor protein recognizes the stall.

When this vasculature — the blood - brain barrier (BBB)-- ruptures, blood proteins can enter into the brain and cause edema and neuronal damage in a variety of neurological diseases, such as stroke, multiple sclerosis, Alzheimer's disease, and spinal cord injury.

The protein p53 is a key activator of the cell's protective machinery against genetic damage, such as the mutations that drive cancer cells» explosive growth.

A large variety of methods is used including genetic, molecular and cytogenetic techniques, fluorescence in situ hybridisation and DNA «combing», as well as high throughput sequencing approaches such as DNA - seq for mutation landscape analyses, RNA - seq for transcriptome analyses and ChIP - seq mapping of chromatin - associated proteins and their genome - wide modulation in response to DNA damages.

Bradshaw PS, Stavropoulos DJ, Meyn MS. Human telomeric protein TRF2 associates with genomic double - strand breaks as an early response to DNA damage.

Persistent DNA damage and DDR signaling triggers senescent cells to secrete immunomodulatory proteins, a phenomenon known as the senescence - associated secretory phenotype (SASP).

The proteins and other constituents of our cells are all eventually damaged as the result of biochemical accidents that occur during normal metabolism, or simply outlive their usefulness.