Sentences with phrase «damages nerve cells in»

Huntington's disease is a genetic disorder that affects around 1 in every 10,000 people and damages nerve cells in the brain.

Do these antibodies simply function like drugs in the brain or do they «attack» and damage nerve cells in some ways?»

Not exact matches

His research shows that in cases of hearing loss, the ear's nerve fibers become damaged before the hair cells do, and when those synaptic fibers reconnect to the hair cells, it's possible to regain hearing.

This damages some of the nerve cells in the brain, and affects my dad's memory, decision - making and personality.

[Robert Siman et al, Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Post Concussion Symptoms] A strong blow to the head causes chemical changes within nerve cells that damage their structural proteins.

The study, published Feb. 5 in Nature Neuroscience, showed that the patients» nerve cells — converted directly from patients» skin cells — exhibited «symptoms» of the disorder, including DNA damage, dysfunctional mitochondria and cell death.

In the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in micIn the new study, Zigmond and colleagues found damaged nerve cells produce a stream of molecular lures that specifically attract neutrophils to injury sites in micin mice.

Levels of a nerve cell signaling molecule called substance P — measured in tear samples — might be a useful marker of diabetes - related nerve damage (neuropathy), suggests a study in the July issue of Optometry and Vision Science, the official journal of the American Academy of Optometry.

In a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirelIn a study published in the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirelin the Journal of Neuroscience, researchers from Case Western Reserve University School of Medicine showed certain immune cells — neutrophils — can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.

They also found AXIN2 in the damaged nerve cells of adults with multiple sclerosis, a disease in which the immune system attacks myelin.

But their prominence at sites where nerve cells are damaged by the disease means they deserve careful scrutiny in the desperate search for ways to arrest the most salient cause of dementia.

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

«The compounds identified in this study, when administered orally, both reduced the inflammation that is a hallmark of multiple sclerosis and protected against the nerve cell damage seen in mouse models of the disease,» said Jeffery Haines, PhD, a post-doctoral fellow at Mount Sinai and the study's lead author.

These damaged cells fail to carry glucose into cells; instead glucose builds up in the blood and can damage nerves, blood vessels and organs unless insulin is administered.

Studies in rats and dogs have already demonstrated that olfactory ensheathing cells (OECs), which insulate bundles of nerve cells, can help repair damage to the spinal cord and nerves leading to animals» paws.

Others include transplanting so - called Schwann cells from peripheral nerves, using growth factors to stimulate nerve growth, and boosting the immune system in the damaged area (New Scientist magazine, 14 August 1999, p 36).

«Our data clearly showed that one of the protein receptors on white blood cells called CXCR3 brings white blood cells to the optic nerve in response to production of its binding partner CXCL10 by damaged nerve tissue,» said Zhang.

Lou Gehrig's disease, also known as amyotrophic lateral sclerosis, or ALS, might damage muscle - controlling nerve cells in the brain earlier in the disease process than previously known, according to research from the Cedars - Sinai Board of Governors Regenerative Medicine Institute.

Other scientists have shown that tamoxifen and similar drugs might also reduce nerve cell damage in the spinal cord and brain.

Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system.

Based on previous studies, researchers have hypothesized that recreational noise exposure might damage the circuitry between sensory hair cells in the inner ear and their auditory nerve targets that deliver information to the brain.

In a study led by Duke Health and published in the journal Alcoholism: Clinical and Experimental Research, scientists demonstrate in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young braiIn a study led by Duke Health and published in the journal Alcoholism: Clinical and Experimental Research, scientists demonstrate in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young braiin the journal Alcoholism: Clinical and Experimental Research, scientists demonstrate in rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young braiin rats that a short duration of the drug donepezil can reverse both structural and genetic damage that bouts of alcohol use causes in neurons, or nerve cells, in the young braiin neurons, or nerve cells, in the young braiin the young brain.

Since Lipton's group co-discovered the SNO reaction some 20 years ago, scientists have linked the reaction to protein misfolding and nerve cell damage in cases of Alzheimer's, Huntington's, amyotrophic lateral sclerosis (ALS / Lou Gehrig's disease) and Parkinson's disease, as well as heart / cardiovascular disease and cancer.

By reinsulating damaged nerves and regenerating nerve cells, Schwann cell transplants have earned their stripes in paralyzed mouse, pig and primate studies over the past decade.

One such treatment is already under development for testing in humans after the current study showed it stopped nerve cell damage in mice with ALS.

But if the HLA - A2 gene turns out to be the culprit, then the immune system is probably involved somehow in Alzheimer's symptoms, says Payami, perhaps by damaging nerve cells.

RIPK1, the researchers found, inflicts damage by directly attacking the body's myelin production plants — nerve cells known as oligodendrocytes, which secrete the soft substance, rich in fat and protein that wraps around axons to support their function and shield them from damage.

According to the researchers, how nerve cells are damaged in these diseases has remained a mystery until now.

«We used a mouse model of the KPro to, first of all, identify the inflammatory factors that cause damage to the eye, and then we also quantified the amount of nerve cell death in the back of the eye that mediates the optic neuropathy, and, lastly, we looked at blocking these factors with antibodies,» said Reza Dana, M.D., M.Sc., MPH, Director of the Cornea and Refractive Surgery Service at Massachusetts Eye and Ear and the Claes H. Dohlman Professor of Ophthalmology at Harvard Medical School.

As a result, mucopolysaccharides build up in the cells and cause irreparable damage to organs, bones, the brain and nerves.

Implantable prostheses designed to deliver electrical stimuli directly to the auditory nerve hold considerable promise for people with a type of deafness in which the sensory hair cells of the inner ear are damaged

Neuroscientists have long believed that scar tissue formed by glial cells — the cells that surround neurons in the central nervous system — impedes damaged nerve cells from regrowing after a brain or spinal cord injury.

Two weeks after the rats sustained their injuries, Schwartz's group found that the number of surviving cells in the damaged nerves of these rats was three times higher on average than in rats with similar damage that received a placebo injection.

If this happens in nerve cells, for example, the clumped proteins can cause permanent damage.

Six months ago, Michal Schwartz and her team at the Weizmann Institute of Science in Rehovot, Israel, showed that another type of white blood cell called a macrophage can help damaged spinal nerves grow back.

Researchers at the NRC have previously shown that gelatin accelerates brain tissue healing and reduces damage to nerve cells in the case of electrode implants, but only now are they starting to understand how.

A particular type of macrophage known as microglia are found throughout the brain and spinal cord — in progressive forms of MS, they attack the CNS, causing chronic inflammation and damage to nerve cells.

Working with Tanz researcher Tetsuro Murakami and with colleagues at the University of Cambridge and Columbia University, they focused initially on the FUS protein, and discovered that these abnormal clumps could actually be a very important player in causing nerve cell damage and ALS.

These results support the hypothesis that that all the symptoms and disease courses observed in MS patients are produced by the same underlying mechanisms that damage nerve cells over time.

When researchers used a drug to block the action of the female sex hormone in female mice carrying the Nf1 mutation, they saw a drop in the number of activated microglia and a decrease in retinal damage and nerve cell death.

The study showed that a peripheral nerve injury in rats sends a message from damaged nerve cells to spinal cord immune cells known as glial cells, which normally act as «housekeepers» to clear out unwanted debris and microorganisms.

At the time, another neural prosthetic was just gaining traction: cochlear implants, which bypass damaged cells in the inner ear to directly stimulate the auditory nerve.

Now, Professor Martin and colleagues have discovered that in response to specific types of cell damage, Parkin can trigger the self - destruction of «injured» nerve cells by switching on a controlled process of «cellular suicide» called apoptosis.

The Sheffield team led by Dr Kurt De Vos and Dr Andy Grierson investigated the role of the C9orf72 protein in nerve cells and found it regulates the initiation of a vital process called «autophagy», which helps the cell to dispose of damaged proteins and cell parts, and recycles cell nutrients.

Methanol harms sight mainly by damaging mitochondria in cells in the eye's retina and optic nerve.

In fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nervIn fact, so much of the progress that we're making in laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nervin laboratories, including mine, is on developing neuroprotective therapies that can protect the retina from degeneration, regenerate optic nerve fibers all the way back to their targets in the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nervin the brain, and even replace damaged retinal ganglion cells with self - therapies that completely rebuild the optic nerve.

This damages nerve cells by blocking their ability to make the proteins needed for synaptic function and leads to the death of neurons in the brain and spinal cord.

Exposure to loud noises damages the synapses connecting the nerves and the hair cells in the cochlea, resulting in noise - induced hearing loss.

Nerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of CambrNerve cells damaged in diseases such as multiple sclerosis (MS), «talk» to stem cells in the same way that they communicate with other nerve cells, calling out for «first aid», according to new research from the University of Cambrnerve cells, calling out for «first aid», according to new research from the University of Cambridge.