An earlier study indicated that the intermediate step was likely a floppy loop area formed by proteins, which didn't seem compatible with the tough,
damaging fibril as an end result.
The final β - sheets bind together and stack up to form
the damaging fibrils.
Not exact matches
When myocilin goes wrong, or «misfolds,» it makes
fibrils that
damage tissue called the trabecular meshwork that normally allows the fluid inside the eye to drain and relieve interior pressure.
Such
fibrils form plaques, or areas of tissue
damage, that researchers can observe with microscopes.
Clumps that form from these disease proteins are composed of sticky
fibrils that
damage nerve cells.