Dosing was based on adult experience, but researchers found that the younger the child, the more quickly their bodies
eliminated daptomycin.
In their new study, the researchers looked for gene clusters associated with calcium - binding motifs similar to those in known antibiotics such
as daptomycin and friulimicin, which require calcium for their antimicrobial action.
The researchers showed that the malacidins work differently
from daptomycin and friulimicin, which kill bacteria by disrupting cell membranes and inhibiting cell wall biosynthesis, respectively.
One of the very limited treatment options is the
antibiotic daptomycin, yet 1 in 3 of all infections remains resistant to this treatment.
Oral in Enterococcus faecium LiaR Confer Increased Resistance to
Daptomycin through Alteration in LiaFSR Signaling» M. Davlieva, A. Tovar - Yanez, K. DeBruler, P. Leonard, M. Zianni, C. Arias and Y. Shamoo.
Antibiotic Resistance, Houston, TX, USA presentation «Adaptive Mutations in LiaR are Sufficient to
Confer Daptomycin Resistance in E. faecium by Inducing Phosphorylation - Independent Activation of the LiaFSR - mediated Membra...
The safety and efficacy of
daptomycin versus other antibiotics for skin and soft - tissue infections: a meta - analysis of randomised controlled trials
The vast majority of the antibiotics stocking our pharmacy shelves — from old standards like tetracycline to antibiotics of last resort like vancomycin and, most recently,
daptomycin — are derived from soil organisms.
Daptomycin is active against MRSA and was approved for use in adults in 2003 for treatment of skin and skin structure infections, and for bloodstream infections three years later.
«Drug combinations against Borrelia burgdorferi persisters in vitro: Eradication achieved by using
daptomycin, cefoperazone and doxycycline.»