Sensors provide total column water vapor
data over large regions and are not highly influenced by clouds.
Not exact matches
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a
larger than anticipated shift in payer mix to more highly discounted payer segments and geographic
regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products
over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy
data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
It must be as
large as those
regions of the brain from which it receives
data and
over which it exerts an influence.
That's because past measurements have been spotty and difficult to extrapolate across
larger regions, and the period
over which rainfall
data have been recorded is relatively short.
By looking at the
larger data sets, researchers working on this study could examine individual species and groups of species within a geographic
region, the temperature range inhabited by each species or species group, and the impact of temperature changes
over time.
Climate impacts research is in its infancy compared to science on the physical climate, for a number of reasons: attributing cause and effect isn't easy; neither is collecting
data over timescales and
regions long and
large enough such that it's possible to draw any meaningful trends from their analysis.
Lyn is the former Superintendent of Curriculum & Instruction Services in the York
Region District School Board, a
large Canadian school district, where she and her curriculum team analyzed assessment
data and developed a comprehensive literacy improvement program, which they launched with the cooperation of senior leadership, principals, and
over 9000 teachers.
Some
regions have few temperature measurement stations (e.g., the Sahara Desert) and interpolation must be made
over large,
data - sparse
regions.
The
larger decrease seen when ERA - Interim has complete coverage must be viewed with some caution, as the drying comes from areas for which HadISDH does not find suitable station
data and for a
region where ERA - Interim precipitation has a questionable decrease
over time.
For the
larger 50S — 90S
region a trend
over 1880 — 2015 can be calculated, at 0.03 °C / decade, if a minimum of 15 % of valid
data points is accepted.
Climate impacts research is in its infancy compared to science on the physical climate, for a number of reasons: attributing cause and effect isn't easy; neither is collecting
data over timescales and
regions long and
large enough such that it's possible to draw any meaningful trends from their analysis.
To date, most
large - scale water vapor climatological studies have relied primarily on analysis of radiosonde
data, which have good resolution in the lower troposphere in populated
regions but are of limited value at high altitude and are lacking
over remote oceanic
regions.
The issue, beyond the core
data representing but a single geospacial location and thus by itself not representative of the whole (and much
larger)
region in which it resides, is that the core is near the Greenland summit (in order to get the deepest profile of the ice possible) and therefore at an elevation of
over 2 miles above sea level.
«Here we present observational evidence... based on analyses of satellite
data for the period of 2003 - 2011
over a
region in west - central Texas, where four of the world's
largest wind farms are located».
These range from simple averaging of regional
data and scaling of the resulting series so that its mean and standard deviation match those of the observed record
over some period of overlap (Jones et al., 1998; Crowley and Lowery, 2000), to complex climate field reconstruction, where
large - scale modes of spatial climate variability are linked to patterns of variability in the proxy network via a multivariate transfer function that explicitly provides estimates of the spatio - temporal changes in past temperatures, and from which
large - scale average temperature changes are derived by averaging the climate estimates across the required
region (Mann et al., 1998; Rutherford et al., 2003, 2005).
While single - family home prices in the Bay Area dropped 2.5 percent from a year earlier, the worst performance among the 100
largest U.S. metropolitan areas, the capital
region posted a 10 percent increase
over the same period, according to Federal Housing Finance Agency
data.