Gabriela Cabral explains: «When a stem cell divides, it doesn't produce two identical
daughter cells as normal cells do.
Not exact matches
My
daughter is given privileges, such
as an allowance, a certain time to be home by, a
cell phone, and is allowed to have fun on the Internet, but she is also given guidelines to follow in order to enjoy these perks.
The main reason why people die of cancer is that the cancer
cells spread to form
daughter tumours, or metastases, in vital organs, such
as the lungs and liver.
In fact,
as with eukaryotic organisms, division of Caulobacter
cells generates two different
daughter cells, which can be easily separated.
«Having identified this important protein molecule in fruit flies, we can test whether the human version of the protein is important for stem
cells and their
daughters as well,» said Montell.
As a result, the
daughter cell does not inherit the defective proteins that burden the mother
cell.
This week, he and his colleagues report a potentially significant step toward that goal: a recipe that can turn human stem
cells into functional pancreatic β
cells — the
cells that are destroyed by the body's own immune system in type 1 diabetes patients such
as Melton's son and
daughter.
An asymmetric
cell division in non-stem
cells can instead result in two
daughter cells with very different fates, such
as one large
cell that reinitiates
cell division prematurely and a much smaller
cell that either grows very slowly or dies.
Although unequal division occurs among stem
cells — allowing one
daughter cell to remain a stem
cell while the other matures into another
cell type, such
as a skin or muscle
cell — the goal of a normal symmetric
cell division is to generate identical
daughter cells and increase
cell number.
The oncogene was coupled with a fluorescent marker so that
cells in which the oncogene was active could be easily identified, and
as these
cells proliferate, their «
daughter»
cells could also be tracked.
The researchers also found that another population known
as progenitor
cells — differentiated
daughter cells of stem
cells — started to behave like stem
cells: They began to live much longer than their usual lifespan of a few days, and they could also generate mini-intestines when grown outside of the body.
In contrast to mouse vRGs, which produce 10 to 100
daughter cells during brain development, a single human oRG can produce thousands of
daughter neurons,
as well
as glial
cells — non-neuronal brain
cells increasingly recognized
as being responsible for a broad array of maintenance functions in the brain.
The efficient compaction of DNA during cellular division ensures equal distribution of DNA into
daughter cells and prevents aneuploidy, which has been implicated
as a major driver of tumor development.
«In the transition from skin
cells to stem
cells, and then
as the stem
cells grew in culture and divided to produce their own
daughter stem
cells, the triplet repeat expansions within FXN became longer,» said Ku.
Daughters of the small intestinal stem
cells, the Paneth
cells, serve
as crypt niche
cells by providing Wnt, Notch and EGF signals (30).
Numerous biochemical and structural changes occur throughout the
cell as the microtubule - based spindle assembles and attaches to the condensed chromosomes, segregates them, and signals to the
cell cortex to induce cleavage into two
daughter cells through an actin - based contraction.
This division can be oriented,
daughter cells can be pushed inside or outside
as result of the mitotic spindle orientation, and asymmetric,
daughter cells can acquire distinct components giving them different contractile properties.
As a stem
cell divides, one
daughter cell, called a gonialblast, moves out of the niche in an orderly fashion to generate mature sperm
cells.
My
cell phone is an antique (
as per my
daughters!)