Sentences with phrase «deacetylase inhibitors»

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines.

For example, TGF - β and lovastatin target to the Sp1 - 3 site (17) whereas both of Sp1 - 3 and Sp1 - 4 sites are required for the action of the histone deacetylase inhibitor suberoylanilide hydroxamic acid (22).

Histone deacetylase inhibitors affect DNA structure and gene signaling.

OnKure is currently advancing the first Largazole - derived, histone deacetylase inhibitor into Phase 1 clinical trials.

Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, Li J, Castellano S, Sbardella G, Issa JP, Bedford MT (2011) Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.

Histone modifier gene mutations were associated with inferior progression - free survival time of the patients, irrespective of chemotherapy regimens, but an increased response to the histone deacetylase inhibitor chidamide.

The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo.

Reduction of graft - versus - host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.

Histone deacetylases inhibitors activate CIITA and MHC class II antigen expression in diffuse large B - cell lymphoma.

Suppression of KLF9 also induced resistance to another anti-myeloma agent, novel histone deacetylase inhibitor LBH589.

Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.

Some of these changes in gene expression can be reversed by pharmacological alterations of chromatin structure by the histone deacetylase inhibitor Trichostatin A (TSA) and the methyl donor L - methionine [19], [20].

The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down - regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.

These findings reveal a unique role for VPA as a histone deacetylase inhibitor in reducing the donor CD4 + T cells that contribute to GVHD, which may provide a strategy to reduce GVHD while preserving the GVL effect.

When the researchers administered drugs called histone deacetylase inhibitors (HDACs)-- which promote acetylation — to mice, they had the same effect as environmental stimulation.

A preclinical study in mice published by Cell Press January 16th in the journal Cell reveals that drugs known as histone deacetylase inhibitors (HDACis) can enhance the brain's ability to permanently replace old traumatic memories with new memories, opening promising avenues for the treatment of posttraumatic stress disorder (PTSD) and other anxiety disorders.

In their new paper, Reh and his colleagues show that, by using a drug that blocks epigenetic regulation called a histone deacetylase inhibitor, activation of Ascl1 allows the Müller glia in adult mice to differentiate into functioning interneurons.

«This means that patients who develop resistance to certain classes of chemotherapy can benefit from drugs that modulate histone marks such as histone deacetylase inhibitors, some of which are already approved by the Food and Drug Administration.

Therefore, DNMT inhibitors such as DAC and zebularine have been actively explored as cancer therapeutic agents, especially when they are used in combination with a histone deacetylase inhibitor, such as trichostatin A (15, 26, 32, 33, 34, 35, 36).

OSU - HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model.

Review Publication - Mechanisms of Histone Deacetylase Inhibitor - Regulated Gene Expression in Cancer Cells

20) and several chemical drugs including mitogen - activated protein kinase inhibitor and histone deacetylase inhibitor (21, 22).

Valproic acid (VPA) was described as a histone deacetylase inhibitor that had anti-inflammatory effects and reduced the production of proinflammatory cytokines in experimental autoimmune disease models.

Multiple classes of agent with distinct mechanisms of action are now available for the treatment of patients with relapsed and / or refractory multiple myeloma (RRMM), including immunomodulatory agents, proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies.

Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft - versus - host disease and preserves graft - versus - leukemia effect.

We and others have demonstrated that histone deacetylase inhibitors have neurotrophic effects in experimental models of PD.

Title of thesis: «Study of the pro-apoptotic effect of histones deacetylases inhibitors, used alone and concurrently with chemotherapeutic agents, on human lung cancer cells».

Suppression of oxidative stress by beta - hydroxybutyrate, an endogenous histone deacetylase inhibitor.

04:25 Ketones affect histone deacetylase inhibitors (HDACs).