Sentences with phrase «deacetylation by»
SIRT1 deacetylation by the NAD + salvage pathway may regulate the cellular redox system, the energetic process underlay ROS production.
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PARP family members are also NAD + - consuming enzymes which degrades NAD + in NAM and O - acetyl ADP ribose by sirtuin mediated deacetylation.
Through synthetic viability screening, we discovered that histone H4 K16 deacetylation drives the sensitivity of yeast cells to camptothecin and that inactivation of this pathway by mutating H4 K16 or the genes SIR1 - 4 suppresses much of the hypersensitivity of tof1 ∆ strains towards this agent.
Silencing of the Oct4 promoter in P19 cells is a complex process, mediated by a combination of events including orphan receptor binding, DNA methylation, histone deacetylation, and heterochromatin formation [36], [37].
Chitosan is naturally or synthetically produced by deacetylation of chitin (removing acetyl [COCH3] groups).
The increase in intracellular NAD elicited by CD38 deletion significantly activated SIRT1 and prompted clinical phenotypes similar to those expected for SIRT1 activation, including protection against diet - induced obesity and a robust deacetylation of SIRT1 targets.