Sentences with phrase «deactivated genes»

The researchers used valproic acid which can induce the activation of such deactivated genes in fungi.

At the molecular level, RNA can bind DNA to deactivate gene segments, bind other RNA or it can bind proteins, activating or deactivating them.

Last January, state - of - the - art computer aided modeling enabled the researchers to identify an anti-cancer agent capable of deactivating a gene known to be essential for the metastatic spread of breast cancer.

They processed data relating to genetics, including DNA sequences, and to gene expression, as well as epigenetic features — chemical reactions that influence genome functioning and hence phenotype by activating and deactivating genes.

Mice engineered to express Lin28 in their kidneys developed Wilms tumor, which regressed when Lin28 was withdrawn, indicating that strategies aimed at blocking or deactivating the gene hold therapeutic promise for children with Wilms.

«In order to be able to research more closely what effect PSENEN has, we, in collaboration with Prof. Odermatt, deactivated the gene in some zebrafish larvae and then compared these with normal larvae under the microscope,» explains Damian Ralser.

«When we modify the DNA of the worms and deactivate the gene for TRH, the worms stay smaller than their healthy counterparts.

The team then introduced short RNA molecules that deactivate a gene called Id1, which promotes angiogenesis and is active in endothelial progenitors.

In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cells.

He'll deactivate genes in the embryos to see what roles they play in early development.

Intensive breeding evidently deactivates the gene.

In intellectual disability, mutations will simply deactivate the gene.»

They also want to be able to insert more subtle mutations, such as those reported in HIV - resistant individuals, which could alter cell function just enough to confer resistance but without fully deactivating the gene and impeding cell function.

Genetic mutations that alter tumor suppressors such as the p53 gene are known to help tumors grow, and epigenetic modifications, too, can deactivate genes like this one.

When you're fasting your body uses fat as fuel and preserves muscle.Researchers from the National Institute of Aging theorized in 2003 that intermittent fasting helped trigger the SIRT1 gene, thought to both stimulate cells to release fat for use as an energy source and to deactivate the genes responsible for promoting fat storage.Other research conducted at the University of California at Berkeley indicate that this type of alternate day fasting can protect against diabetes and excessive weight gain.

The vegan diet managed to activate genes responsible for preventing diseases and deactivate genes which cause different health conditions such as prostate cancer, breast cancer, heart disease, and other diseases (read more >).

In a separate study presented at the Entomological Society of America conference in December in Indianapolis, Casteel found that high carbon dioxide conditions also deactivate genes that help soybean plants defend themselves indirectly by pumping out chemicals called «green leaf volatiles,» which lure natural enemies that kill insect pests.

Not exact matches

Deactivating the VHL gene makes animals react as if they're in a low - oxygen environment, also called hypoxia.

By binding onto these genes, Bcl6 deactivates the DNA, stopping genes from producing RNA and proteins.

In specific locations, genes with high methylation levels are deactivated.»

Therefore, they must explore the effects of deactivating it on the body's ability to fight infections and other diseases — as hampering the gene's effects only in red blood cells would be difficult.

When the gene is altered, the spellchecker is deactivated and mutations accumulate throughout the cell.

When their gene for the thyrotropin - releasing hormone (TRH) is deactivated, roundworms stay smaller than their healthy counterparts.

Moms could also evolve to imprint (deactivate) their copies of the genes that increase growth.

To infer the functional effects of these differences, they ran multiple computational analyses, including comparisons to massive databases of known gene functions and of mice in which genes are artificially deactivated.

Donn says: «The infected crop plants now carry the bacterial gene, which deactivates phosphinothricine.

This gene codes for another enzyme — phosphinothricine acetyl transferase, or PAT — which deactivates phosphinothricine.

These mutations deactivate the POT1 gene that protects the ends of our chromosomes from damage.

It seems that mutations that deactivate the POT1 gene may underlie other cancers, not just melanoma.

Various chemical modifications in the genome determine whether genes are read or deactivated.

To find out whether variants of FRO2 were actually causing the difference (rather than merely being associated with it), the team grew seeds whose FRO2 gene had been deactivated.

All plants in which the FRO2 gene had been deactivated now had stunted roots.

To find out what these genes do, and which ones are master regulators of development, researchers have several approaches, including deactivating embryonic genes in mice.

Acetylation — the addition of a small clump of atoms called an acetyl group — may be the most important body process you have never heard of: It activates and deactivates proteins, thereby regulating access to our DNA and helping control gene expression.

To better understand the origins of obesity and this associated syndrome, Dr. Verdin and his colleagues deactivated, or turned off, the SIRT3 gene in laboratory mice.

And, while the genetically - modified mice were made somewhat better by deactivating the HD gene in their hypothalamus, this approach isn't useable in human HD patients because their HD genes don't contain the sequences needed to turn them off with virus used by Petersen and colleagues.

«We could see what happened in the living fly after we deactivated or overexpressed a gene.»

However, getting the gene editing system into the human brain is still a big challenge, and so is the risk that it will snip in the wrong place before it deactivates itself.

«Until now, the only way to get similar information was to deactivate, or «knock out» specific genes within an enzyme and observe the impact,» explained Hannes Braberg, a graduate student in Dr. Krogan's lab and the paper's lead author.

The KamiCas9 genome editing system first deactivates the huntingtin gene, and then about four weeks later it shuts itself down

«But RNAPII is so critical that deactivating even one gene often kills the cell.

CRISPRi, first reported in 2013, relies on a deactivated version of the Cas9 protein, which — together with an inhibitor protein called KRAB — sits on a target gene.

That means it first deactivates the huntingtin gene, and then about four weeks later the genome editing system shuts down.

In both cell types, all genes are deactivated except the ones needed by a skin or liver cell to be a skin or liver cell, and to function appropriately.

New methods now allow researchers to sometimes directly show which genes have been activated or deactivated by the histones.

«Researchers take blood samples before and after yoga practice to see which genes have been turned on and which were deactivated,» says Khalsa.

This gene deactivates damaged cells in the heart.»

The result was that Xist modified the extra copy so as to deactivate most of its genes and the protein production associated with Down's.

They showed that under high carbon dioxide conditions, plants deactivate three genes that help them produce chemical defenses against insects.