CAR - T treatments, including competing products from Novartis rivals Kite Pharma and Juno Therapeutics, come with the risk of potentially
deadly side effects such as cytokine - release syndrome (CRS), in which a glut of T - cell - assisting cytokines can cause high fever, low blood pressure, and problems with lung oxygenation.
Not exact matches
Thus far,
such side effects seen in clinical trials have been minor, but it sometimes takes years of exposure to a drug before
deadly infections show up, he says.
Steven Pavletic, who heads the Graft - versus - Host and Autoimmunity Section at the National Cancer Institute in Bethesda, Maryland, says the standard treatments — corticosteroids
such as prednisone — «carpet bomb» the immune system, causing a host of
side effects and weakening the immune response to potentially
deadly infections.
And while a study of 200 to 300 arthritis patients is large enough to show whether a new drug relieves pain, just one
such study isn't large enough to pick up less - common — but potentially
deadly —
side effects.
Common treatments
such as anti-inflammatory drugs (ibuprofen or aspirin), or steroids like prednisone, though often useful for acute problems, interfere with the body's own immune response and lead inevitably to serious and
deadly side effects.