Sentences with phrase «deafness model»

In the recessive deafness model, gene therapy with TMC1 restored the ability of sensory hair cells to respond to sound — producing a measurable electrical current — and also restored activity in the auditory portion of the brainstem.

In the dominant deafness model, gene therapy with a related gene, TMC2, was successful at the cellular and brain level, and partially successful at restoring actual hearing in the startle test.

However, Holt's study also showed that gene therapy with TMC2 could compensate for loss of a functional TMC1 gene, restoring hearing in the recessive deafness model and partial hearing in the dominant deafness model.

Not exact matches

The researchers performed state - of - the - art next generation sequencing (NGS) on a model of human deafness to identify the critical lncRNAs.

So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

Otoferlin's size has precluded rescue experiments in which a modified mRNA for otoferlin is transfected into an animal model to replace a suppressed or knocked - down otoferlin gene causing deafness.

«NIH is committed to making knockout mouse models more widely accessible to the biomedical research community,» said James Battey, M.D., Ph.D., director of the National Institute on Deafness and Other Communication Disorders (NIDCD), who is also the co-chair of the Trans - NIH Mouse Initiative.

Hennebold is attempting to create these «knockout» models for human diseases like hereditary blindness and deafness, among other disorders.

Yet another primary interest is in the genetics of hearing and deafness disorders using mouse models of human deafness disorders and genome - wide association studies in age - related hearing impairment.

The U.S. Department of Transportation is committed to being a model employer of a diverse workforce that includes people with disabilities, especially those with targeted disabilities (blindness, deafness, partial and full paralysis, missing extremities, dwarfism, epilepsy, intellectual disabilities, and psychiatric disabilities).