Sentences with phrase «death by apoptosis»

Ionizing radiation is a potent DNA damaging agent that interacts with cellular DNA and induces lesions in the irradiated cells and prevents cell proliferation and induces cell death by apoptosis or necrosis depending on the radiation dose.

Not exact matches

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

Chemotherapy drugs are often designed to kill off malignant cells by damaging their DNA until they transition to a programmed death mode called apoptosis.

Rather, the group speculates that the transplanted cells secreted protective neurotrophins, proteins that promote cell survival by keeping neurons from inducing apoptosis (programmed cell death).

Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell - survival proteins (survivin, Mcl - 1, XIAP or cIAP2).

The drug, birinapant, sensitizes the CA125 - negative cells to the chemotherapy by restoring apoptosis, or programmed cell death, said Dr. Sanaz Memarzadeh, a senior author of the study and a UCLA gynecologic cancer surgeon.

But he believes that targeting cancers for destruction by necrosis and not by apoptosis, the other main pathway to cell death, holds great promise therapeutically.

«The cancer stem cells actively regrow and respond to the induced damage or apoptosis (cell death) caused by chemotherapy in between the different cycles, similar to how normal tissue stem cells respond to wound - induced damages.»

The experiments performed by postdoctoral researcher Dr Xu revealed that BET inhibitors principally act to kill cancer cells through the process of apoptosis, or programmed cell death.

Across multiple triple - negative breast cancer subtypes, inhibiting the androgen receptor greatly increased apoptosis (programmed cell death), inhibited growth and increased necrosis by 60 percent in animal models.

The mitochondrial pathway of cell death (apoptosis) starts by permeabilization of the mitochondrial outer membrane which becomes peppered with small holes.

By invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the celBy invigorating the mitochondria, SIRT3 and SIRT4 extend the life of cells, by preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the celby preventing flagging mitochondria from developing tiny holes (or pores) in their membranes that allow proteins that trigger apoptosis, or cell death, to seep out into the rest of the cell.

The other 1 million or so oocytes present at birth die off gradually by programmed cell death, or apoptosis, until a woman reaches menopause at mid-age.

They kill cells by releasing small cytoplasmic granules of proteins called perforin and granzyme that cause the target cell to die by apoptosis (programmed cell death).

Apoptosis (programmed cell death) at the tips of the villi - we lose grams of tissue every day in this way, which needs to be constantly replaced by the stem cells buried in the crypts

In this case, the trigger is a drug that interacts with the protein produced by the «suicide gene,» which metabolizes it into a form deadly to the cell, causing it to commit programmed cell death (apoptosis).

When BubR1H / H; INK - ATTAC mouse bone marrow cells were pushed into senescence in vitro by the PPAR - γ - activating drug rosiglitazone, a subpopulation of the cells exhibited high levels of INK - ATTAC expression and GFP, coupled with SAβ - gal staining; subsequent to treatment with the INK - ATTAC activating drug, these cells rapidly entered into apoptosis, and within 48 h were either destroyed or in the cell death process.

NK cells kill infected cells by releasing small cytoplasmic granules that trigger cell death (apoptosis).

In embryos where the mix of normal and abnormal cells was half and half, the researchers observed that the abnormal cells within the embryo were killed off by «apoptosis», or programmed - cell death, even when placental cells retained abnormalities.

AXL mediates resistance to TRAIL - induced cell death in esophageal adenocarcinoma (55); it remains to be determined whether ABL - mediated protection from TRAIL - induced apoptosis in breast cancer cells is mediated by AXL or other targets.

Given the apoptosome's critical role in the execution of stress - induced apoptosis, these studies provide key insights into the mechanisms by which many, if not most, chemotherapeutic agents induce cell death.

Gross brain pathology from infants with presumed or laboratory - confirmed ZIKV infection, primarily from neuroimaging, closely resembles neuropathology associated with congenital cytomegalovirus (CMV).48 The most notable difference is the distribution of intracranial calcifications (ie, typically subcortical in congenital ZIKV infection and periventricular in CMV).48, 49 Such calcifications are likely dystrophic and related to cell death, either by necrosis, apoptosis, or both.50

Since TNFα is such a potent inducer of apoptosis through TNFR1 death domain signaling, and amiodarone treatment results in the down regulation of TNFα with concomitant upregulation in TNFR2 signaling in NSC alone, it is possible that amiodarone selectively kills NSCs by lowering the threshold of TNFα required to trigger apoptosis in NSCs via upregulation of TNFR2 pathways in NSCs and not dopaminergic neurons.

The drugs reduce pain and inflammation by inhibiting the cyclooxygenase (COX) enzymes, which are involved not only with inflammation but also with certain processes involved in cancer, such as blood supply to the tumor and programmed cell death (known as apoptosis).

Studies indicate that lipid peroxides, which can cause free radicals, induce the cell death (apoptosis) of hair follicle cells in an inflammatory process which is gradual and initiated by several factors.

Chlorella has anticancer properties, preventing the growth of cancerous cells by inducing apoptosis, or cell death.

As if that were not challenge enough for a brain that is already struggling to metabolize fuel efficiently, AGEs themselves have been shown to be neurotoxic, likely by inducing apoptosis (cell death) and lipid peroxidation — a process that is especially damaging to cells whose membranes are particularly rich in PUFAs.10, 33

Prevention of cancer by encouraging the death of cancer cells, AKA apoptosis.

Estrogen does this by activating a gene known as Bcl - 2 that slows the process of cell death, known as apoptosis.

In cancer therapy, melatonin counteracts chemotherapy toxicity, by acting as an anti-oxidant agent, and promotes apoptosis (programmed cell death) of cancer cells, thus enhancing the toxicity of chemotherapy.

It can also kill many different types of cancer cells by triggering apoptosis (programmed cell death) without affecting normal cells.

This leads to β - cell damage, in part mediated by oxidant damage, that triggers apoptosis or programmed cell death.