The scientists describe that this protein triggers
the death of brain stem cells.
Not exact matches
When it reaches the
brain, Zika virus infects neuronal
stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early
death of these neuronal
cells.
«The bottom line question,» says Christopher Austin, a neurogeneticist at Merck Research Laboratories in West Point, Pennsylvania, is whether this kind
of gene therapy can
stem the rate
of brain cell death.
These results collectively suggest that neural
stem cells need MSI1 to generate enough neurons for normal
brain size, but the presence
of MSI1 also increases the vulnerability
of these
cells to Zika infection, leading to the
death of the population which ultimately results in microcephaly.
«The Vienna team
of Dr. Javier Martinez, also a co-corresponding author on the study, could actually show that mutations in CLP1 affect tRNA biogenesis and that CLP1 mutant
brain stem cells become more apoptotic (invoking
cell death).
Several tests in cultured
cells indicated that ganciclovir would cause the
death of HSV - TK - expressing
stem cells, and testing in the mouse model confirmed that administration
of the drug after successful treatment
of brain metastases successfully eliminated therapeutic
stem cells that also expressed HSV - TK.
In a study published in the journal
Cell Stem Cells, Maura Boldrini, from Columbia University, and colleagues studied the
brains from corpses
of people who were between 14 and 79 years old at the time
of their
death.
The Zika virus is known to negatively impact the growth
of fetal
brains and a group
of researchers publishing in the journal
Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferat
Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferat
Cell have investigated the effect
of Zika on the adult
brain reporting that infection can lead to
cell death and reduced proliferat
cell death and reduced proliferation.
Once in your
brain, your
stem cells are called upon to perform the important task
of improving blood flow to tissues, halting destructive inflammation and premature tissue
death, while ultimately replacing damaged
cells.