Sales plummeted to $ 1.2 billion in 2009, two years after a study was published in the New England Journal of Medicine (NEJM) that linked Avandia to a 43 percent increased risk of heart attack and a 64 percent higher risk of cardiovascular
death than patients treated with other methods.
By 2009, sales had dropped to $ 1.2 billion following a damning study published in the New England Journal of Medicine (NEJM) in 2007, which linked Avandia to a 43 percent increased risk of heart attack and a 64 percent higher risk of cardiovascular
death than patients treated with other methods.
In the era of personalized cancer therapy, patients with TNBC remain at considerably higher risk of relapse and
death than patients with other breast cancer subtypes, due to the aggressive nature of TNBC and the lack of newer targeted therapies for the disease.
Not exact matches
Because it makes up more
than 13 % of all new cancers and nearly 27 % of all cancer
deaths in the U.S. Just 17.7 % of diagnosed
patients are still alive five years out from their diagnosis.
ACADIA Pharmaceuticals Inc. (NASDAQ: ACAD) faded 24 percent Monday after CNN exposed the
deaths of more
than 700 Nuplazid
patients since the drug's June 2016 launch.
His research concluded that only those with a high risk of
death actually benefited from heart transplants, more
than 80 \ % of donor hearts going to
patients who were likely to live for longer without a transplant.
According to Professor Patrick Pullicino, far too often elderly
patients who could live longer are placed on the LCP which has now become, he says, an «assisted
death pathway» rather
than a «care pathway».
In an earlier book, Seduced by
Death: Doctors,
Patients, and the Dutch Cure (1996), Hendin described how the actual witnessing of the effects of legalized euthanasia, far more
than any theoretical consideration, persuaded him of its pernicious impact.
A disturbing article published in JAMA Internal Medicine propounded a «worse
than death» category to measure
patient suffering in the context of making treatment decisions for hospitalized
patients.
Should the «worse
than death» meme ever be accepted by society, or adopted into the standard - of - care guidelines established by healthcare technocrats, or implemented under Obamacare cost / benefit insurance coverage guidelines, then expanding access to assisted suicide to — and even rationing the healthcare of — such
patients is an imminent possibility.
From «States Worse
Than Death in Hospitalized
Patients»:
The authors asked hospitalized
patients to rate conditions — which they were not then experiencing — on a sliding scale, ranging from «worse
than death, neither better nor worse
than death, a little better
than death, somewhat better
than death, or much better
than death.»
Patients displayed considerable heterogeneity in their ratings of health states relative to death... but significant percentages of patients rated each evaluated state of serious functional debility as equal to or worse tha
Patients displayed considerable heterogeneity in their ratings of health states relative to
death... but significant percentages of
patients rated each evaluated state of serious functional debility as equal to or worse tha
patients rated each evaluated state of serious functional debility as equal to or worse
than death.
The essay «God as Monica's Breast» is worth the price of the volume, and the «Consenting to Die» essay, which discusses suicide and
death as something to do» rather
than just wait for, breaks into a fictional discussion between a doctor and a cancer
patient.
The fact that doctors are free to prescribe lethally for people with illnesses outside their areas of medical specialization — and to do so secure in the knowledge that they are legally less accountable
than if they were treating the same
patient — demonstrates the folly of legalizing doctor - prescribed
death.
If properly trained midwives exclude higher risk
patients in advance, then why is their
death rate acceptable only in a study that has much stricter criteria for inclusion
than real life?
Analyzing medical
death rate data over an eight - year period, John Hopkins
patient safety experts have calculated that more
than 250,000
deaths per year are due to medical error in the United States.
So even when homebirth midwives stick to low risk
patients, homebirth has a
death rate 320 % higher
than comparable risk hospital birth.
> So even when homebirth midwives stick to loss risk
patients, homebirth has a
death rate 320 % higher
than comparable risk hospital birth.
Armor spokeswoman Teresa Estefan said the company had treated more
than 200,000
patients at Nassau's jail, and «sadly, there are
deaths which are not preventable as is the case in some of the most prestigious hospitals.»
Similarly, Balboni wrote, the cancer
patients who relied on private, unspoken religious beliefs to manage their illness were «nearly three times more likely to receive intensive life - prolonging care near
death and less likely to enter hospice during the final weeks of life»
than those without a pronounced religious sense.
«Our research indicates that insertion of cervical pessary at around 22 weeks in both randomly selected women pregnant with twins and in
patients with a short cervix of less
than 25 millimeters does not reduce the rate of spontaneous early preterm birth, perinatal
death, adverse neonatal outcome, or need for neonatal therapy.»
Over a median follow - up of nearly eight years,
patients who were current smokers had a 40 % increased risk of cancer relapse, as well as more
than 2 - times increased risks of cancer spread and cancer - related
death, compared with
patients who were never smokers.
In addition, some
patient groups and members of Congress have recently asked why AIDS receives disproportionately far more
than diseases with higher
death rates, such as heart disease and Alzheimer's.
Patients undergoing surgery for a hip fracture were older and had more medical conditions than patients who underwent an elective total hip replacement, factors that may contribute to the higher risk of in - hospital death and major postoperative complications experienced by hip fracture surgery patients, according to a study in the September 15 issue
Patients undergoing surgery for a hip fracture were older and had more medical conditions
than patients who underwent an elective total hip replacement, factors that may contribute to the higher risk of in - hospital death and major postoperative complications experienced by hip fracture surgery patients, according to a study in the September 15 issue
patients who underwent an elective total hip replacement, factors that may contribute to the higher risk of in - hospital
death and major postoperative complications experienced by hip fracture surgery
patients, according to a study in the September 15 issue
patients, according to a study in the September 15 issue of JAMA.
«The increased
death rate is cause for concern, because the prognosis for this tumour is bleak, with less
than five percent of pancreatic cancer
patients surviving for five years after diagnosis.
Each year in the U.S., nearly 46,000 people are diagnosed with pancreatic cancer, and more
than 39,000
patients die, making it the fourth leading cause of cancer
death.
Patients with 2 or 3 of the predictors had a sudden cardiac death risk that was 145 times greater than patients with normal levels on all 3 m
Patients with 2 or 3 of the predictors had a sudden cardiac
death risk that was 145 times greater
than patients with normal levels on all 3 m
patients with normal levels on all 3 measures.
More unexpected, researchers at the University of Wisconsin at Madison uncovered a link between sleep apnea and cancer mortality: Cancer
deaths among
patients with severe apnea were five times higher
than among those without.
However, in the largest study of its kind so far, scientists from the German Cancer Research Center (DKFZ) in Heidelberg have now shown that the risk of
death from heart disease in breast cancer
patients following radiotherapy or chemotherapy is no higher
than it is among the average population.
During the following season (2013 - 2014), when H1N1 viruses dominated and the standard - dose vaccine had better effectiveness
than the previous season, the high - dose vaccine was not significantly better at preventing
deaths among the Medicare
patients studied.
The primary endpoint of
death and non-fatal heart attack at 30 days was no different between the two groups (7 percent in the aspirin group and 7.1 percent in the placebo group); however, major bleeding was significantly higher in aspirin - treated
patients than in the placebo group (4.6 percent vs. 3.7 percent).
For each 1 degree C increase in the body temperature of a stroke
patient, the risk of
death or severe disability more
than doubles.
Furthermore, this frailty test was shown to be a more reliable predictor of
death and serious complications
than patient age.
«And yet more
than six of every 10 black trauma
patients are served each year in high - mortality hospitals, which increases their risk of
death.
In a study presented at the Society for Maternal - Fetal Medicine's annual meeting, The Pregnancy Meeting ™, in New Orleans, researchers will report that
patients delivered at home by midwives had a roughly four times higher risk of neonatal
deaths than babies delivered in the hospital by midwives.
Maintaining or achieving blood pressure control in
patients with arthritis and concomitant hypertension (treated or untreated) could avoid more
than 70,000
deaths from stroke and 60,000
deaths from coronary heart disease each year, 2 making it important to investigate the effects of various NSAIDs on blood pressure.
«Our study is the first to focus on weight change around RA diagnosis and risk of
death, rather
than weight change in
patients who had RA for many years, as in previous studies,» said Dr. Sparks.
Although some research has suggested that the use of the anticoagulant warfarin for atrial fibrillation among
patients with chronic kidney disease would increase the risk of
death or stroke, a study that included more
than 24,000
patients found a lower l - year risk of the combined outcomes of
death, heart attack or stroke without a higher risk of bleeding, according to a study in the March 5 issue of JAMA.
Newer drug - coated stents that keep arteries open have similar long - term rates of
death compared with traditional bypass surgery for
patients with more
than one diseased coronary artery.
Serious consequences, such as a reaction that threatened a
patient's life or caused a disability, were 2.6 times more frequent in 2005
than in 1998, while
deaths increased by 2.7 times, from 5519 in 1998 to 15,107 in 2005, say researchers who examined data collected by the US Food and Drug Administration (FDA).
The second question is more difficult to answer
than it might seem because the low prevalence of cancer and diabetes in Laron
patients is counterbalanced by an abnormally high risk of
death from other causes, especially accidents, alcohol, and convulsive disorders.
Patients will however be more concerned to avoid
death and major complications, such as heart attack or stroke,
than re-operations.
«To put the risks in perspective, if 100
patients had a partial knee rather
than a total knee replacement there would be one fewer
death and three more re-operations in the first four years after surgery.»
Death rates were 3.7 times higher in women who had a heart attack (8.8 per 1,000 person - years) and 1.8 times higher in women who had ischemic stroke (4.4 per 1,000 person - years)
than the comparison
patients (2.4 per 1,000 person - years), the authors report.
Data revealed today at The International Liver Congress ™ 2015 show that the long - term use of entecavir (ETV) or tenofovir (TDF) results in excellent 5 - year survival for Caucasian
patients with chronic hepatitis B (CHB), with more
than 95 % of
patients surviving at 5 years and a significant proportion of
deaths coming from liver - unrelated causes.
The fungal infection cryptococcal meningitis is responsible for more
than 180,000
deaths per year worldwide, mainly in HIV - infected
patients.
That's more
than 5 times the risk of
death seen in the
patients who had no additional non-fatal cardiovascular event while in the study.
Over the past decade,
death rates for black
patients were approximately 40 % higher
than white
patients.
Also, septic
patients with evidence of cytomegalovirus in plasma, a component of blood, had significantly higher 90 - day
death rates
than septic
patients who tested negative for the virus, although it is not clear whether the cytomegalovirus contributed to the additional
deaths.