Using a technique called nuclear magnetic resonance spectroscopy, the researchers measured the concentrations of 21 metabolites key to nerve function in the brains of 10
deceased schizophrenia patients and 12 normal human controls.
A team led by geneticist Steven McCarroll of the Broad Institute, based in Cambridge, Mass., combed through genetic information from about 29,000
schizophrenia cases, 36,000 controls and 700 brain samples from
deceased patients.