Not exact matches
After
deciphering the crystal structure of the catalytic domain of PHA synthase, in addition to other structural studies on whole enzyme and related proteins, the research team also performed experiments to elucidate the
mechanisms of the enzyme
reaction, validating detailed structures, enzyme engineering, and also N - terminal domain studies among others.
Richard H. Scheller (Genentech) and Thomas C. Südhof (Stanford University School of Medicine) identified and isolated many of this
reaction's key elements, unraveled central aspects of its fundamental
mechanism, and
deciphered how cells govern it with extreme precision.
To cite a few instances, polymerase chain
reaction (PCR), a molecular method developed over three decades ago, has been widely applied in disease diagnosis, disease
mechanism deciphering, and prognosis prediction; the elucidation of tyrosine kinase activity in cancer cells has led to the development of novel drugs for cancer treatment; and the identification of proteins and genetic molecules by molecular methods as biomarkers for disease diagnosis and prognosis has been drawing great interest.