Sentences with phrase «declined as amyloid»
Furthermore, in brains from APP transgenic mice conformation - specific antibodies have revealed the early appearance of intraneuronal fibrillar and oligomeric Aβ immunoreactivity, which declined as amyloid plaques appeared, and further became evident in the extracellular space [10].
https://actaneurocomms.biomedcentral.com/ Not exact matches
«Lumpy amyloid - beta, the stuff we see, ironically doesn't correlate as well as with cognitive decline the soluble amyloid,» Mitchell said.
Mitchell's latest findings have corroborated the prior study's findings on amyloid, and also added p - tau as a key suspect in cognitive decline.
«The correlation with amyloid plaque was there but very weak; not nearly as strong as the correlation between p - tau and cognitive decline.»
Also, Alzheimer's diagnosticians might be wise to their adopt cancer colleagues» early detection stance, she said, as Alzheimer's disease appears to start long before amyloid - beta plaque appears and cognitive decline sets in.
Other theories and lines of research have begun to prosper due to the lack of tangible human results for anti-amyloid immunotherapies, in particular that neurofibrillary tangles of misfolded tau protein are just as much a target for clearance as is amyloid - β, and that perhaps it is time to focus on the decline of known clearance mechanisms rather than the amyloid itself.
Identifying the molecular triggers for the onset of AD - related cognitive decline presently requires the use of suitable animal models, such as the 3xTg - AD mice, which develop both amyloid and tangle pathology.
These include insoluble extracellular plaques made of beta - amyloid peptide (Aβ); intracellular neurofibrillary tangles (NFTs) resulting from the hyperphosphorylation of tau (a microtubule - associated protein); loss of hippocampal neurons; a decrease in production of brain acetylcholine; and a marked decline in glucose usage in regions of the brain associated with memory and learning.5,11,20 - 22 All of these changes can be logically explained as the sequelae resulting from long - term dysregulation of insulin signaling and glucose metabolism.