Sentences with phrase «declines over time with»

«RNAi is very promising as a therapy, but the efficacy of the treatment declines over time with each new cell division,» Jose said.

Not exact matches

Any increase in TFWs in Southwestern Ontario should be seen as a surprise, as the labour market has been in decline in the region over the last decade, with London, Windsor and Hamilton experiencing significant declines in their full - time employment rates:

«We're in a very positive situation economically, with more Canadians working, with a strong level of growth, and we'll continue to have an approach to fiscal conservatism that shows a declining debt - to - GDP over time,» said Morneau.

The good news is that with companies like Google (goog) and Amazon (amzn) phasing out support for the media player in favor of newer technologies like the HTML5 coding language, attacks will likely decline over time.

Women with regular exposure to cleaning products may face a steeper decline in lung function over time, according to an international study.

But over time, traditional pensions are declining, and more of us are retiring with 401 (k) s, IRAs and our personal savings.

Today, with dividends reinvested, the value of each share has increased several times over despite the dot - com meltdown, the war on terror, higher national debt, and a declining dollar.

The Bureau of Labor Statistics reported earlier this month that food - at - home prices fell 0.1 % in November, the seventh straight month they've declined, and over the past 12 months, they're down 2.2 % from the same time last year with meats, poultry, fish, and eggs posting the biggest drops and now sitting 6 % below the year - ago figure.

As always, the challenge is to combine the right degree of flexibility in approach with sufficient confidence that the inflation rate will be on a declining path over time as to keep expectations anchored.

At a time like this, where many life insurers, particularly ones facing credit risks, and those having variable policies, where profitability has declined along with the stock market, the surcharges could have kicked additional life insurers over the edge, and who knows how big the cascade would have been.

«A short, sharp break off of all - time highs is never how bear markets begin» adding they tend to fall by 2 to 3 percent a month over their entire duration, with most of the decline coming in the last 40 percent.

While we believe lower commodity prices are a boon to the economy over time, the abruptness of their price decline and a lingering «commodity super-cycle» mentality likely caught many with more commodity inventory (acquired at higher prices) than proved desirable.

Because we're neither wise enough nor foolish enough to know in advance how much of our clients» initial spending is «core» (increasing with inflation) and how much is «discretionary» (declining over time), this is what we do at Cornerstone (see my February 2013 Journal column, «When an Ounce of Discretion (ary) is Worth a Pound of Core»).

It would just bring a major impact say if half the Americans were gay over a long period of time, sure it might solve a few problems with the decline from the billions, but in the end it... you should join speech & debate my friend, just my opinion they shouldn't allow gay marriage, they can have their relationships all they want, just my belief about it, I respect your beliefs as long as you respect mine.

These new members — hundreds of them over several years — have arrested a multi-year decline in the SELK, with the church body growing in 2015 for the first time in years.

It certainly doesn't help that with the current manager we seem to have declined to a point (I'm not talking recently because obviously we've had a few good results, but I'm talking over longer periods of time) where we don't seem to have a specific style of play.

It's certainly led to their decline its eighth place at the table, and with very little point advantage over the teams which are behind them, so theoretically it could happen after this round for the first time in the season they move to lower part of league table.

However, over time the gradual erosion of this bond of solidarity, combined with economic decline, undermined the willingness of states and host populations to welcome their neighbours.

For the first time, more English people than Scots back Alex Salmond's move to break up Britain — 25 per cent compared with 23 per cent — and while support for the policy has been declining over the years north of the Border, the opposite is true in England.»

Declines in VA acuity over time were associated with increased mortality risk in part because of decreasing levels of IADL over time.

In both cases the instrument showed changes in chlorophyll fluorescence that corresponded with declining plant health over time.

And the uniqueness of baby names has risen for both boys and girls since the 1880s, with the percentage of children receiving one of the 20 most popular names declining over time.

So with these little bits of conduct, then, you can actually chart a decline in deference to the president over time and the rise of a more vigorous, aggressive way of dealing with public figures.

Elderly men with low levels of testosterone or other sex hormones have twice the likelihood of having declining physical function over two years» time compared with their peers who have the highest hormone levels, a new study from Australia finds.

The HIV - specific IgG3 response correlated with decreased infection risk, but the effect waned over time, similar to the declining efficacy observed in the RV144 trial.

Although most patients do not go into long remissions and may even decline over time, some 20 to 30 percent of this majority experience only moderate symptoms that interfere with — but do not devastate — their ability to perform in the workplace or maintain friendships.

Dr Josephine Mollon from King's IoPPN, now with Yale University, said: «For individuals with psychotic disorders, cognitive decline does not just begin in adulthood, when individuals start to experience symptoms such as hallucinations and delusions, but rather many years prior — when difficulties with intellectual tasks first emerge — and worsen over time.

Post-transplant, patients with diabetes experienced a significant decline in major fatal / nonfatal cardiac events and deaths from infections over time.

«We observed higher rates of neurocognitive decline, increased symptom burden and a decline in health - related quality of life over time among non-progressing patients treated with bevacizumab,» he says.

Our findings suggest that people with neighborhoods that require more mental complexity actually experience less decline in their mental functioning over time.»

Compared with men with sodium levels of 141 - 142 mmol / L, men with levels of 126 - 140 mmol / L were 30 % more likely to have cognitive impairment at baseline and 37 % more likely to experience cognitive decline over time.

The investigators also found an association of high serum sodium (143 - 153 mmol / L) with cognitive decline over time.

I guess I am surprised that with better understanding of the importance of water vapor feedback, sulfate aerosols, black carbon aerosols, more rapid than expected declines in sea ice and attendant decreases in albedo, effects of the deposition of soot and dust on snow and ice decreasing albedo, and a recognition of the importance of GHGs that were probably not considered 30 years ago, that the sensitivity has changed so little over time.

In recent years, the age when women have their first child has slowly increased, with the BFS highlighting how female fertility starts to decline from the late 20s as the number of eggs that women naturally have are progressively lost over time.

For significant periods of time, the reconstructed large - scale changes in the North Pacific SLP field described here and by construction the long - term decline in Hawaiian winter rainfall are broadly consistent with long - term changes in tropical Pacific sea surface temperature (SST) based on ENSO reconstructions documented in several other studies, particularly over the last two centuries.

And the pace at which these declines have occurred has accelerated over time, the CDC noted, with the greatest improvements seen since 2008.

Researchers have found the risk of dementia was higher in older women with weak circadian rhythms, and tracking circadian rhythms over time has been shown to predict cognitive decline in older adults.

With declining collagen levels in the dermis, our skin becomes visibly less firm and develops more lines, wrinkles and sagginess over time.

They can be «mopped up» by anti-oxidants and mitochondria usually contain anti-oxidants that do this but these may decline in number, over time and with age.

Natural changes in muscle, bone, lung tissue, and nervous system function over time causes a persons lung capacity to decline with age.

Hey Doc I started training at the age of 13 and literally never stopped ever I have had major knee surgeries 5 or so years ago I have had countless stressful jobs I could not stand I finally said enough is enough and pursued by Personal training career I have an unbelievable passion for the fitness / nutrition lifestyle I'm 26 now at the age of 22 - 23 I achieved body fat percentage of 2 percent while working a back breaking job and literally sleeping 2 - 3 hours a night due to my hormone imbalance I didn't have a spoil meal in 8 months I was finally achieving the look I've been longing for for the 10 years I was already training and it was due to proper training times and nutrition little did i know I was already deep in a over trained zone for years before that I used to spend 3 - 5 hours a day in the gym from the age of 14 through 19 years old i just loved it so much and though more was better as I got older I got smarter I studied non stop this all leads to my decline at age 23 I look back and I know every little thing I did wrong basically al all started at work 3 years ago to make a very long story short I had continued dizziness lack of sex drive for years insomnia all of the above to the 10th degree I know I've abused my body not many can say they have done the work i have done in gyms over all these years I left work one night with sharp pains in my abdomen got blood work done got called back a week or so later and was notified in A very unprofessional way that at the age of 23 I had a testosterone level of 73.6 I have all the blood work to prove it from then on I was treated horribly by doctors none believing what I havenput myself through in the prior years basically going into every appointment and teaching each person endos euros physicians etc..

Vegetables shredded finely showed a marked decline of glucosinolate level with post-shredding dwell time — up to 75 % over 6 hours

For example, Krueger (1998) uses data from the NAEP and documents test score increases over time, with large improvements for disadvantaged children from poor urban areas; the Current Population Survey shows declining dropout rates since 1975 for those from the lowest income quartile (Digest of Education Statistics, NCES 2012).

Even in jurisdictions with few restrictions on new starts, the numbers tend to decline over time.

However, some education experts and community leaders are questioning if Kayser's plan is necessary or even realistic for a school district with declining enrollment and a host of other problems that might take precedence over re-hiring, such as giving struggling students more instructional time and paying teachers for extra days.

Eighth - grade science results have been more mixed over time with stronger gains between the 1995 and 2003 administrations, followed by a slight decline.

This is why, if you closely watch any Internet business» BBB ranking, it often slowly declines over time since the number of customers being calculated by the BBB stays constant (because they don't update their records as quickly as Internet businesses acquire more customers), while the number of complaints rises statistically in accordance with the actual number of customers.

Over the course of this Scandalous Highlanders book series, I've done a lot of research on what was going on in the Highlands at the time of the English Regency — the easing of the restrictions placed on the Scots after their loss at the Battle of Culloden, the Clearances that were forcing landowners to replace tenants with Cheviot sheep, the decline of the clan system, etc..

When seen in an overall context wherein this ratio moves strongly in favor of print editions as sales numbers decline out the long tail, this model seems generally consistent with Amazon's recent (and, at the time, stunning) announcement that, looking back over an unspecified historic period, Kindle editions sales had accounted for somewhere between 26 and 35 per cent of all sales when both print and Kindle editions were available.

That long term trend is what will provide us with significant increases in wealth over time - Not attempting to buy and sell around periodic 5 % declines in the market (No one has yet appeared with the ability to consistently do that, and I will not be the first.)