Sentences with phrase «decrease over levels»

Not exact matches

There has been a fairly sustained increase in job creation over at least the last five months, Desjardins said, and the level of initial jobless claims has been decreasing.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Although that is an increase of 250,000 bpd over the 3rd quarter, it represents a 530,000 bpd decrease compared with the second quarter, the highest level of over-supply since the price collapse began in mid-2014.

The expectations component of the survey generally remained stable as well, although the average likelihood of applying for all types of credit over the next 12 months decreased slightly from their June levels.

The employment index climbed to 15.9 from 15.3, the part - time employment index decreased to 3.7 from 5.1, the hours worked index dipped to 8.0 from 8.3, the wages and benefits index grew to 23.5 from 20.9, the input prices index fell to 27.9 from 29.2, the selling prices index increased to 19.2, its highest level in over 10 years, from 17.0, the capital expenditures index slid to 16.0 from 17.6, the general business activity index rose to 14.5 from 13.4.

We recommend level term life insurance over decreasing term life insurance.

Perceptually, households have decreased their direct ownership of Treasuries as yield levels have fallen over the decades.

As the names imply, decreasing term policies pay a lower death benefit over time, while level term policies maintain the same death benefit for the term of the coverage.

They use a conventional glide path, which gradually decreases the allocation to equities with age to a constant after retirement, to determine target risk levels over the life cycle.

A decreased glycemic response means your blood glucose levels are raised more slowly so your body will feed you energy over a longer period of time.

Finally, we have reviewed a large - scale study on high blood pressure showing an association between high levels of protein intake (in the vicinity of 100 grams per day) and significantly decreased risk of high blood pressure over an 11 - year period of time.

Brazil Segment revenue was negatively impacted by a decrease in bran processing levels as well as a 12 % quarter over quarter decline in the average Brazilian Real versus US Dollar exchange rate.

While our player are currently increasing their fitness levels in the heat of Texas, something else has drastically decreased over the last couple of...

While some symptoms of blues will decrease over time once hormone levels are regulated, other women find themselves engulfed in a larger scale depression and may require medication to help them during this time.

Usually, the amount of milk required in the lactation aid increases over 1 to 2 weeks, then levels out for a variable period of time before decreasing.

[69] Research suggests that the antioxidant activity in expressed breast milk decreases over time, but remains at higher levels than in infant formula.

When a breastfeeding mother smokes, the nicotine levels in her blood and milk increase, and then decrease over time.

Sugar, fat, and calories increase in transitional milk over time and protein and antibodies decrease until mature milk levels are reached.

«The state board currently addresses its responsibilities with both a budget and a staffing level that has decreased or been flat over the past six budget cycles,» he said.

While the general mood in the room was one of cautious optimism about the Republican - led legislature's willingness to fund arts and culture at the recommended levels, there remained a possibility that the majority's professed desire for a tax decrease might eat away at the sector's hard - won gains over the past few years.

Using the Great Barrier Reef as their study case, they estimated the evolution of the region over the last 14,000 years and showed that (1) high sediment loads from catchments erosion prevented coral growth during the early phase of sea level rise and favoured deep offshore sediment deposition; (2) how the fine balance between climate, sea level, and margin physiography enabled coral reefs to thrive under limited shelf sedimentation rates at 6,000 years before present; and, (3) how over the last 3,000 years, the decrease of accommodation space led to the lateral extension of coral reefs consistent with available observational data.

According to figures from the World Bank, the Chinese economy's carbon intensity — the amount of CO2 emissions relative to the size of economic output — has decreased by almost 70 per cent over the past three decades (see «Peak planet: Carbon dioxide intensity «-RRB-, and a further 20 per cent reduction from current levels is promised by 2020.

In fact, you should have observed the amount of foam quickly decrease over time, and probably saw the bottom level of the foam quickly rise to a higher level.

Declines in VA acuity over time were associated with increased mortality risk in part because of decreasing levels of IADL over time.

«Physical activity decreases over time at all levels of COPD severity, leading to further decline.»

Physical activity decreases substantially over time in patients with chronic obstructive pulmonary disease (COPD) at all levels of severity, according to a new study from researchers in Germany.

Though levels of these flame retardants are decreasing over time, investigators found PBDEs in every child blood sample.

Over the past 200,000 years, replacement - level fertility rates have ranged from 2.1 to 3.0 children per couple, he said, noting that global population remained remarkably stable until the beginning of the 19th century, when decreased mortality in newborns resulted in fertility rates exceeding replacement levels.

For example, the model predicts that production of carbon dioxide must increase with time, a finding that goes against the conventional wisdom that carbon fluxes and atmospheric carbon dioxide levels have steadily decreased over the last 4 billion years.

When the water level decreases or stays static, fish production declines over time.

When residents of São Paulo chose gasoline over ethanol to fuel their vehicles, levels of ozone actually decreased, according to a Northwestern study.

Recently, Steffen's research has revealed some good news - levels of airborne mercury measured in Alert decreased between 1995 and 2007, possibly due to lower emissions from North America and Europe over that period.

Rising levels of education among US adults over the past 25 years may also have contributed to decreased dementia risk.

Red and orange colours indicate increasing ozone levels and blue colours indicate decreasing ozone levels over time.

The colour scale for increasing and decreasing ozone levels over time and associated p - values is the same as in Figure 8.

While the nutritional quality of our food and our activity levels have both decreased over time, our bodies may still behave like those of our ancestors.

The mean sea level referenced to these height systems has been decreasing over the past decades.

This dramatic increase in temperature occurs rapidly over 5,000 to 7,000 years as glacial sheets begin to decrease in size, sea levels rise and greenhouse gases increase.

Research published in the medical journal Circulation showed that among approximately 5,000 people over a period of 15 years, those who took higher levels of magnesium had a decreased risk of metabolic syndrome.

And University of Pittsburgh researchers discovered that women who reported feeling high levels of stress over the course of 20 years had decreased volume in the right side of the hippocampus.

A study published in the journal Sleep Medicine found that leptin levels decreased by 18 per cent and ghrelin levels increased by 28 per cent when sleep was restricted to four hours per night over two nights.

What's more, the American Heart Association has concluded that a short walk in the park can decrease the risk of getting high blood pressure, increased cholesterol levels and can prevent the likelihood of developing diabetes if done consistently over time.

«We were happy to see that for most kids, the levels of victimization were lower overall or decreasing over time.

Your body always tries to maintain a balanced state, also known as homeostasis, and while you're on a fat - loss diet and trying to maintain a caloric deficit over prolonged periods, leptin levels start to decrease as your body's survival mechanism in order to preserve fat and keep you from starving to death.

After the elimination phase, you'll slowly bring foods back in over a few weeks while looking out for any flare - ups of symptoms or a decrease in your energy levels.

MMSE scores decreased on average by 5 points in cognitively impaired individuals who didn't engage in an adequate level of physical activity over 5 years, in comparison to a decrease of only 1 point in individuals who met the required physical activity.

After 60 days, I slowly brought foods back in over a few weeks, looking out for any flare - ups of my symptoms or a decrease in my energy level.

Reducing IGF - 1 levels has a direct on decreasing insulin which may reduce tumor growth and cancer over time by following a ketogenic diet.

As men age, their GH levels will slowly decrease over time, as opposed to a woman's hormones which will usually plummet quickly during menopause.

Many studies have shown the decrease of LDL levels over time eliminates aliments such as Type2 Diabetes.