DBP has been associated with increased allergic symptoms and
decreased airway function.
Not exact matches
The most recent study report described in these same regions
decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a
decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine
decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic
functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper
airway patency.
Cook - Mills had done previous allergy research in mice showing alpha - tocopherol
decreased lung inflammation, protecting healthy lung
function and gamma - tocopherol increased lung inflammation and
airway hyperresponsiveness, a characteristic of asthma.
It also
decreased airway hyper - responsiveness to allergen, reduced lung inflammation and improved lung
function in mice sensitized to house dust mite allergens.
One of the major parameters was the safety of these agents in the respiratory
airways and lung parenchyma, since several of these agents are known to cause adverse effects.23 The main adverse effects observed were cough, transient fever and transient
decrease in the respiratory
functions after the aerosol administration.8, 19, 20 Moreover; it has been observed that excessive deposition of these agents in one site of the respiratory system can induce non-specific side effects in the form of pulmonary edema as observed with many other drugs.16 These side effects were milder when a premedication with bronchodilators and inhaled corticosteroids were administered.8, 19, 20 Until now no long term trial (> 9 months) has been performed since all patients included in previous studies had stage IV non-small cell lung cancer (NSCLC).