Sentences with phrase «decreased cell proliferation»

Furthermore, in animal studies, changes associated with retareded tumorgenesis, such as decreased cell proliferation rates in various cell lines and decreased incidence of lymphoma, have been observed.

Immunoblots showed almost complete inhibition of mTOR expression (as shown in Fig. 4B) that resulted in decreased cell proliferation as assessed by MTS assay (A).

Not exact matches

This means that the tumour becomes smaller as cell proliferation decreases.

«That depleted all sources of glutamine for the cells, and we found that cell proliferation decreased significantly,» Yang said.

In fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cells.

We have observed on several occasions that, for the majority of endothelial cell lines, the transfer to 37 °C conditions for 72 h correlated with a 50 % reduction in cell proliferation, a value that continued to decrease with time.

Lipton and colleagues now report that the p38 MAPK pathway is also the mechanism underlying decreased stem cell proliferation in the brain associated with HIV / AIDS.

Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro.

Moreover; in this study when siRNA was used to knockdown SPRINGTLY, a decrease in cell proliferation, invasion and increase in pro-apoptotic signals was detected [48].

This alteration likely can be attributed to a combination of decreased persistence of memory T cells (41) and enhanced homeostatic proliferation resulting from increased strength of signal downstream of the TCR (16).

Overexpression of Cox - 2 in Human Osteosarcoma Cells Decreases Proliferation and Increases Apoptosis

In addition to revealing details on how the tribbles protein may hamper insulin secretion, the study suggested ways in which it may increase beta cell death and decrease beta cell proliferation.

Therefore, we expected that PyMT - driven mammary tumours in Slc6a14 − / − mice would exhibit a decrease in cell proliferation, mTOR signalling and HIF1α.

A biomarker used to measure cell proliferation found a decrease in the activation of CD4 + T cells in the colon of the monkeys given both ARVs and probiotics while a cytokine test found the «overall functionality» of the CD4 + T cells in the colon of the probiotic arm had improved.

Tumor hypoxia is often linked to decreased survival in patients with breast cancer and has been shown to induce specific molecular changes in cells including changes that confer a more malignant phenotype such as increased proliferation (3), survival (4), invasion (5), and metastasis (6).

We also demonstrate that ACTB haploinsufficiency leads to reduced cell proliferation, altered expression of cell - cycle genes, and decreased amounts of nuclear, but not cytoplasmic, β - actin.

IL7R is expressed in HCC but not in normal liver cells, and can activate JAK2 to increase cell growth.57 SOCS3 is a negative regulator of the JAK / STAT signalling pathway, and can inhibit JAK2 itself.58 Therefore, inhibition of JAK2 by SOCS3 could result in decreased proliferation.

Significant drop in PSA levels (which is a biomarker of prostate cell growth); a drop in cholesterol (which is what we'd expect with a lower - fat diet, and all that extra fiber); and, importantly, a significant decrease in the cellular proliferation rate.

Rats on alternate - day fasting diets showed decreased levels of IGF - 1 and proliferation rates of T - cells and prostate cells (30).

Consequently, the normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals described by Winick and Rosso (18).

«the normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals.

Here is a quote from the discussion where Campbell describes the fatty liver and likens the decrease in cell proliferation to the retardation of brain growth that occurs in malnourished animals:

«[T] he normal rate of cell proliferation would have been decreased during protein deprivation, which is similar to the retardation of brain cell growth of young malnourished animals.

But even more significant, estradiol increased cell proliferation by 230 percent, whereas progesterone decreased it by more than 400 percent.

With this statistical division, there was a significant decrease in cell proliferation as a result of the fiber supplementation in six of the eight patients with initially high labeling indices and three of the eight patients with initially low indices, which suggests that wheat - bran fiber is protective against colon cancer.

In the model estrogen - independent breast cancer, lunasin and aspirin administration inhibits cell proliferation, arrest cell cycle in S - phase as well as a decreases expression of cancer genes.