Sentences with phrase «decreased expression for»

They found decreased expression for almost all of the genes of cholesterol synthesis, including a gene called SREBP - 2, which acts as a master regulator for cholesterol production.

Not exact matches

One should not in this connection let himself be deceived by the observation that the abstract thinking of the Greeks made it possible for them to understand in its purity the essence of the spiritual, and that therefore mythological, anthropomorphic ideas of God were abandoned by the Greeks, while in Judaism naïve mythological and anthropomorphic expressions about God, although they decrease, do not by any means disappear.

If you have been expressing for fifteen minutes, decrease expression time to ten minutes, and so forth.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

In particular they measured a notable decrease in the expression of RNA for CLOCK compared to controls.

«Our findings explain why mutations that decrease membralin expression would increase the risk for Alzheimer's,» Xu comments.

The mGlu2 decrease, they determined, resulted from an epigenetic change, which affects the expression of genes, in this case the gene that codes for mGlu2.

These drugs and other pathways decreased viral gene expression which suggested that the pathway the drugs blocked is important for the replication of EBOV.

Decreased nuclear HDAC activity results in global H3 acetylation, creating a permissive environment for cocaine - induced gene expression.

Remarkably, the relative expression levels of all marker genes were only slightly decreased when R206H ACVR1 and Q207D caACVR1 cultures were cotransfected with Noggin, whereas cells expressing the wild - type ACVR1 or empty viral vector showed clear downregulation of all analyzed marker genes for chondrogenesis.

PPI does not introduce any foreign genes into its products; rather it regulates the plant's own genes to increase or decrease expression of the genes responsible for key traits.

For example, 2xHAR.142 and 2xHAR.114, like many other HARs, function as enhancers, which increase or decrease the level of a gene's expression.

When they also looked for human genes with significantly higher or lower expression levels, they found 14 genes with increased expression and five with decreased expression.

In parallel, the mRNA expression of key transcriptional factors for Th1 cells (T - bet), Th17 cells (Rorc), and Tregs (Foxp3), as well as Ifng and Il17a, also were decreased in a dose - dependent manner (Supplemental Fig. 4D).

We found that ~ 90 % knockdown of ABL1 alone resulted in enhanced ABL2 expression and did not produce a significant decrease in the phosphorylation of CrkL, a reporter for the activation state of the ABL kinases (Fig. 2K), and did not inhibit metastasis (Fig. 2, L and M).

We found that a gene signature consisting of 273 genes important for breast cancer bone metastasis showed decreased expression in ABL1 / ABL2 knockdown cells (Fig. 6B)(38).

Although we found that manipulating GBP2 expression accounts for most of the alterations in body size in response to decreased TOR signaling, GBP1 also appears to play a role since knocking down both peptides induces stronger size reductions.

In the HepG2 cells, the expression of p53 reached a maximal level with treatment of 10 nM ActD, and decreased with doses of 100 nM or higher for 6 h (Fig. 1B).

PTC's GEMS technology exploits the regulatory mechanisms found in the untranslated regions of messenger RNA for the identification of small - molecule drugs that can treat diseases by selectively increasing or decreasing the expression of key proteins by modulating post-transcriptional mechanisms.

Consistent with the demonstration that LARP7 is necessary for the integrity of the 7SK snRNA (He et al., 2008), the reduced LARP7 expression in invasive breast cancer cell lines was accompanied by a decrease in 7SK snRNA (Figure 1D).

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

Results: Six months after the baseline measurement, there was a significant decrease in bullying behavior, drug use, smoking, binge drinking, excessive media use, sex without a condom, sex while using drugs or alcohol, sexual disinhibition, anger control, and anger expression for the FamTh - G compared with the CG.

A large body of research suggests that psychopathy is associated with atypical responses to distress cues (e.g. facial and vocal expressions of fear and sadness), including decreased activation of the fusiform and extrastriate cortical regions, which may partly account for impaired recognition of and reduced autonomic responsiveness to expressions of fear, and impairments of empathy.