Sentences with phrase «decreased expression of»

O - 3FA decreased expression of inflammatory genes and increased production of anti-inflammatory compounds in fatty tissue.

Furthermore, capsaicin decreased the expression of prostate - specific antigen (PSA) and inhibited the ability of the dihydrotestosterone to activate PSA.

There is evidence that people with genetically decreased expression of leptin receptors are more susceptible to certain infections.

In rodent models of T1D induced by streptozotocin, it was found that THC mitigated the severity of the immune response, transiently prevented hyperglycemia and loss of pancreatic insulin, and decreased expression of pro-inflammatory elements including CD3 + T cells, IL - 12, IFN - γ and TNF - α (50).

Increased expression of genes such as ABCG2 (37), CD44 (32), DNER (38) and ALDH1 (30), and decreased expression of ESR1 (34) support the use of this CSC enrichment method as all of these changes are expected in a CSC - enriched population.

Interestingly, BDNF expression was found to be regulated by FNDC5 in a cell - autonomous manner, and recombinant BDNF treatment led to the decreased expression of FNDC5 as part of a negative feedback loop.

We found that alcohol feeding resulted in decreased expression of bactericidal c - type lectins Reg3b and Reg3g.

Further, inactivation of the ABL kinases resulted in decreased expression of the genes in the Hippo, Janus kinase (JAK) / STAT, and cytokine / cytokine receptor pathway signatures (Fig. 6B).

We showed that inactivation of the ABL kinases in breast cancer cells resulted in decreased expression of genes in the JAK / STAT and cytokine / cytokine receptor pathway signatures, which may be due to decreased STAT5A mRNA expression and reduced STAT5 phosphorylation in ABL1 / ABL2 - depleted breast cancer cells.

In addition to inhibiting STAT5 signaling, we found that depletion of ABL kinases decreased the expression of the Hippo pathway mediator TAZ and downstream target genes in triple - negative and HER2 + breast cancer cells.

Similarly, there was decreased expression of c - FLIP, MCL - 1, and BCL - 2 after silencing of the mTOR gene (D).

They found a combination that did just that — increased expression of PDI1, decreased expression of MNN9, and deletion of PMR1 led to the highest yield of EGII.

Similarly, there was decreased expression of c - FLIP, MCL - 1, and BCL - 2 after silencing of mTOR (Fig. 6D).

During the multistep process of carcinogenesis, decreased expression of tumor suppressors is often caused by epigenetic modification or abnormal degradation (48, 49).

It has been reported that human breast CSCs and normal human mammary stem / progenitor cells showed decreased expression of miR200c and other miR200 members and that restoring miR200c in breast CSCs inhibits their ability to expand clonally and form tumors in vivo [38].

As shown in Fig. 5A, decreased expression of DDX3 at the protein level was found in 73 % of HCC from 26 patients.

Decreased expression of B7 costimulatory molecules and major histocompatibility complex class - I in human hepatocellular carcinoma.

Decreased expression of the glial water channel aquaporin - 4 in the intrahippocampal kainic acid model of epileptogenesis.

Accordingly, the increased p53 activity in p53Δ31 / Δ31 fibroblasts correlated with a decreased expression of 4 genes implicated in telomere syndromes.

Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.

A recent human study also indicated a genetic association of the αCaMKII gene with bipolar disorder, and decreased expression of αCaMKII has been observed in postmortem brains of patients with bipolar disorder.

Acute alcohol - treated FOXO3 - deficient mice developed more severe liver injury than that of wild - type mice, and this was attributed to decreased expression of autophagy - related genes.

They demonstrated that, similar to mouse, Rac1 inhibition resulted in impaired branching and decreased expression of AXIN2 and FGFR2b in human lung cultures.

Millar's group and her clinical collaborators, including Emily Chu, MD, PhD, an assistant professor of Dermatology and John McGrath, MD, from King's College, London, also discovered that cracking and scaling of palm and foot sole skin in WNT10A patients is due to decreased expression of a structural protein called Keratin 9, which is specifically expressed in these regions of skin and contributes to its mechanical integrity.

The researchers also looked at the gene expression of skin cells from people with psoriasis and found decreased expression of the genes involved in pigmentation signaling, correlated with increased amounts of IL - 17 and TNF.

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

Michaelsson G, Ahs S, Hammastrom I, Pihl Lundin I, Hagforsen E. Gluten - free Diet in Psoriasis Patients with Antibodies to Gliadin Results in Decreased Expression of Tissue Transglutaminase and Fewer Ki67z Cells in the Dermis.

This chimera, created by a team at the Georgia Cancer Center, has the ability to simultaneously decrease the expression of three growth factors that are over-expressed in some cancers.

By decreasing the expression of CerS4 in these mice, the Ogretmen laboratory hopes to better define the way in which CerS4 regulates cell migration and metastasis.

In the Cell Reports study, the authors hypothesized that if they could decrease expression of this subunit, they could improve cognitive function of AS model mice.

AMD3100, alone or in combination with VIC - 008, decreases expression of the immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway modulates PD - 1 expression.

Two mutations that decrease expression of this gene were found in high frequencies in people with the darkest skin.

Increasing or decreasing expression of Sirt4 in living flies allowed the researchers to discover what function Sirt4 played in the insects — and possibly in humans.

PPI does not introduce any foreign genes into its products; rather it regulates the plant's own genes to increase or decrease expression of the genes responsible for key traits.

In high carbohydrate diet - induced obesity, may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase / DLD in striated muscles, as well as that of selected glucose / pyruvate metabolic enzymes, hence affecting energy expenditure through mitochondrial metabolism (PubMed: 26671069).

Cyanidin increased SIRT6 enzyme levels in human colorectal cancer cells, and it was also discovered to decrease the expression of the Twist1 and GLUT1 cancer genes, while increasing the expression of the tumor suppressor FoXO3 gene in cells.

PTC's GEMS technology exploits the regulatory mechanisms found in the untranslated regions of messenger RNA for the identification of small - molecule drugs that can treat diseases by selectively increasing or decreasing the expression of key proteins by modulating post-transcriptional mechanisms.

«Dark chocolate, a high source of polyphenols, and flavanols in particular, has lately received attention for its possible role in modulating obesity because of its potential effect on fat and carbohydrate metabolism, as well as on satiety... The research undertaken to date has shown promising results, with the possible implication of cocoa / dark chocolate in the modulation of obesity and body weight through several mechanisms including decreasing the expression of genes involved in fatty acid synthesis, reducing the digestion and absorption of fats and carbohydrates and increasing satiety.»

Three new independently conducted studies show that the increased BHB produced in a ketogenic diet improved the NAD + / NADH ratio which decreases expression of the pro-inflammatory NF - κB gene, resulting in:

In the model estrogen - independent breast cancer, lunasin and aspirin administration inhibits cell proliferation, arrest cell cycle in S - phase as well as a decreases expression of cancer genes.

As expected, we find that inducing high self - esteem decreases expressions of materialism.

Not exact matches

Our study in an animal model found that influenza infection leads to an increase in the expression of muscle - degrading genes and a decrease in expression of muscle - building genes in skeletal muscles in the legs.

«Negative symptoms»: This includes lack of motivation or interest, diminished cognitive functioning, and decreased emotional expression.

One should not in this connection let himself be deceived by the observation that the abstract thinking of the Greeks made it possible for them to understand in its purity the essence of the spiritual, and that therefore mythological, anthropomorphic ideas of God were abandoned by the Greeks, while in Judaism naïve mythological and anthropomorphic expressions about God, although they decrease, do not by any means disappear.

I can only barely convey the context of meaning and quality without which sexual expression becomes a ritual of decreasing satisfaction in the lives of persons.

Religious programs act as a functional alternative to the local church, thus decreasing attendance and involvement by reinforcing the social tendency toward the individualizing of religious experience at the expense of its corporate expressions, and placing a burden on the religious broadcasting organizations which they are not equipped to handle.

He was using an expression of St John the Baptist in the New Testament: «I must decrease.

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS - 2.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.