Sentences with phrase «decreased over time due»

Standard fixed - income investments come with the risk that the purchasing power of your interest payments could be decreased over time due to inflation.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The price of a Bitcoin can unpredictably increase or decrease over a short period of time due to its young economy, novel nature, and sometimes illiquid markets.

A baby who is fussy and jittery from caffeine stimulation may not nurse well, however, which could lead to a decreased milk supply over time (due to decreased nursing, rather than the mother's caffeine intake).

Additionally, due to inflation, the value of a loan decreases over time.

«Heat - related deaths have been decreasing over time in part due to the development of warning systems that have increased awareness of what to do and saved lives,» he says.

All this being said, the increase in your metabolism and the decrease in eating due to protein consumption can lead to significant weight loss over time.

The bottom may move up, but I suspect over time, to the see those high scores go down and the achievement gap will be narrowed but not due to an increase from the bottom, but a decrease from the top.

Due to the highly competitive nature of the unsecured loan market, the interest rate charged for unsecured loans has been decreasing over the years and at the present time unsecured loans» interest rate does not differ much from secured loans» rate.

The reverse of a traditional loan also occurs: debt increases over time (due to the borrower not making any payments on the loan) while equity decrease.

If you first decide to not have surgery performed but change your mind later, it is quite possible that surgery can not be performed at a later date due to the decreasing surgical success rate over time.

At age two months there should be 12.9 survivors, roughly six females and seven males (at maturity, roughly 2/3 of the stray cat population is male, (6) due to the high mortality of females during first pregnancy and birth), which will decrease to four females over time.

By the mid-Holocene period, 6000 - 5000 years ago, glacial melting had essentially ceased, while ongoing adjustments of Earth's lithosphere due to removal of the ice sheets gradually decreased over time.

Here's an overview from NASA: By the mid-Holocene period, 6000 - 5000 years ago, glacial melting had essentially ceased, while ongoing adjustments of Earth's lithosphere due to removal of the ice sheets gradually decreased over time.

The data and the statistical analysis does not provide the evidence that the so called «pause», a time period with a lower trend estimate than the longer - term trend estimate, was more than just a short - term fluctuation around the median warming trend, mostly due to short - term unforced internal variability in the Earth system (and some contribution from decreasing solar activity and increased reflecting aerosols in the atmosphere, counteracting the increased greenhose gas forcing to some degree), like the «acceleration» over the 16 - year period from 1992 to 2007 (e.g., UAH trend: 0.296 + / - 0.213 (2 sigma) deg.

To claim that the global avg temp might as well have decreased 0.7 degrees as increased 0.7 degrees since preindustrial times flies in the face of basic physics, namely that the planetary temperature is governed (a.o.) by the planetary energy balance, and that this balance has substantially changed over the past 100 or so years due in large part to anthropogenic climate forcings, with a bit of help from natural climate forcings.

These policies can be used with those who are covering the payoff of a home mortgage, where the balance that is due decreases over time.

There may be other reasons why stress, anxiety and depression decreased over this period of time; it may be due to regression to the mean.

Conduct - disordered youth exhibit a decreased dopamine response to reward and increased risk - taking behaviors related to abnormally disrupted frontal activity in the anterior cingulate cortex (ACC), orbitofrontal cortices (OFC), and dorsolateral prefrontal cortex (DLPFC) that worsens over time due to dysphoria activation of brain stress systems and increases in corticotropin - releasing factor (CRF).

The IRS lets you deduct a portion of your property every year because they treat it as your property decreasing in value over time due to wear and tear, deterioration, and age.