Sentences with phrase «decreased the ability of»

Diabetes is the decreased ability of your body to use glucose, especially in the form of simple, refined sugars.

RBS chief executive Stephen Hester told the Commons» Treasury committee reflected those of many in the City when he warned: «I believe that creating a ring - fence increases somewhat the systemic risk and decreases the ability of banks to withstand the risk and has significant costs.»

However, the reduction in the numbers of stomatal pores decreases the ability of plants to cool their leaves during a heat wave via water evaporation.

BRAF mutations, which occur in about 40 to 50 percent of these patients, have been associated with aggressive tumors and decreased ability of tumors to respond to radioactive iodine, typically the first line of treatment in these patients.

The SMARt - 420 could periodically clear out bacteria that had developed resistance to ethionamide through ethA, and the intermittent exposure would «dramatically decrease the ability of bacteria to develop resistance,» predicts senior author Alain Baulard, also of the University of Lille.

«Plus the chemicals in these scents are similar to those emitted from exhaust engines and we found that pollutant concentrations equivalent to urban environments can decrease the ability of pollinators to find flowers.»

Hensley and his team reported this egg - induced mutation, which was present in the 2016 — 17 U.S. seasonal flu vaccine, decreases the ability of certain antibodies to attach to and destroy the flu virus — by a whopping three orders of magnitude.

The elevation is caused by insulin resistance (decreased ability of the body to respond to insulin) and by decreased insulin production by the pancreas.

Nutritional deficiencies impair lung growth, favour infections and decrease the ability of cells to control inflammatory processes, for example through a lack of anti-oxidative factors.

Ultimately, 85 compounds were identified that decreased the ability of MRSA to kill laboratory roundworms.

The more inflamed we are, the more we decrease ability of our body to absorb nutrition.

For older age groups, vitamin B12 is often caused by the decreased ability of the digestive system to absorb nutrients.

In the pancreas, elevated free fatty acids decrease the ability of two proteins called FOXA2 and HNF1A to travel to the nucleus and bind to DNA.

Reduced metabolic activity of brain cells and neurons means less brain activity and a decreased ability of the brain to clear abnormal structures like the beta - amyloid plaques associated with Alzheimer's disease.

High levels of cortisol also decrease the ability of osteoblasts to synthesize new bone and interfere with absorption of Ca2 + from the gastrointestinal tract.

With the onslaught of acidity from foods and stress along with decreasing ability of the body to keep up with buffering all this acidity our bodies often can not keep up adequately with sufficient production of bicarbonates (especially true as we age or if we have a chronic stress).

Caffeine boosts energy temporarily by raising cortisol, but as we've seen, high cortisol can block progesterone receptors: your daily jolt may be decreasing the ability of your progesterone to bind to its receptor and do its job.

Much less water would flow, which in turn would decrease the ability of the hose to squirt out the marbles.

In addition, the overall phenolic content of EVOO has been associated with a decreased ability of cancer cells to regenerate.

Instead, eliminating affirmative action has decreased the ability of black students to attend public colleges across the board, with a pronounced effect in less selective institutions.

It lowered construction, reduced wealth and thereby consumer spending, decreased the ability of financial firms to lend, and reduced the ability of firms to raise funds from securities markets (Duca and Muellbauer 2013).

Make sure your grooming schedule is regular enough to keep your dog's hair from getting matted, which significantly decreases the ability of your dog's fur to keep him insulated.

Urinalysis — which may show protein in the urine due to decreased ability of the kidneys to metabolize the molecule and hematuria

After estrus, progesterone levels remain high for 8 - 10 weeks causing thickened uterine lining and decreased ability of uterine walls to contract.

Canine dilated cardiomyopathy (DCM) is a primary disease of cardiac muscle that results in a decreased ability of the heart to generate pressure to pump blood through the vascular system.

As is the case with all influenza viruses, there is the opportunity for changes in the virus that could affect transmission rates and increase or decrease the ability of the virus to cause respiratory illness.

Hospitalized dogs are commonly malnourished due to decreased food intake which can lead to decreased immune system function, decreased ability of the body's tissues to repair and restore themselves, and abnormal drug metabolism.

While these dead zones are often caused by fertilizer runoff currently, it seems the decreasing ability of the oceans to hold dissolved oxygen with continued warming will increasingly become a problem for marine ecosystems and fisheries in the coming decades.

Ocean acidification can decrease the ability of marine organisms to build their shells and skeletal structures and kill off coral reefs, with serious effects for people who rely on them as fishing grounds.

A warmer troposphere can decrease the ability of the ocean to remove and store CO2 by decreasing the nutrient supply for phytoplankton and increasing the acidity of ocean water.

To the extent that large law firms are no longer able to offer their lawyers meaningful opportunities to exercise and develop practical wisdom and professional judgment, that is, insofar as they are not able to sustain a credible promise to produce high quality work and provide quality training and mentorship to their associates, and as the number of large law firms continues to grow, decreasing the ability of each individual firm to represent a high number of elite clients, the large firms may find themselves unable to sustain a credible claim to elite professional status.

Not exact matches

Anything less than this is considered to be inadequate, which can limit your motivation, increase the release of cortisol (a stress hormone), as well as decrease your body's ability to recover from exercise — all of which are damaging to your health and fitness routine.

I expect, however, that there will be three first - order effects that will be very similar to those that followed the BP spill: 1) increased public consciousness of the dangers inherent in transporting oil and oil products and more aversion to having these products moved nearby; 2) increased calls for alternatives to oil rather than alternative means of transporting oil; and 3) decreased trust in regulators» and firms» abilities to sufficiently mitigate risks from transporting oil.

Research over the years has shown that abusive workplaces add insurmountable amounts of stress on employees, greatly decreasing their ability to focus and be productive.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

The number of firms reporting that labour shortages are restricting their ability to meet demand decreased somewhat, returning to the levels observed since 2014 (Chart 6, blue bars).

When investors pay this much of taxes, it usually decreases their credit crippling their ability of buying properties.

For in - house recruiters, the ability to share applicant information with the relevant hiring manager, as well as schedule interviews and gather feedback from those same hiring managers within one system can save time and decrease the number of days in the hiring cycle.

Additionally, our customers have the ability to cancel purchase orders in the event of any delays in production and may decrease future orders if delays are persistent.

If credit conditions worsen, and adversely affect the ability of customers to finance potential purchases at acceptable terms and interest rates, it could result in a decrease in sales of our products or delay any improvement in our sales.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

JED has been described as «an ecumenical sharing of abilities and expertise» and a partnership which makes «good, economic sense in these days of decreasing financial resources for the work of the church.»

The adverse effects of malnutrition increase the body's exposure to infection while at the same time decreasing its ability to fight the infection.

The formation of the white blood cells, essential in fighting infection, is reduced in severe PEM, and the ability of white blood cells to engulf and consume bacteria is decreased.

By encouraging dependency on himself, a minister decreases his people's ability to function as adult decision - makers and initiators of action.

Wheat and corn production already has been declining and the ability to catch fish in areas of the tropics is expected to decrease by 40 to 60 percent.

Supercharge Your Gut will teach you how to enhance your ability to listen to your body, increase your energy, decrease your brain fog and give you a whole new sense of vitality.

VAD can damage the immune system and decrease the body's ability to resist or fight infections, therefore increasing the risk of mortality from common diseases especially among young children.

The ability to provide consistent product, reliable supply and regular and transparent assurance that Australian food products are safe not only allows market access in these regions, but also enables the charging of premium prices and decreases the potential for non-tariff barriers.