Researchers have found that BDNF levels decline progressively with age.10 Lommatzsch, M., et al. «The Impact
of Age, Weight and Gender on BDNF Levels in Human Platelets and Plasma,» Neurobiology
of Aging 26 (2005):... continue At the same time that BDNF levels
decrease, the
volume of the hippocampus (primary center for emotion and memory) also decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... co
volume of the
hippocampus (primary center for emotion and memory) also
decreases.11 Erickson, K.L., et al. «Brain - Derived Neurotrophic Factor is Associated with Age - Related Decline in Hippocampal
Volume, Journal of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal of... co
Volume, Journal
of Neuroscience 30,... continue In fact, in some neurological diseases, such as Huntington's and Alzheimer's disease, BDNF levels are low or deficient.12 Laske, C., et al. «
Decreased Brain - Derived Neurotrophic Factor (BDNF) and B - Thromboglobulin Blood Levels in Alzheimer's Disease,» Journal
of... continue
Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the
hippocampus and amygdala, with dendritic atrophy observed in the
hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived
of maternal nurturance show
decreased hippocampal
volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects
of early relative deprivation on cognitive outcomes.16
Specifically, we found that smaller
hippocampus volumes and greater responses to sad faces in emotion reactivity regions predict increased depressive symptoms at the time
of scan, whereas larger amygdala
volumes, smaller insula
volumes, and greater responses in emotion reactivity regions predict
decreased emotion regulation skills.