Sentences with phrase «decreases its availability in»

Because processing decreases its availability in the diet, Taurine is added to many Holistic Select recipes at guaranteed levels.

Availability of resources such as usable water will also depend on changing rates of precipitation, with decreased availability in many places but possible increases in runoff and groundwater recharge in some regions like the high latitudes and wet tropics.

Not exact matches

The study notes that a 99 % population increase since 1950 combined with a 127 % increase in water use has further decreased water availability, making it increasingly difficult to replenish water supplies after a drought.

As the availability of capital decreases, you tend to get a decline in risk tolerance on a whole range of issues, including R&D.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

These risks include, in no particular order, the following: the trends toward more high - definition, on - demand and anytime, anywhere video will not continue to develop at its current pace or will expire; the possibility that our products will not generate sales that are commensurate with our expectations or that our cost of revenue or operating expenses may exceed our expectations; the mix of products and services sold in various geographies and the effect it has on gross margins; delays or decreases in capital spending in the cable, satellite, telco, broadcast and media industries; customer concentration and consolidation; the impact of general economic conditions on our sales and operations; our ability to develop new and enhanced products in a timely manner and market acceptance of our new or existing products; losses of one or more key customers; risks associated with our international operations; exchange rate fluctuations of the currencies in which we conduct business; risks associated with our CableOS ™ and VOS ™ product solutions; dependence on market acceptance of various types of broadband services, on the adoption of new broadband technologies and on broadband industry trends; inventory management; the lack of timely availability of parts or raw materials necessary to produce our products; the impact of increases in the prices of raw materials and oil; the effect of competition, on both revenue and gross margins; difficulties associated with rapid technological changes in our markets; risks associated with unpredictable sales cycles; our dependence on contract manufacturers and sole or limited source suppliers; and the effect on our business of natural disasters.

According to Living Goods, clients may also be reluctant to buy drugs from other private providers because of the risk of getting a counterfeit medicine.63 Living Goods sent us a study conducted at the midline of its RCT that claims that both availability of counterfeit drugs and drug prices decreased at private retailers in areas where CHPs worked.64 According to the study, about 37 % of private drug shops in the areas it studied sold fake ACT drugs, 65 and availabilty of fake ACTs was about 50 % lower among non-Living Goods sellers in the areas where Living Goods worked.66 Additional results on these potential effects will be made available when the full RCT is published.

WASHINGTON, D.C. (December 10, 2013)-- Mortgage credit availability decreased slightly in November according to the Mortgage Credit Availability Index (MCAI), a report from the Mortgage Bankers Association (MBA) which analyzes data from the AllRegs ® Market Claritavailability decreased slightly in November according to the Mortgage Credit Availability Index (MCAI), a report from the Mortgage Bankers Association (MBA) which analyzes data from the AllRegs ® Market ClaritAvailability Index (MCAI), a report from the Mortgage Bankers Association (MBA) which analyzes data from the AllRegs ® Market Clarity ® product.

WASHINGTON, D.C. (October 8, 2013)-- Mortgage credit availability decreased in September according to the Mortgage Credit Availability Index (MCAI), a report from the Mortgage Bankers Association (MBA) which analyzes data from the AllRegs ® Market Clarity ® product.The availability decreased in September according to the Mortgage Credit Availability Index (MCAI), a report from the Mortgage Bankers Association (MBA) which analyzes data from the AllRegs ® Market Clarity ® product.The Availability Index (MCAI), a report from the Mortgage Bankers Association (MBA) which analyzes data from the AllRegs ® Market Clarity ® product.The MCAI decreas

Businesses owned by Latinos, African - Americans, and women have seen an enormous decrease in availability of credit - both in loans guaranteed by the Small Business Administration and conventional loans.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

With an overall decrease in both water availability and water quality across the country, Horizon Elite represents a huge win for operators and for the industry.»

In addition to leading the way for other brands to begin removing toxins from their products, this shift could likely impact the global supply market in upcoming years, increasing the availability (and decreasing the cost) of higher quality plant - based ingredients or safer chemicals that could be used in personal care products across marketIn addition to leading the way for other brands to begin removing toxins from their products, this shift could likely impact the global supply market in upcoming years, increasing the availability (and decreasing the cost) of higher quality plant - based ingredients or safer chemicals that could be used in personal care products across marketin upcoming years, increasing the availability (and decreasing the cost) of higher quality plant - based ingredients or safer chemicals that could be used in personal care products across marketin personal care products across markets.

[NYO] • Commercial rental rates in Manhattan decreased 2.2 percent in the second quarter and availability is up 8.2 percent — the first time since 2005 that rents have declined and availability is so high.

So, the researchers argue, a major decrease in availability of the element would have had catastrophic effects on the ocean's ecosystems — and thus may have caused, or at least played a major role in, the widespread die - offs.

Similarly, studies by Ferguson and by other researchers, such as economist Todd Kendall, have found a decrease in rates of rape that coincides with increased availability of pornography.

Scientists say reserves can help marine ecosystems and people adapt to five key impacts of climate change: ocean acidification; sea - level rise; increased intensity of storms; shifts in species distribution, and decreased productivity and oxygen availability.

Though not definitive, recent research also suggests that noise - induced stress may decrease dopamine availability in the prefrontal cortex, where the hormone controls the flow of information from other parts of the body.

«The ACR welcomes the introduction of biosimilars to the U.S. healthcare system and is hopeful that the decrease in cost resulting from the availability of safe and effective biosimilars in the U.S. will increase our patients» access to life - changing therapies and improve their overall health.

If the body temperature drops, such as when an animal goes into hibernation, TBG's affinity for thyroxine increases, resulting in a decrease in the availability of the hormone and a decrease in metabolism.

At the same time, another 23 % have experienced a significant decrease in water availability, for 9 % aggravating water scarcity problems.

This simple numerical comparison (leaving aside other factors affecting the classrooms in Spanish universities such as the large number of students in many centers and the increase in the type of «unquantifiable» work that this generates for teaching staff) shows that the «civil servant professor» has a significant decrease in availability of time for research compared to members of research - only institutes.

75 percent showed decreases in psychological meaningfulness, psychological availability and psychological safety

In their upcoming second Ecological Restoration publication titled «Resurgence of Native Plants After Removal of Amur honeysuckle from Bender Mountain Preserve,» Conover and Sisson reveal the lengths to which honeysuckle alters habitats by decreasing light availability and depleting soil moisture and nutrients, as well as by possibly releasing toxic chemicals that prevent other plant species from growing in the vicinitIn their upcoming second Ecological Restoration publication titled «Resurgence of Native Plants After Removal of Amur honeysuckle from Bender Mountain Preserve,» Conover and Sisson reveal the lengths to which honeysuckle alters habitats by decreasing light availability and depleting soil moisture and nutrients, as well as by possibly releasing toxic chemicals that prevent other plant species from growing in the vicinitin the vicinity.

Policies targeting healthy food availability in corner stores have the potential not only to increase healthy food availability but also to decrease health disparities.»

«Climatic refuges, such as mature tropical forests, may be important for many resident tropical bird species faced with the decreasing availability of mature forests coupled with increases in the severity of El Niño - associated dryness.»

For instance, the IPCC concluded that by 2050, «freshwater availability in central, south, east and south - east Asia, particularly in large river basins, is projected to decrease».

decrease funding requests for same models by promoting their analysis and their storage in data bases, to guarantee coming availability into and for scientific community

Though we did not find a full trophic cascade in our systems, previous research has shown increased floating algae decreases the availability of light to the attached algae below, thus decreasing the abundance of important resources for grazers like tadpoles and snails.

Deficiencies of B12, B6, folic acid and / or iron can all create a shift in fuel availability (specifically in glycolysis: the oxidation or burning of sugar / glucose) which is a huge stressor on the body as it decreases oxygen availability to every cell.

For weight loss, decreased hunger can be beneficial, but by adding reduced hunger cues on top of hours and hours of training each week, you may inadvertently find yourself in a state of low energy availability (due to under - eating).

Aging - associated increases in oxidative damage to key enzymes results in their structural deformation and decreased binding affinity for the co-enzyme, causing a decrease in enzyme funtion.8 Ames» research has demonstrated that increasing the availability of acetyl L - carnitine and α - lipoic acid, two nutrients that serve as mitochondrial enzyme co-factors, restores the velocity of the reactions (KM) in the related enzymes, and thus restores aging mitochondria's ability to produce youthful levels of ATP.9 10 11 12 13 Part II focused on the inter-relationships among the folate, methylation and transsulfuration pathways, whose dysfunction results in increased free radical production coupled with disruption of glutathione (GSH) synthesis, thus accelerating mitochondrial decay and aging.

Over-inhibition of 5AR results in increased availability of testosterone, which may be shunted, via aromatase, to estradiol, causing «feminization,» e.g., gynecomastia, one of the side effects of 5AR inhibitor drugs; and decreased production of not only 5α - DHT, but its metabolites, 5α - Androstane - 3α - 17β - diol (aka 3α - adiol, a storage form of 5α - DHT), and 5α - Androstane - 3β - 17β - diol (aka 3β - adiol), an estrogen receptor beta (ERβ) ligand that promotes normal cellular differentiation, thus lessening risk of benign prostatic hypertrophy and prostate cancer.22, 23, 24

In contrast, reliance on carbohydrate decreases and fat oxidation increases during exercise following a low - carbohydrate, high - fat diet (and in some cases, increasing fat availability immediately before exercise can actually increase endurance performance, as well as enhance recovery), and a «fat adapted» athlete may rely more on mitochondrial respiratioIn contrast, reliance on carbohydrate decreases and fat oxidation increases during exercise following a low - carbohydrate, high - fat diet (and in some cases, increasing fat availability immediately before exercise can actually increase endurance performance, as well as enhance recovery), and a «fat adapted» athlete may rely more on mitochondrial respiratioin some cases, increasing fat availability immediately before exercise can actually increase endurance performance, as well as enhance recovery), and a «fat adapted» athlete may rely more on mitochondrial respiration.

I've since taken to soaking and then drying almonds and sunflower seeds in a low heat oven, a la Sally Fallon, in an effort to decrease phytic acid and increase mineral availability.

These chronically elevated levels of cortisol can also causes catabolism (decreased protein availability in skeletal muscles) as well as a redistribution of body fat from your legs and arms to your belly.

A large decrease in price and increase in availability have given more people access to this drug.

Low energy availability results in fatigue and a decrease in subsequent energy and activity levels.

(a) The oxidative catabolism of free fatty acids and amino acids (via the Respiratory Chain and Citric Acid Cycle) might be inhibited in hypoxic cancer cells via the judicious use of agents which inhibit their availability, i.e., partially inhibit hepatic fatty acid synthesis and keep plasma amino acid levels within the normal range, thus decreasing ATP production;

It inhibits anabolic signaling pathways when cellular ATP levels are decreased and AMP levels increase in response to limited energy availability (31).

In response to negative energy balance, mRNA translation and muscle protein synthesis may be down - regulated as a result of decreased nutrient and growth factor availability, causing reduced mTORC1 activation.

The exponential growth of the use and availability of smartphones and tablets, combined with the decrease in acquisition costs of these devices, make a suitable learning tool for special needs children.

This combination of diminished supply in the pipeline, decreasing availability of career educators, and increased demand on existing teachers could lead to a crisis that threatens our system of public education.

[Mr. Scott] intends to review his investment in [ASYS] on a continuing basis and, depending upon the price and availability of shares of the Common Stock, subsequent developments affecting [ASYS], [ASYS]'s business and prospects, other investment and business opportunities available to [Mr. Scott], general stock market and economic conditions, tax considerations and other factors considered relevant, may decide at any time to increase or to decrease the size of his investment in [ASYS].

These diets should contain highly digestible carbohydrates, such as white rice and potato or barley, in order to increase nutrient availability and decrease osmolar effects.

The availability of cost - competitive cultured animal products has the potential to cause a massive decrease in the demand for non-cultured animal products.

Lenders who cater to the profession or have large numbers of veterinary customers say they've seen some decrease in loan availability this year.

Secondly, this sees a significant decrease in the number of Business Class seats available on the route and that's not going to be good for upgrades or the already pathetic award availability.

This means that you need to book these affected properties ASAP if they are going to increase, or in the event your desired property is decreasing, you probably want to wait until those changes come into effect (you should be able to rebook them at the changed price, subject to availability in any event).

And the decrease in Air France transatlantic award availability isn't all that different than what we've seen with Lufthansa lately.