In normal - weight mice, activation of this receptor
decreases orexin A release.
Not exact matches
Activating these CB1 receptors
decreases inhibition of the
orexin neurons, increasing
orexin A release and food consumption.
Interestingly, sleep deprivation markedly increased the buildup of Aβ in the brain of a mouse model of AD; whereas a drug that block
orexin actions markedly
decreased the buildup of Aβ.