Twelve - hour exposure of 3T3 - L1 adipocytes to H (2) O (2) or TNF -
alpha resulted in the increase of c - Jun NH (2)- terminal kinase (JNK) activation and insulin
receptor substrate 1 (IRS1) serine 307 phosphorylation, concomitantly with the
decrease in insulin - stimulated IRS1 tyrosine phosphorylation and cellular glucose uptake.