Sentences with phrase «decreasing levels from»

However, the reduction of glycogen synthesis, glycolysis, and glucose oxidation was more pronounced within the group of men, with decreasing levels from normal - weight to obese and T2DM group (296).

Not exact matches

In particular Women who vacationed at least two times per year were less likely to suffer from depression and had decreased levels of stress.

The refinance share of mortgage activity decreased to 46.4 percent of total applications, its lowest level since July, from 47.8 percent the previous week.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The expectations component of the survey generally remained stable as well, although the average likelihood of applying for all types of credit over the next 12 months decreased slightly from their June levels.

Debt levels among elderly and near elderly have decreased from their peaks in 2010.

The employment index climbed to 15.9 from 15.3, the part - time employment index decreased to 3.7 from 5.1, the hours worked index dipped to 8.0 from 8.3, the wages and benefits index grew to 23.5 from 20.9, the input prices index fell to 27.9 from 29.2, the selling prices index increased to 19.2, its highest level in over 10 years, from 17.0, the capital expenditures index slid to 16.0 from 17.6, the general business activity index rose to 14.5 from 13.4.

This is distinct from but similar to price deflation, which is a general decrease in the price level, though the two terms are often mistaken for each other and used interchangeably.

The frequency of extreme events has either not changed or has decreased in the 150 years that CO2 levels have increased from 270 to 390 ppm.

The main findings were that Commonwealth environmental water extended the presence of Golden perch larvae through summer, decreased salinity levels in the Lower Lakes and the Coorong improving available habitat for native fish, and exported an estimated 600 000 tonnes of salt from the Basin through the Murray Mouth.

Environmental water was delivered between January and February to manage the recession from high natural flows during late December / early January and ensure that river levels decreased gradually.

As a banana ripens, transforming from green to yellow to spotted to black, the sugars are developing while the starch level is decreasing

Hemp seeds also contain high levels of vitamin E, which will decrease inflammation in the body lowering your risk of cancer and heart disease as well as ease pain from arthritis.

Medium - chain triglycerides: Scientific literature review investigating the potential of medium chain triglycerides and medium chain fatty acids (found in virgin coconut oil) for increasing thermogenesis, decreasing body fat, reducing risk of cardiovascular disease, stabilizing insulin levels for people with diabetes type 2, reversing intestinal inflammation, and protecting the liver from hepatotoxicity

Skipping a meal also means the body starts pulling energy from different reserves which affect thyroid hormone levels as well as decrease production of insulin.

According to Dr. Jennifer Peterson, from the Cleveland Clinic Children's, «Kangaroo care can actually decrease the heart rate, improve the breathing pattern, improve the oxygen levels in the premature babies.

Crime dropped overall by one - fourth of one percent in 2013, McCarthy said, acknowledging «that may not sound like much,» but then he quickly mentioned the 16 percent decrease in 2012 from 2011 levels.

And animal research has linked even low - level exposure to everything from female reproductive disorders, early puberty, early - stage breast and prostate cancer, and decreased sperm count to attention and developmental problems.

Mothers who dropped cow's milk products from their diet showed decreased levels of milk - specific IgA in their breast milk, which is thought to protect against development of allergies, according to Kirsi Järvinen, MD, PhD, of Albany Medical College in Albany, N.Y.

Despite a 56 % decrease in the national incidence of sudden infant death syndrome (SIDS) from 1.2 deaths per 1000 live births in 19921 to 0.53 death per 1000 live births in 2003,2 SIDS continues to be the leading cause of postneonatal mortality in the United States.3 The decreased rate of SIDS is largely attributed to the increased use of the supine sleep position after the introduction of the «Back to Sleep» campaign in 1994.4 - 7 More recently, it has been suggested that the decrease in the SIDS rate has leveled off coincident with a plateau in the uptake of the supine sleep position.8 Although caretakers should continue to be encouraged to place infants on their backs to sleep, other potentially modifiable risk factors in the sleep environment should be examined to promote further decline in the rate of SIDS.

They concluded that, «DHS consumption during pregnancy - at levels that are reasonably attained from foods - has the potential to decrease symptoms of postpartum depression.»

The most recent study report described in these same regions decreased tissue levels of 5 - HT and tryptophan hydroxylase, the synthesizing enzyme for serotonin, and no evidence of excessive serotonin degradation as assessed by levels of 5 - hydroxyindoleacetic acid (the main metabolite of serotonin) or ratios of 5 - hydroxyindoleacetic acid to serotonin.30 A recent article described a significant association between a decrease in medullary 5 - HT1A receptor immunoreactivity and specific SIDS risk factors, including tobacco smoking.40 These data confirm results from earlier studies in humans39, 41 and are also consistent with studies in piglets that revealed that postnatal exposure to nicotine decreases medullary 5 - HT1A receptor immunoreactivity.42 Animal studies have revealed that serotonergic neurons located in the medullary raphe and adjacent paragigantocellularis lateralis play important roles in many autonomic functions including the control of respiration, blood pressure, heart rate, thermoregulation, sleep and arousal, and upper airway patency.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

Any final verdict will probably depend on whether there are further strikes from the U.S., upon Russia's and Syria's reactions, and particularly whether the strikes can be shown to increase or decrease the levels of violence and acts of barbarism from Assad.

Under 2007 BASE Budget County funding, full - time staffing will have DECREASED 361.5 positions and 63 % from 1975 levels while Erie County's population decreased from 1,113,491 in the 1970 census to 950,265 in the 2000 census, a 1DECREASED 361.5 positions and 63 % from 1975 levels while Erie County's population decreased from 1,113,491 in the 1970 census to 950,265 in the 2000 census, a 1decreased from 1,113,491 in the 1970 census to 950,265 in the 2000 census, a 15 % drop.

They should be totally innoculated from hardships we adults face in a down economy — you know, like unemployment, decreased services, higher taxes, catastrophic losses of principal in our 401 (k), staggering levels of governmental incompetence....

Under the 2008 BASE Budget County funding, full - time staffing will have DECREASED 346.5 positions and 60 % from 1975 levels while Erie County's population decreased 15 % from 1,113,491 in the 1970 census to 950,265 in the 200DECREASED 346.5 positions and 60 % from 1975 levels while Erie County's population decreased 15 % from 1,113,491 in the 1970 census to 950,265 in the 200decreased 15 % from 1,113,491 in the 1970 census to 950,265 in the 2000 census.

Bacteria levels in the water at Nassau County beaches decreased slightly from 2011 to 2012, while levels at Suffolk County beaches stayed the same, according to a report released Wednesday.

Even Hein's Republican opponent apparently missed that report, in which fellow Democrat Auerbach wrote, «At the close of 2015, the county will have nearly tripled (his emphasis) the level of fiscal stress from the prior year due to deficit budgeting and decreasing fund - balance levels.

The researchers recommended this light level — equivalent to a 100 - times decrease from daylight illumination — for routine testing.

Using the Great Barrier Reef as their study case, they estimated the evolution of the region over the last 14,000 years and showed that (1) high sediment loads from catchments erosion prevented coral growth during the early phase of sea level rise and favoured deep offshore sediment deposition; (2) how the fine balance between climate, sea level, and margin physiography enabled coral reefs to thrive under limited shelf sedimentation rates at 6,000 years before present; and, (3) how over the last 3,000 years, the decrease of accommodation space led to the lateral extension of coral reefs consistent with available observational data.

According to figures from the World Bank, the Chinese economy's carbon intensity — the amount of CO2 emissions relative to the size of economic output — has decreased by almost 70 per cent over the past three decades (see «Peak planet: Carbon dioxide intensity «-RRB-, and a further 20 per cent reduction from current levels is promised by 2020.

Taken together, the research data provides a picture, from the leaf scale to the global scale, suggesting that droughts in the Amazon basin are affecting levels of carbon dioxide in the atmosphere globally, both on a short - term basis though decreasing photosynthesis and on a longer term basis, by increasing tree mortality.

But the data in this latest study also revealed something puzzling: falling levels of BPA in urine when 2006 measurements were compared with 2004; concentrations decreased from an average of 2.49 to 1.79 nanograms per milliliter.

«If everyone's protein intake were at this level, that would translate to more than 1.4 million fewer deaths from stroke each year worldwide, plus a decreased level of disability from stroke,» said Liu.

Since the pollution concentration decreases from west to east, as the distance from Los Angeles increases, the forests offered a rare opportunity to compare emissions from wildland fuels subjected to different levels of chronic air pollution.

When the Stanford team measured pyrophosphate levels in cultured cells derived from ank and normal mice, they found that the chemical accumulated in cells from the ank mice but decreased in the culture medium.

«Findings from other research indicate that as we become a more abundant society, our aggregate average creativity levels decrease,» Mehta said.

In experiments performed with actual officers during a video simulation of a confrontation, a team from Vrije University Amsterdam found that shooting accuracy, arrest and self - defense skills and communication all decreased when stress levels are high, and that officers fired more often in a high - anxiety situation on suspects that had already surrendered.

«For example, in the future methane levels could increase as a result of increased natural gas and energy use, climate change feedbacks and / or a decrease in the global abundance of the hydroxyl radical, which chemically removes methane from the atmosphere.»

Physical activity decreases substantially over time in patients with chronic obstructive pulmonary disease (COPD) at all levels of severity, according to a new study from researchers in Germany.

«When these dates were compared with radiocarbon data from tree rings, we noted decreased levels of carbon - 14 — indicating increased levels of solar activity — at these same points.»

Researchers report that decreasing water pH — one consequence of rising levels of carbon dioxide in the atmosphere — dissolves the stony coral's hard skeleton but does not dislodge the soft - bodied polyps from their rocky substrate.

«These findings suggest that while pentaBDE levels have been decreasing since the phase - out, they continue to be detected in the blood of young children nearly 10 years following their removal from U.S. commerce,» says first author Whitney Cowell, PhD, pediatric environmental health research fellow at Mt. Sinai and former doctoral student from the Columbia Center for Children's Environmental Health.

When they prevented the cells from making ALKBH5, NANOG levels and the number of cancer stem cells decreased.

Samples collected by Kocaeli University Hospital, Turkey from children born of nutritionally vitamin B12 - deficient mothers also showed a significant decrease in levels of vitamin B12 and taurine.

People in the study with more severe stages of the disease did not have lower levels of caffeine in the blood, suggesting that the decrease occurs from the earliest stages of the disease, according to David G. Munoz, MD, of the University of Toronto in Canada, who wrote an editorial accompanying the study.

They found that while bunch rot actually led to more positive aroma ratings due to the increased levels of fruity - and vanilla - like notes, powdery mildew decreased the level of pleasant notes in the wine, so that it received more negative ratings from the test panel, who found the infected wine to be less interesting than the healthy sample.

The vegetation concomitantly changed from a slough assemblage of aquatic and semiaquatic plants to communities of sawgrass and pine, which began to dominate as the water table fell and the nutrient levels decreased.

Over the past 200,000 years, replacement - level fertility rates have ranged from 2.1 to 3.0 children per couple, he said, noting that global population remained remarkably stable until the beginning of the 19th century, when decreased mortality in newborns resulted in fertility rates exceeding replacement levels.