For the study, the researchers created a line of zebrafish
with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune system.
Using mice
with defective immune systems, Miller's research team found that after an initial exposure of the skin to staph, they were surprisingly protected against a second skin exposure with the same bacteria.
«Most work done in this field has tested virotherapy in human tumors implanted into mice with
defective immune systems,» said Dr. Cripe, also a principal investigator in the Center for Childhood Cancer and Blood Diseases in The Research Institute.
Much of the cancer - killing effect of the oHSV injections was lost when the researchers tested the therapy in tumors of mice with
defective immune systems.
However, dogs that produce litters that are prone to long - term demodectic mange have
defective immune systems.
This discoloration is the result of excessive bilirubin in the bloodstream, which can be the result of either backed up liver circulation due to disease, or as the result of excessive accumulation of bilirubin due to the destruction of red blood cells caused by a disruption in red blood cell metabolism,
a defective immune system, or both.
Akitas can be born with
a defective immune system, which attacks their own skin (lupus), their digestive system (colitis), their thyroid (thyroiditis), or their spinal cord (degenerative myelopathy, which progresses to paralysis).
Autoimmune diseases, where an Akita Inu's
defective immune system «turns» on its own body and damages it, killed another 7 % of Akitas in the club survey.
Diseases caused by
a defective immune system are of particular concern among many purebred fanciers.
When
the defective immune system targets the skin, the result can be pemphigus, lupus, or vitiligo.
Adult dogs that have the disease usually have
defective immune systems.
(ref) But remember, just like us, there will always be a few outliers - dogs and cats with
defective immune systems - that react badly to vaccines.
There will always be the rare exception: The pet with
a defective immune system.
Very rarely, the puppy or dog has
a defective immune system and is incapable of seroconverting.
When
the defective immune system targets other organs, the resulting diseases include degenerative spinal myelopathy, megaesophagus, and myasthenia gravis.
Often the skin is the target of
the defective immune system.